Dnah14 dynein, axonemal, heavy chain 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dnah14provided by MGI
Official Full Name: dynein, axonemal, heavy chain 14provided by MGI
Primary source: MGI:MGI:2444525
See related: Ensembl:ENSMUSG00000047369 AllianceGenome:MGI:2444525
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm980; Dnahc14; Gm18554; A230079K17Rik
Summary: Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in microtubule-based movement. Predicted to be part of dynein complex. Orthologous to human DNAH14 (dynein axonemal heavy chain 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 3.8) and cortex adult (RPKM 0.1) See more
Orthologs: human all
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Genomic context

Location:: 1; 1 H4- H5

Exon count:: 87

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (181404158..181642306)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (181576593..181814932)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D1Mit525 (e-PCR), detects polymorphism
- UniSTS:128891

21.MMHAP34FRG9.seq (e-PCR)
- UniSTS:123519

Homology

Homologs of the Dnah14 gene: The Dnah14 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, and frog.
Orthologs from Annotation Pipeline: 243 organisms have orthologs with human gene Dnah14
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables minus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
part_of dynein complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: dynein heavy chain 14, axonemal

Names: dynein, axonemal, heavy chain 14 pseudogene

NP_001363968.1

EC 3.6.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001377039.1 → NP_001363968.1 dynein heavy chain 14, axonemal

Status: VALIDATED

Source sequence(s)

AC113509, AC120366, AC165229

Related

ENSMUSP00000158787.3, ENSMUST00000238412.3

Conserved Domains (6) summary

COG5245
Location:1202 → 4193

DYN1; Dynein, heavy chain [Cytoskeleton]

pfam08393
Location:973 → 1378

DHC_N2; Dynein heavy chain, N-terminal region 2

pfam12774
Location:1511 → 1845

AAA_6; Hydrolytic ATP binding site of dynein motor region D1

pfam12781
Location:3348 → 3563

AAA_9; ATP-binding dynein motor region D5

pfam18199
Location:4202 → 4595

Dynein_C; Dynein heavy chain C-terminal domain

pfam13767
Location:328 → 391

DUF4168; Domain of unknown function (DUF4168)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

181404158..181642306

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NG_018673.1: Suppressed sequence

Description

NG_018673.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
NM_172846.2: Suppressed sequence

Description

NM_172846.2: This RefSeq was temporarily suppressed because the CDS was partial.