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Wif1 Wnt inhibitory factor 1 [ Mus musculus (house mouse) ]

Gene ID: 24117, updated on 8-Feb-2024

Summary

Official Symbol
Wif1provided by MGI
Official Full Name
Wnt inhibitory factor 1provided by MGI
Primary source
MGI:MGI:1344332
See related
Ensembl:ENSMUSG00000020218 AllianceGenome:MGI:1344332
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
WIF-1
Summary
Predicted to enable Wnt-protein binding activity and signaling receptor binding activity. Acts upstream of or within positive regulation of fat cell differentiation. Predicted to be active in cell surface and extracellular region. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and urinary bladder cancer. Orthologous to human WIF1 (WNT inhibitory factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in limb E14.5 (RPKM 17.6), heart adult (RPKM 3.0) and 6 other tissues See more
Orthologs
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Genomic context

See Wif1 in Genome Data Viewer
Location:
10 D2; 10 68.98 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (120869909..120936547)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (121034004..121100642)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene LEM domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E10649 Neighboring gene predicted gene, 35235 Neighboring gene STARR-seq mESC enhancer starr_28078 Neighboring gene STARR-seq mESC enhancer starr_28079 Neighboring gene predicted gene, 40784 Neighboring gene STARR-seq mESC enhancer starr_28080 Neighboring gene STARR-seq mESC enhancer starr_28081 Neighboring gene predicted gene 10741 Neighboring gene predicted gene, 51756

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Wnt-protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables activin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nodal binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in anterior/posterior pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in blood vessel development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in determination of left/right symmetry IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in heart development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in nodal signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011915.2NP_036045.1  wnt inhibitory factor 1 precursor

    See identical proteins and their annotated locations for NP_036045.1

    Status: VALIDATED

    Source sequence(s)
    AK077698, AK142443
    Consensus CDS
    CCDS24209.1
    UniProtKB/Swiss-Prot
    Q9WUA1
    UniProtKB/TrEMBL
    H3BKQ8, Q3TYU1
    Related
    ENSMUSP00000020439.5, ENSMUST00000020439.11
    Conserved Domains (1) summary
    smart00469
    Location:35179
    WIF; Wnt-inhibitory factor-1 like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    120869909..120936547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)