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Zeb2 zinc finger E-box binding homeobox 2 [ Mus musculus (house mouse) ]

Gene ID: 24136, updated on 8-Feb-2024

Summary

Official Symbol
Zeb2provided by MGI
Official Full Name
zinc finger E-box binding homeobox 2provided by MGI
Primary source
MGI:MGI:1344407
See related
Ensembl:ENSMUSG00000026872 AllianceGenome:MGI:1344407
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SIP1; Zfx1b; Zfhx1b; Zfxh1b; 9130203F04Rik; D130016B08Rik
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and R-SMAD binding activity. Involved in several processes, including melanocyte migration; positive regulation of cell differentiation; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including nervous system development; neural crest cell migration; and positive regulation of signal transduction. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study Mowat-Wilson syndrome and T-cell adult acute lymphocytic leukemia. Human ortholog(s) of this gene implicated in Hirschsprung's disease and Mowat-Wilson syndrome. Orthologous to human ZEB2 (zinc finger E-box binding homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 11.4), CNS E18 (RPKM 9.1) and 23 other tissues See more
Orthologs
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Genomic context

See Zeb2 in Genome Data Viewer
Location:
2 B; 2 27.31 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (44873523..45007378, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (44983512..45117442, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene glycosyltransferase-like domain containing 1 Neighboring gene predicted gene, 39807 Neighboring gene STARR-seq mESC enhancer starr_04399 Neighboring gene centromere protein C1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:44816144-44816341 Neighboring gene STARR-seq mESC enhancer starr_04400 Neighboring gene microRNA 5129 Neighboring gene STARR-seq mESC enhancer starr_04403 Neighboring gene zinc finger E-box binding homeobox 2, opposite strand Neighboring gene STARR-positive B cell enhancer mm9_chr2:45049987-45050287 Neighboring gene STARR-seq mESC enhancer starr_04405 Neighboring gene STARR-seq mESC enhancer starr_04406 Neighboring gene VISTA enhancer mm1737 Neighboring gene STARR-seq mESC enhancer starr_04408 Neighboring gene viral integration site 1 Neighboring gene STARR-seq mESC enhancer starr_04409 Neighboring gene STARR-seq mESC enhancer starr_04410 Neighboring gene predicted gene 13479 Neighboring gene predicted gene, 30728

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0569

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in anatomical structure development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in astrocyte activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell proliferation in forebrain IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within central nervous system development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within collateral sprouting IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within corpus callosum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within corticospinal tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in developmental pigmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in fibroblast activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hippocampus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mammillary axonal complex development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in melanocyte migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of fibroblast migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neural crest cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of JUN kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lens fiber cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of melanin biosynthetic process IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of melanocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of myofibroblast contraction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in pyroptosis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of blood-brain barrier permeability ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of melanosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of myofibroblast cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to oxygen-glucose deprivation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within somitogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
zinc finger E-box-binding homeobox 2
Names
smad-interacting protein 1
zinc finger homeobox protein 1b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289521.2NP_001276450.1  zinc finger E-box-binding homeobox 2

    See identical proteins and their annotated locations for NP_001276450.1

    Status: VALIDATED

    Source sequence(s)
    AL929120, AL935127
    Consensus CDS
    CCDS16020.1
    UniProtKB/Swiss-Prot
    Q6P9M5, Q9R0G7
    UniProtKB/TrEMBL
    H9H9S3, Q3URW5
    Related
    ENSMUSP00000134747.2, ENSMUST00000177302.8
    Conserved Domains (4) summary
    cd00086
    Location:653695
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00017
    Location:10011021
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:282304
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:296319
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001355288.2NP_001342217.1  zinc finger E-box-binding homeobox 2

    Status: VALIDATED

    Source sequence(s)
    AL929120, AL935127
    Consensus CDS
    CCDS16020.1
    UniProtKB/Swiss-Prot
    Q6P9M5, Q9R0G7
    UniProtKB/TrEMBL
    H9H9S3, Q3URW5
    Related
    ENSMUSP00000134849.2, ENSMUST00000176438.9
    Conserved Domains (4) summary
    cd00086
    Location:653695
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00017
    Location:10011021
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:282304
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:296319
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001355289.2NP_001342218.1  zinc finger E-box-binding homeobox 2

    Status: VALIDATED

    Source sequence(s)
    AL929120, AL935127
    Consensus CDS
    CCDS16020.1
    UniProtKB/Swiss-Prot
    Q6P9M5, Q9R0G7
    UniProtKB/TrEMBL
    H9H9S3, Q3URW5
    Conserved Domains (4) summary
    cd00086
    Location:653695
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00017
    Location:10011021
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:282304
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:296319
    zf-H2C2_2; Zinc-finger double domain
  4. NM_001355290.2NP_001342219.1  zinc finger E-box-binding homeobox 2

    Status: VALIDATED

    Source sequence(s)
    AL929120, AL935127
    Consensus CDS
    CCDS16020.1
    UniProtKB/Swiss-Prot
    Q6P9M5, Q9R0G7
    UniProtKB/TrEMBL
    H9H9S3, Q3URW5
    Conserved Domains (4) summary
    cd00086
    Location:653695
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00017
    Location:10011021
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:282304
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:296319
    zf-H2C2_2; Zinc-finger double domain
  5. NM_001355291.2NP_001342220.1  zinc finger E-box-binding homeobox 2

    Status: VALIDATED

    Source sequence(s)
    AL929120, AL935127
    Consensus CDS
    CCDS16020.1
    UniProtKB/Swiss-Prot
    Q6P9M5, Q9R0G7
    UniProtKB/TrEMBL
    H9H9S3, Q3URW5
    Related
    ENSMUSP00000028229.8, ENSMUST00000028229.13
    Conserved Domains (4) summary
    cd00086
    Location:653695
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00017
    Location:10011021
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:282304
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:296319
    zf-H2C2_2; Zinc-finger double domain
  6. NM_015753.5NP_056568.2  zinc finger E-box-binding homeobox 2

    See identical proteins and their annotated locations for NP_056568.2

    Status: VALIDATED

    Source sequence(s)
    AL929120, AL935127
    Consensus CDS
    CCDS16020.1
    UniProtKB/Swiss-Prot
    Q6P9M5, Q9R0G7
    UniProtKB/TrEMBL
    H9H9S3, Q3URW5
    Related
    ENSMUSP00000069685.5, ENSMUST00000068415.11
    Conserved Domains (4) summary
    cd00086
    Location:653695
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00017
    Location:10011021
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:282304
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:296319
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_149354.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL935127
    Related
    ENSMUST00000153561.6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    44873523..45007378 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)