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Usp18 ubiquitin specific peptidase 18 [ Mus musculus (house mouse) ]

Gene ID: 24110, updated on 26-Jun-2024

Summary

Official Symbol
Usp18provided by MGI
Official Full Name
ubiquitin specific peptidase 18provided by MGI
Primary source
MGI:MGI:1344364
See related
Ensembl:ENSMUSG00000030107 AllianceGenome:MGI:1344364
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UBP43; Ubp15; 1110058H21Rik
Summary
Enables ISG15-specific protease activity. Acts upstream of or within response to bacterium and response to stilbenoid. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in cytosol and nucleus. Is expressed in axial skeleton; lung; and mandible. Orthologous to several human genes including USP18 (ubiquitin specific peptidase 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E18 (RPKM 13.2), thymus adult (RPKM 10.2) and 21 other tissues See more
Orthologs
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Genomic context

See Usp18 in Genome Data Viewer
Location:
6 F1; 6 57.17 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (121222865..121247876)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (121245906..121270917)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38651 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:121167996-121168280 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:121176131-121176438 Neighboring gene tubulin, alpha 8 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:121193284-121193537 Neighboring gene STARR-positive B cell enhancer ABC_E4859 Neighboring gene predicted gene, 44148 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:121222283-121222466 Neighboring gene solute carrier family 6 (neurotransmitter transporter, GABA), member 13 Neighboring gene STARR-positive B cell enhancer ABC_E6482 Neighboring gene solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ISG15-specific peptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ISG15-specific peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to stilbenoid IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ubl carboxyl-terminal hydrolase 18
Names
43 kDa ISG15-specific protease
ISG15-specific-processing protease
ubiquitin specific protease 15
ubiquitin specific protease 18
ubl thioesterase 18
ubl thiolesterase 18
NP_036039.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011909.2NP_036039.2  ubl carboxyl-terminal hydrolase 18

    See identical proteins and their annotated locations for NP_036039.2

    Status: VALIDATED

    Source sequence(s)
    AA286391, AK151260, AK153312
    Consensus CDS
    CCDS20489.1
    UniProtKB/Swiss-Prot
    Q3U7P3, Q9WTV6
    UniProtKB/TrEMBL
    B2RRS6, Q3UE35, Q4FK24
    Related
    ENSMUSP00000032198.10, ENSMUST00000032198.11
    Conserved Domains (2) summary
    cd02257
    Location:53363
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:51363
    UCH; Ubiquitin carboxyl-terminal hydrolase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    121222865..121247876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)