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LAMP5 lysosomal associated membrane protein family member 5 [ Homo sapiens (human) ]

Gene ID: 24141, updated on 17-Jun-2019

Summary

Official Symbol
LAMP5provided by HGNC
Official Full Name
lysosomal associated membrane protein family member 5provided by HGNC
Primary source
HGNC:HGNC:16097
See related
Ensembl:ENSG00000125869 MIM:614641
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LAMP-5; UNC-46; BADLAMP; BAD-LAMP; C20orf103
Expression
Biased expression in brain (RPKM 17.1), ovary (RPKM 10.7) and 6 other tissues See more
Orthologs

Genomic context

See LAMP5 in Genome Data Viewer
Location:
20p12.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (9514358..9530524)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (9495005..9511171)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372522 Neighboring gene Sharpr-MPRA regulatory region 7247 Neighboring gene phospholipase C beta 4 Neighboring gene LAMP5 antisense RNA 1 Neighboring gene uncharacterized LOC105372523 Neighboring gene uncharacterized LOC101929348 Neighboring gene p21 (RAC1) activated kinase 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
establishment of protein localization to organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
dendrite membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
early endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum-Golgi intermediate compartment membrane IDA
Inferred from Direct Assay
more info
PubMed 
endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
growth cone membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
recycling endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
lysosome-associated membrane glycoprotein 5
Names
LAMP family protein C20orf103
brain and dendritic cell-associated LAMP
brain-associated LAMP-like protein
lysosome-associated membrane protein 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199897.1NP_001186826.1  lysosome-associated membrane glycoprotein 5 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001186826.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1, and encodes a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AK316114, AL031652, BC050727
    Consensus CDS
    CCDS56177.1
    UniProtKB/Swiss-Prot
    Q9UJQ1
    Related
    ENSP00000406360.1, ENST00000427562.6
    Conserved Domains (1) summary
    pfam01299
    Location:40185
    Lamp; Lysosome-associated membrane glycoprotein (Lamp)
  2. NM_012261.4NP_036393.1  lysosome-associated membrane glycoprotein 5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_036393.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL031652, BC050727
    Consensus CDS
    CCDS13106.1
    UniProtKB/Swiss-Prot
    Q9UJQ1
    Related
    ENSP00000246070.2, ENST00000246070.3
    Conserved Domains (1) summary
    pfam01299
    Location:40229
    Lamp; Lysosome-associated membrane glycoprotein (Lamp)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    9514358..9530524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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