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Ralgps1 Ral GEF with PH domain and SH3 binding motif 1 [ Mus musculus (house mouse) ]

Gene ID: 241308, updated on 26-Sep-2022

Summary

Official Symbol
Ralgps1provided by MGI
Official Full Name
Ral GEF with PH domain and SH3 binding motif 1provided by MGI
Primary source
MGI:MGI:1922008
See related
Ensembl:ENSMUSG00000038831 AllianceGenome:MGI:1922008
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RALGEF2; RALGPS1A; RalGEF 2; mKIAA0351; 5830418G11Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of Ral protein signal transduction. Predicted to be located in cytoplasm and plasma membrane. Orthologous to human RALGPS1 (Ral GEF with PH domain and SH3 binding motif 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 23.6), whole brain E14.5 (RPKM 21.8) and 23 other tissues See more
Orthologs
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Genomic context

See Ralgps1 in Genome Data Viewer
Location:
2; 2 B
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (33023431..33261569, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (33133419..33371499, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene solute carrier family 2, (facilitated glucose transporter), member 8 Neighboring gene GTPase activating RANGAP domain-like 3 Neighboring gene predicted gene 13528 Neighboring gene predicted gene, 23546 Neighboring gene angiopoietin-like 2 Neighboring gene zinc finger and BTB domain containing 34 Neighboring gene predicted gene 13536 Neighboring gene zinc finger and BTB domain containing 43

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of Ral protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ras-specific guanine nucleotide-releasing factor RalGPS1
Names
Ral guanine nucleotide exchange factor RalGPS1A
ral GEF with PH domain and SH3-binding motif 1
ral guanine nucleotide exchange factor 2
ralA exchange factor RalGPS1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290570.1NP_001277499.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, and also lacks two exons and uses an alternate splice site that result in the loss of an in-frame segment in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AK129123, BC072656, CJ112478
    Consensus CDS
    CCDS71031.1
    UniProtKB/Swiss-Prot
    A2AR50
    UniProtKB/TrEMBL
    A0A8C6MVC8
    Related
    ENSMUSP00000048451.7, ENSMUST00000042615.13
    Conserved Domains (3) summary
    smart00147
    Location:38271
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:373488
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:372483
    PH; PH domain
  2. NM_001290572.1NP_001277501.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two exons that result in the loss of an in-frame segment in the 3' coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AK017939, BC072656, CJ112478
    Consensus CDS
    CCDS79779.1
    UniProtKB/Swiss-Prot
    A2AR50
    UniProtKB/TrEMBL
    A0A6P7QTB8, A0A8C6H4E4
    Related
    ENSMUSP00000118363.3, ENSMUST00000131298.7
    Conserved Domains (2) summary
    smart00147
    Location:46288
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:391506
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
  3. NM_175211.5NP_780420.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform a

    See identical proteins and their annotated locations for NP_780420.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK076767, BC072656, CJ112478
    Consensus CDS
    CCDS15939.1
    UniProtKB/Swiss-Prot
    A2AR50, Q8C1I2
    UniProtKB/TrEMBL
    A0A6P5R1F5, A0A8C6H355
    Related
    ENSMUSP00000088563.3, ENSMUST00000091039.5
    Conserved Domains (2) summary
    smart00147
    Location:46288
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:461576
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    33023431..33261569 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498037.4XP_006498100.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X7

    UniProtKB/TrEMBL
    A0A6P7QZ00
    Conserved Domains (2) summary
    smart00147
    Location:46288
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:390505
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
  2. XM_006498033.4XP_006498096.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X2

    Conserved Domains (2) summary
    smart00147
    Location:46288
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:460575
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
  3. XM_030251025.2XP_030106885.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X9

    Conserved Domains (2) summary
    smart00147
    Location:21252
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:354469
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
  4. XM_006498035.4XP_006498098.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X4

    Conserved Domains (2) summary
    smart00147
    Location:21252
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:425540
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
  5. XM_006498034.5XP_006498097.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X3

    Conserved Domains (2) summary
    smart00147
    Location:38271
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:444559
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
  6. XM_030251023.2XP_030106883.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X8

    Conserved Domains (2) summary
    smart00147
    Location:38271
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:374489
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
  7. XM_036161819.1XP_036017712.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X11

    Conserved Domains (2) summary
    cd13310
    Location:329444
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    cl02485
    Location:46227
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
  8. XM_036161817.1XP_036017710.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X10

    Conserved Domains (2) summary
    cd13310
    Location:330445
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    cl02485
    Location:46227
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
  9. XM_036161812.1XP_036017705.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X5

    Conserved Domains (2) summary
    cd13310
    Location:400515
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    cl02485
    Location:46227
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
  10. XM_030251028.1XP_030106888.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X13

    Conserved Domains (2) summary
    cd13310
    Location:250365
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    cl02485
    Location:1147
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
  11. XM_030251026.2XP_030106886.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X12

    Conserved Domains (2) summary
    cd13310
    Location:320435
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    cl02485
    Location:1147
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
  12. XM_030251022.2XP_030106882.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X6

    UniProtKB/TrEMBL
    A0A6P7QTB8, A0A8C6H4E4
    Conserved Domains (2) summary
    smart00147
    Location:46288
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:391506
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
  13. XM_006498032.4XP_006498095.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X1

    See identical proteins and their annotated locations for XP_006498095.1

    UniProtKB/Swiss-Prot
    A2AR50, Q8C1I2
    UniProtKB/TrEMBL
    A0A6P5R1F5, A0A8C6H355
    Conserved Domains (2) summary
    smart00147
    Location:46288
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:461576
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
  14. XM_030251011.1XP_030106871.1  ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X1

    UniProtKB/Swiss-Prot
    Q8C1I2
    UniProtKB/TrEMBL
    A0A6P5R1F5, A0A8C6H355
    Conserved Domains (2) summary
    smart00147
    Location:46288
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:461576
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

RNA

  1. XR_004940327.1 RNA Sequence

  2. XR_003952801.2 RNA Sequence

  3. XR_374090.5 RNA Sequence

  4. XR_374091.4 RNA Sequence

  5. XR_374089.5 RNA Sequence

  6. XR_003952804.2 RNA Sequence

  7. XR_374092.5 RNA Sequence

  8. XR_003952802.2 RNA Sequence