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PRPF6 pre-mRNA processing factor 6 [ Homo sapiens (human) ]

Gene ID: 24148, updated on 23-Nov-2021

Summary

Official Symbol
PRPF6provided by HGNC
Official Full Name
pre-mRNA processing factor 6provided by HGNC
Primary source
HGNC:HGNC:15860
See related
Ensembl:ENSG00000101161 MIM:613979
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TOM; ANT1; Prp6; RP60; ANT-1; hPrp6; U5-102K; C20orf14; SNRNP102
Summary
The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 30.6), ovary (RPKM 27.5) and 25 other tissues See more
Orthologs
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Genomic context

See PRPF6 in Genome Data Viewer
Location:
20q13.33
Exon count:
21
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (63981132..64033100)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (62612485..62664453)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene UCKL1 antisense RNA 1 Neighboring gene zinc finger protein 512B Neighboring gene Sharpr-MPRA regulatory region 2003 Neighboring gene sterile alpha motif domain containing 10 Neighboring gene chromosome 20 open reading frame 204 Neighboring gene SOX18 promoter region Neighboring gene transcription elongation factor A2 Neighboring gene SRY-box transcription factor 18

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
GeneReviews: Not available
Retinitis pigmentosa 60 Compare labs

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae, PRPF6) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, pre-mRNA processing factor 6 homolog (PRPF6), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with PRPF6 is increased by RRE PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables androgen receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ribonucleoprotein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coactivator activity IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of U2-type precatalytic spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of U4/U6 x U5 tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of U4/U6 x U5 tri-snRNP complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of U5 snRNP IDA
Inferred from Direct Assay
more info
PubMed 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane HDA PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of spliceosomal complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
pre-mRNA-processing factor 6
Names
PRP6 homolog
PRP6 pre-mRNA processing factor 6 homolog
U5 snRNP-associated 102 kDa protein
U5-102 kDa protein
androgen receptor N-terminal domain transactivating protein-1
p102 U5 small nuclear ribonucleoprotein particle-binding protein
putative mitochondrial outer membrane protein import receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029719.1 RefSeqGene

    Range
    5055..57023
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_012469.4NP_036601.2  pre-mRNA-processing factor 6

    See identical proteins and their annotated locations for NP_036601.2

    Status: REVIEWED

    Source sequence(s)
    AF221842, BP366197
    Consensus CDS
    CCDS13550.1
    UniProtKB/Swiss-Prot
    O94906
    Related
    ENSP00000266079.4, ENST00000266079.5
    Conserved Domains (3) summary
    TIGR02917
    Location:290846
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:708738
    TPR; TPR repeat [structural motif]
    pfam06424
    Location:13169
    PRP1_N; PRP1 splicing factor, N-terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    63981132..64033100
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723769.3XP_006723832.1  pre-mRNA-processing factor 6 isoform X1

    Conserved Domains (3) summary
    sd00006
    Location:635665
    TPR; TPR repeat [structural motif]
    pfam06424
    Location:13169
    PRP1_N; PRP1 splicing factor, N-terminal
    cl26002
    Location:289773
    TPR_11; TPR repeat
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