U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Acadm acyl-CoA dehydrogenase medium chain [ Rattus norvegicus (Norway rat) ]

Gene ID: 24158, updated on 8-Dec-2022

Summary

Official Symbol
Acadmprovided by RGD
Official Full Name
acyl-CoA dehydrogenase medium chainprovided by RGD
Primary source
RGD:2012
See related
Ensembl:ENSRNOG00000009845 AllianceGenome:RGD:2012
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
MCAD
Summary
Enables several functions, including acyl-CoA dehydrogenase activity; identical protein binding activity; and nucleotide binding activity. Involved in several processes, including fatty acid catabolic process; response to copper ion; and response to glucocorticoid. Located in mitochondrial matrix and mitochondrial membrane. Biomarker of non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in medium chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADM (acyl-CoA dehydrogenase medium chain). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 2926.1), Muscle (RPKM 1889.4) and 6 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Acadm in Genome Data Viewer
Location:
2q45
Exon count:
12
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (242858865..242883036, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (260124418..260148589, complement)

Chromosome 2 - NC_051337.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 45A Neighboring gene Rab geranylgeranyltransferase subunit beta Neighboring gene small nucleolar RNA, C/D box 45C Neighboring gene small nucleolar RNA SNORA15 Neighboring gene solute carrier family 44, member 5 Neighboring gene LIM homeobox 8

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables acyl-CoA dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables acyl-CoA dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables acyl-CoA dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables fatty-acyl-CoA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables flavin adenine dinucleotide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables medium-chain-acyl-CoA dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables medium-chain-acyl-CoA dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
enables medium-chain-acyl-CoA dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cardiac muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in carnitine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within carnitine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in carnitine metabolic process, CoA-linked ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid beta-oxidation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in fatty acid beta-oxidation TAS
Traceable Author Statement
more info
PubMed 
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase ISO
Inferred from Sequence Orthology
more info
 
involved_in glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within liver development ISO
Inferred from Sequence Orthology
more info
 
involved_in medium-chain fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in medium-chain fatty acid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in medium-chain fatty acid catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in medium-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within organic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-embryonic development ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of gluconeogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to cold ISO
Inferred from Sequence Orthology
more info
 
involved_in response to copper ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to glucocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hormone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
medium-chain specific acyl-CoA dehydrogenase, mitochondrial
Names
Acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight-chain
acyl-CoA dehydrogenase, C-4 to C-12 straight chain
acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain
acyl-Coenzyme A dehydrogenase, medium chain
medium-chain acyl-CoA dehydrogenase
NP_058682.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016986.2NP_058682.2  medium-chain specific acyl-CoA dehydrogenase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_058682.2

    Status: VALIDATED

    Source sequence(s)
    BP502473, CK359511, J02791, JACYVU010000079
    UniProtKB/Swiss-Prot
    P08503
    UniProtKB/TrEMBL
    G3V796
    Related
    ENSRNOP00000013238.1, ENSRNOT00000013238.4
    Conserved Domains (2) summary
    cd01157
    Location:41418
    MCAD; Medium chain acyl-CoA dehydrogenase
    COG1960
    Location:39420
    CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051337.1 Reference mRatBN7.2 Primary Assembly

    Range
    242858865..242883036 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)