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Cers6 ceramide synthase 6 [ Mus musculus (house mouse) ]

Gene ID: 241447, updated on 5-Mar-2024

Summary

Official Symbol
Cers6provided by MGI
Official Full Name
ceramide synthase 6provided by MGI
Primary source
MGI:MGI:2442564
See related
Ensembl:ENSMUSG00000027035 AllianceGenome:MGI:2442564
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
T1L; Lass6; 4732462C07Rik
Summary
Enables sphingosine N-acyltransferase activity. Acts upstream of or within ceramide biosynthetic process. Located in endoplasmic reticulum. Is expressed in blastocyst; early embryo; genitourinary system; and limb mesenchyme. Orthologous to human CERS6 (ceramide synthase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 3.5), large intestine adult (RPKM 3.5) and 27 other tissues See more
Orthologs
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Genomic context

See Cers6 in Genome Data Viewer
Location:
2 C2; 2 39.53 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (68691489..68944628)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (68861145..69114284)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 36231 Neighboring gene predicted gene, 36174 Neighboring gene predicted gene 13612 Neighboring gene STARR-seq mESC enhancer starr_04715 Neighboring gene STARR-seq mESC enhancer starr_04717 Neighboring gene STARR-seq mESC enhancer starr_04719 Neighboring gene predicted gene, 52515 Neighboring gene STARR-seq mESC enhancer starr_04722 Neighboring gene STARR-seq mESC enhancer starr_04727 Neighboring gene predicted gene, 39840 Neighboring gene nitric oxide synthase trafficker Neighboring gene SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sphingosine N-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sphingosine N-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sphingosine N-acyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables sphingosine N-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ceramide synthase 6
Names
LAG1 homolog, ceramide synthase 6
LAG1 longevity assurance homolog 6
longevity assurance homolog 6
sphingoid base N-palmitoyltransferase CERS6
NP_001334090.1
NP_766444.1
XP_017173563.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347161.2NP_001334090.1  ceramide synthase 6 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AL929137, AL929221
    Consensus CDS
    CCDS84532.1
    UniProtKB/TrEMBL
    H3BL08
    Related
    ENSMUSP00000135604.2, ENSMUST00000176018.2
    Conserved Domains (2) summary
    cd00086
    Location:76127
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam03798
    Location:131324
    TRAM_LAG1_CLN8; TLC domain
  2. NM_172856.5NP_766444.1  ceramide synthase 6 isoform 2

    See identical proteins and their annotated locations for NP_766444.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL929137, AL929221
    Consensus CDS
    CCDS16086.1
    UniProtKB/Swiss-Prot
    Q3U817, Q8BV12, Q8C172
    Related
    ENSMUSP00000028426.3, ENSMUST00000028426.9
    Conserved Domains (2) summary
    cd00086
    Location:76127
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam03798
    Location:131324
    TRAM_LAG1_CLN8; TLC domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    68691489..68944628
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318074.1XP_017173563.1  ceramide synthase 6 isoform X1

    Conserved Domains (1) summary
    pfam03798
    Location:6193
    TRAM_LAG1_CLN8; TLC domain

RNA

  1. XR_374464.4 RNA Sequence