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CLDN15 claudin 15 [ Homo sapiens (human) ]

Gene ID: 24146, updated on 11-Jun-2021

Summary

Official Symbol
CLDN15provided by HGNC
Official Full Name
claudin 15provided by HGNC
Primary source
HGNC:HGNC:2036
See related
Ensembl:ENSG00000106404 MIM:615778
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010]
Expression
Biased expression in duodenum (RPKM 65.8), small intestine (RPKM 50.2) and 8 other tissues See more
Orthologs
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Genomic context

See CLDN15 in Genome Data Viewer
Location:
7q22.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (101232094..101238820, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100875375..100882101, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 Neighboring gene zinc finger HIT-type containing 1 Neighboring gene fission, mitochondrial 1 Neighboring gene RNA, U6 small nuclear 1104, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Impact of ancestry and common genetic variants on QT interval in African Americans.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ42715, MGC19536

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in bicellular tight junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in bicellular tight junction ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in lateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001185080.2NP_001172009.1  claudin-15

    See identical proteins and their annotated locations for NP_001172009.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK056103, DB158141
    Consensus CDS
    CCDS5717.1
    UniProtKB/Swiss-Prot
    P56746
    Related
    ENSP00000385300.1, ENST00000401528.5
    Conserved Domains (1) summary
    cl21598
    Location:3177
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
  2. NM_014343.3NP_055158.1  claudin-15

    See identical proteins and their annotated locations for NP_055158.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a shorter and alternate 5' UTR, as compared to variant 1.
    Source sequence(s)
    AJ245738, AK056103
    Consensus CDS
    CCDS5717.1
    UniProtKB/Swiss-Prot
    P56746
    Related
    ENSP00000308870.5, ENST00000308344.10
    Conserved Domains (1) summary
    cl21598
    Location:3177
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    101232094..101238820 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_138429.1: Suppressed sequence

    Description
    NM_138429.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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