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Asip agouti signaling protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 24152, updated on 20-Apr-2019

Summary

Official Symbol
Asipprovided by RGD
Official Full Name
agouti signaling proteinprovided by RGD
Primary source
RGD:2003
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ASP
Summary
This gene is involved in hair pigmentation. In several strains (ACI, IS, LEA, LEC, NER, and WKAH) this gene encodes a functional protein while in others (BN, BUF, DON, F344, SD, SHR, TM, WKY, and WTC) it lacks a 19 nt indel and is non-protein coding. [provided by RefSeq, Apr 2015]
Orthologs

Genomic context

See Asip in Genome Data Viewer
Location:
3q41
Exon count:
4
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (150492010..150579870)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (156860395..156949277)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene RALY heterogeneous nuclear ribonucleoprotein Neighboring gene protein transport protein Sec61 subunit gamma-like Neighboring gene eukaryotic translation initiation factor 2 subunit beta Neighboring gene adenosylhomocysteinase Neighboring gene similar to 60S ribosomal protein L12

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
  • Melanogenesis, organism-specific biosystem (from KEGG)
    Melanogenesis, organism-specific biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
  • Melanogenesis, conserved biosystem (from KEGG)
    Melanogenesis, conserved biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
melanocortin receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
molecular_function ND
No biological Data available
more info
 
signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
type 3 melanocortin receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
type 4 melanocortin receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
adult feeding behavior ISO
Inferred from Sequence Orthology
more info
PubMed 
biological_process ND
No biological Data available
more info
 
generation of precursor metabolites and energy ISO
Inferred from Sequence Orthology
more info
PubMed 
genetic imprinting ISO
Inferred from Sequence Orthology
more info
PubMed 
hormone-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
melanin biosynthetic process ISO
Inferred from Sequence Orthology
more info
PubMed 
melanosome organization ISO
Inferred from Sequence Orthology
more info
PubMed 
melanosome transport ISO
Inferred from Sequence Orthology
more info
PubMed 
pigmentation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of melanin biosynthetic process ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of molecular function, epigenetic ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
agouti-signaling protein
Names
Agouti (coat color)
agouti switch protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052979.2NP_443211.1  agouti-signaling protein precursor

    See identical proteins and their annotated locations for NP_443211.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, coding) represents the protein-coding allele.
    Source sequence(s)
    AB045587
    UniProtKB/Swiss-Prot
    Q99JA2
    Conserved Domains (1) summary
    smart00792
    Location:6127
    Agouti; Agouti protein

RNA

  1. NR_131764.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, non-coding) represents the pseudogene allele.
    Source sequence(s)
    AABR07054373, AC123232

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    150492010..150579870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    142203571..142291520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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