Acaa1a acetyl-CoA acyltransferase 1A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acaa1aprovided by RGD
Official Full Name: acetyl-CoA acyltransferase 1Aprovided by RGD
Primary source: RGD:67379
See related: Ensembl:ENSRNOG00000032908 AllianceGenome:RGD:67379
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Acaa; Acaa1; Pktaa
Summary: Enables acetyl-CoA C-acyltransferase activity; acetyl-CoA C-myristoyltransferase activity; and palmitoyl-CoA oxidase activity. Involved in several processes, including monocarboxylic acid metabolic process; response to nutrient; and response to steroid hormone. Located in peroxisome. Orthologous to human ACAA1 (acetyl-CoA acyltransferase 1). [provided by Alliance of Genome Resources, Jun 2025]
Expression: Biased expression in Liver (RPKM 689.3), Kidney (RPKM 474.6) and 9 other tissues See more
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Genomic context

Location:: 8q32

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (127956126..127966348)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (119079401..119088626)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (128027880..128036471)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D8Arb22 (e-PCR)
- UniSTS:240434

BI274607 (e-PCR)
- UniSTS:249146

D8Wox10 (e-PCR)
- UniSTS:118087

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acetate CoA-transferase activity	ISO Inferred from Sequence Orthology more info
enables acetyl-CoA C-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acetyl-CoA C-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetyl-CoA C-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetyl-CoA C-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acetyl-CoA C-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables acetyl-CoA C-myristoyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetyl-CoA C-myristoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity, transferring groups other than amino-acyl groups	IEA Inferred from Electronic Annotation more info
enables palmitoyl-CoA oxidase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables palmitoyl-CoA oxidase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in alpha-linolenic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in bile acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in bile acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid beta-oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid beta-oxidation	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid beta-oxidation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
involved_in fatty acid beta-oxidation using acyl-CoA oxidase	IEA Inferred from Electronic Annotation more info
involved_in fatty acid derivative biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phenylacetate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to nutrient	IDA Inferred from Direct Assay more info	PubMed
involved_in response to steroid hormone	IDA Inferred from Direct Assay more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in unsaturated fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in very long-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IEA Inferred from Electronic Annotation more info
is_active_in peroxisome	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 3-ketoacyl-CoA thiolase A, peroxisomal

Names: Acetyl-CoA acyltransferase 3-oxo acyl-CoA thiolase A peroxisomal; acetyl-CoA C-myristoyltransferase; acetyl-CoA acyltransferase 1; acetyl-CoA acyltransferase 3-oxo acyl-CoA thiolase A 1 peroxisomal; acetyl-CoA acyltransferase A; acetyl-CoA acyltransferase, 3-oxo acyl-CoA thiolase A; acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-Coenzyme A thiolase); acetyl-Coenzyme A acyltransferase 1A; beta-ketothiolase A; peroxisomal 3-oxoacyl-CoA thiolase A; thiolase A

NP_001382591.1

EC 2.3.1.155

EC 2.3.1.16

EC 2.3.1.9

NP_036621.2

EC 2.3.1.155

EC 2.3.1.16

EC 2.3.1.9

XP_038936714.1

EC 2.3.1.155

EC 2.3.1.16

EC 2.3.1.9

XP_063120956.1

EC 2.3.1.155

EC 2.3.1.16

EC 2.3.1.9

XP_063120957.1

EC 2.3.1.155

EC 2.3.1.16

EC 2.3.1.9

XP_063120958.1

EC 2.3.1.155

EC 2.3.1.16

EC 2.3.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395662.1 → NP_001382591.1 3-ketoacyl-CoA thiolase A, peroxisomal isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A8I6G309, F1LPD6

Related

ENSRNOP00000079249.1, ENSRNOT00000107742.2

Conserved Domains (1) summary

PLN02287
Location:9 → 343

PLN02287; 3-ketoacyl-CoA thiolase
NM_012489.3 → NP_036621.2 3-ketoacyl-CoA thiolase A, peroxisomal isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

P21775, Q5FVR9

UniProtKB/TrEMBL

A0A8I6AHC5, A6I3W1

Conserved Domains (1) summary

PLN02287
Location:9 → 430

PLN02287; 3-ketoacyl-CoA thiolase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

127956126..127966348

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063264886.1 → XP_063120956.1 3-ketoacyl-CoA thiolase A, peroxisomal isoform X1

UniProtKB/Swiss-Prot

P21775, Q5FVR9

UniProtKB/TrEMBL

A0A8I6AHC5, A6I3W1

Related

ENSRNOP00000092329.1, ENSRNOT00000103723.2
XM_039080786.2 → XP_038936714.1 3-ketoacyl-CoA thiolase A, peroxisomal isoform X1

UniProtKB/Swiss-Prot

P21775, Q5FVR9

UniProtKB/TrEMBL

A0A8I6AHC5, A6I3W1

Conserved Domains (1) summary

PLN02287
Location:9 → 430

PLN02287; 3-ketoacyl-CoA thiolase
XM_063264887.1 → XP_063120957.1 3-ketoacyl-CoA thiolase A, peroxisomal isoform X1

UniProtKB/Swiss-Prot

P21775, Q5FVR9

UniProtKB/TrEMBL

A0A8I6AHC5, A6I3W1
XM_063264888.1 → XP_063120958.1 3-ketoacyl-CoA thiolase A, peroxisomal isoform X1

UniProtKB/Swiss-Prot

P21775, Q5FVR9

UniProtKB/TrEMBL

A0A8I6AHC5, A6I3W1