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CLDN15 claudin 15 [ Homo sapiens (human) ]

Gene ID: 24146, updated on 4-May-2020

Summary

Official Symbol
CLDN15provided by HGNC
Official Full Name
claudin 15provided by HGNC
Primary source
HGNC:HGNC:2036
See related
Ensembl:ENSG00000106404 MIM:615778
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010]
Expression
Biased expression in duodenum (RPKM 65.8), small intestine (RPKM 50.2) and 8 other tissues See more
Orthologs

Genomic context

See CLDN15 in Genome Data Viewer
Location:
7q22.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (101232092..101238820, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100875373..100882101, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 Neighboring gene zinc finger HIT-type containing 1 Neighboring gene fission, mitochondrial 1 Neighboring gene RNA, U6 small nuclear 1104, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ42715, MGC19536

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
bicellular tight junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
 
cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bicellular tight junction ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001185080.1NP_001172009.1  claudin-15

    See identical proteins and their annotated locations for NP_001172009.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA514265, AK056103, DB158141
    Consensus CDS
    CCDS5717.1
    UniProtKB/Swiss-Prot
    P56746
    Related
    ENSP00000385300.1, ENST00000401528.5
    Conserved Domains (1) summary
    cl21598
    Location:3177
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
  2. NM_014343.3NP_055158.1  claudin-15

    See identical proteins and their annotated locations for NP_055158.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a shorter and alternate 5' UTR, as compared to variant 1.
    Source sequence(s)
    AJ245738, AK056103
    Consensus CDS
    CCDS5717.1
    UniProtKB/Swiss-Prot
    P56746
    Related
    ENSP00000308870.5, ENST00000308344.9
    Conserved Domains (1) summary
    cl21598
    Location:3177
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    101232092..101238820 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_138429.1: Suppressed sequence

    Description
    NM_138429.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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