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A2m alpha-2-macroglobulin [ Rattus norvegicus (Norway rat) ]

Gene ID: 24153, updated on 9-Dec-2018

Summary

Official Symbol
A2mprovided by RGD
Official Full Name
alpha-2-macroglobulinprovided by RGD
Primary source
RGD:2004
See related
Ensembl:ENSRNOG00000028896
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mam; A2m1; A2mb; A2maa; A2MAC1
Summary
plays a role in acute phase response; activated form induces a decrease in N-methyl-D-aspartate (NMDA) mediated calcium signaling [RGD, Feb 2006]
Expression
Biased expression in Liver (RPKM 371.9), Uterus (RPKM 135.2) and 3 other tissues See more

Genomic context

See A2m in Genome Data Viewer
Location:
4q42
Exon count:
36
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (154309426..154359138)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (221393233..221442945)

Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene similar to eukaryotic translation elongation factor 1 epsilon 1 Neighboring gene murinoglobulin 2 Neighboring gene alpha-1-inhibitor 3-like Neighboring gene voltage-dependent anion-selective channel protein 2-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC114358

Gene Ontology Provided by RGD

Function Evidence Code Pubs
brain-derived neurotrophic factor binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
growth factor binding ISO
Inferred from Sequence Orthology
more info
 
interleukin-1 binding ISO
Inferred from Sequence Orthology
more info
 
interleukin-8 binding ISO
Inferred from Sequence Orthology
more info
 
nerve growth factor binding IDA
Inferred from Direct Assay
more info
PubMed 
protease binding ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
serine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
tumor necrosis factor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acute inflammatory response to antigenic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
acute-phase response IEP
Inferred from Expression Pattern
more info
PubMed 
embryonic liver development IEP
Inferred from Expression Pattern
more info
PubMed 
luteinization IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of complement activation, lectin pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homotetramerization IDA
Inferred from Direct Assay
more info
PubMed 
response to carbon dioxide IEP
Inferred from Expression Pattern
more info
PubMed 
response to glucocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
response to prostaglandin E IEP
Inferred from Expression Pattern
more info
PubMed 
response to wounding TAS
Traceable Author Statement
more info
PubMed 
stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
alpha-2-macroglobulin
Names
alpha-2-M
alpha-2-macroglobulin-P

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012488.2NP_036620.2  alpha-2-macroglobulin precursor

    See identical proteins and their annotated locations for NP_036620.2

    Status: PROVISIONAL

    Source sequence(s)
    BC098922
    UniProtKB/Swiss-Prot
    P06238
    Related
    ENSRNOP00000019346.5, ENSRNOT00000019346.6
    Conserved Domains (6) summary
    cd02897
    Location:9561262
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:736826
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:132224
    A2M_N; MG2 domain
    pfam07677
    Location:13741461
    A2M_recep; A-macroglobulin receptor
    pfam07678
    Location:10081263
    A2M_comp; A-macroglobulin complement component
    pfam07703
    Location:464609
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

    Range
    154309426..154359138
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000072.1 Alternate Rn_Celera

    Range
    143730195..143781190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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