U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Prkag3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit [ Mus musculus (house mouse) ]

Gene ID: 241113, updated on 27-Nov-2024

Summary

Official Symbol
Prkag3provided by MGI
Official Full Name
protein kinase, AMP-activated, gamma 3 non-catalytic subunitprovided by MGI
Primary source
MGI:MGI:1891343
See related
Ensembl:ENSMUSG00000006542 AllianceGenome:MGI:1891343
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Amkg3; Ampkg3; AMPKg3L; AMPKg3S
Summary
Contributes to AMP-activated protein kinase activity. Acts upstream of or within negative regulation of glycogen biosynthetic process; regulation of glycolytic process; and response to muscle activity involved in regulation of muscle adaptation. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of nucleotide-activated protein kinase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including heart and pericardium and nerve. Orthologous to human PRKAG3 (protein kinase AMP-activated non-catalytic subunit gamma 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in mammary gland adult (RPKM 4.6), lung adult (RPKM 3.6) and 8 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Prkag3 in Genome Data Viewer
Location:
1 C4; 1 38.54 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (74778062..74788623, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (74738922..74749471, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01341 Neighboring gene tubulin tyrosine ligase-like family, member 4 Neighboring gene cytochrome P450, family 27, subfamily a, polypeptide 1 Neighboring gene wingless-type MMTV integration site family, member 6 Neighboring gene STARR-seq mESC enhancer starr_01342 Neighboring gene predicted gene 29539 Neighboring gene STARR-seq mESC enhancer starr_01343 Neighboring gene predicted gene, 32099 Neighboring gene wingless-type MMTV integration site family, member 10A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables AMP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to AMP-activated protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
contributes_to AMP-activated protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
part_of nucleotide-activated protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of nucleotide-activated protein kinase complex ISO
Inferred from Sequence Orthology
more info
 
part_of nucleotide-activated protein kinase complex ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
5'-AMP-activated protein kinase subunit gamma-3
Names
AMP-activated protein kinase gamma subunit
AMPK gamma3
AMPK subunit gamma-3
protein kinase, AMP-activated, gamma 3 non-catatlytic subunit

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153744.4NP_714966.1  5'-AMP-activated protein kinase subunit gamma-3

    See identical proteins and their annotated locations for NP_714966.1

    Status: VALIDATED

    Source sequence(s)
    AC152409
    Consensus CDS
    CCDS15055.1
    UniProtKB/Swiss-Prot
    Q0VG42, Q80WK8, Q8BGM7, Q8CJ41
    Related
    ENSMUSP00000125344.2, ENSMUST00000160732.8
    Conserved Domains (2) summary
    cd04618
    Location:192329
    CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
    cd04641
    Location:355478
    CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    74778062..74788623 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495988.5XP_006496051.1  5'-AMP-activated protein kinase subunit gamma-3 isoform X1

    See identical proteins and their annotated locations for XP_006496051.1

    UniProtKB/Swiss-Prot
    Q0VG42, Q80WK8, Q8BGM7, Q8CJ41
    Conserved Domains (2) summary
    cd04618
    Location:192329
    CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
    cd04641
    Location:355478
    CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
  2. XM_006495989.5XP_006496052.1  5'-AMP-activated protein kinase subunit gamma-3 isoform X1

    See identical proteins and their annotated locations for XP_006496052.1

    UniProtKB/Swiss-Prot
    Q0VG42, Q80WK8, Q8BGM7, Q8CJ41
    Conserved Domains (2) summary
    cd04618
    Location:192329
    CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
    cd04641
    Location:355478
    CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_153745.3: Suppressed sequence

    Description
    NM_153745.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.