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IFIT5 interferon induced protein with tetratricopeptide repeats 5 [ Homo sapiens (human) ]

Gene ID: 24138, updated on 6-Sep-2022

Summary

Official Symbol
IFIT5provided by HGNC
Official Full Name
interferon induced protein with tetratricopeptide repeats 5provided by HGNC
Primary source
HGNC:HGNC:13328
See related
Ensembl:ENSG00000152778 MIM:616135; AllianceGenome:HGNC:13328
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P58; RI58; ISG58
Summary
Enables nucleic acid binding activity. Involved in defense response to virus; negative regulation of viral genome replication; and positive regulation of I-kappaB kinase/NF-kappaB signaling. Located in actin cytoskeleton; apical part of cell; and ruffle membrane. Colocalizes with IkappaB kinase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen (RPKM 7.8), lung (RPKM 7.7) and 25 other tissues See more
Orthologs
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Genomic context

See IFIT5 in Genome Data Viewer
Location:
10q23.31
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (89414568..89420997)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (90298411..90304831)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (91174325..91180754)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene interferon induced protein with tetratricopeptide repeats 1B Neighboring gene uncharacterized LOC107984251 Neighboring gene interferon induced protein with tetratricopeptide repeats 1 Neighboring gene solute carrier family 16 member 12 Neighboring gene SLC16A12 antisense RNA 1 Neighboring gene pantothenate kinase 1 Neighboring gene microRNA 107

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ53857, FLJ92678

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA cap binding IDA
Inferred from Direct Assay
more info
PubMed 
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables poly(U) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables single-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables tRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
located_in ruffle membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
interferon-induced protein with tetratricopeptide repeats 5
Names
IFIT-5
interferon-induced 58 kDa protein
retinoic acid- and interferon-inducible 58 kDa protein
retinoic acid- and interferon-inducible protein (58kD)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012420.3NP_036552.1  interferon-induced protein with tetratricopeptide repeats 5

    See identical proteins and their annotated locations for NP_036552.1

    Status: VALIDATED

    Source sequence(s)
    AL353146, DC392439
    Consensus CDS
    CCDS7403.1
    UniProtKB/Swiss-Prot
    Q13325, Q6IAX3
    Related
    ENSP00000360860.4, ENST00000371795.5
    Conserved Domains (3) summary
    TIGR02917
    Location:157470
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:249277
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:49116
    TPR_12; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    89414568..89420997
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    90298411..90304831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)