Pik3c2b phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pik3c2bprovided by MGI
Official Full Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 betaprovided by MGI
Primary source: MGI:MGI:2685045
See related: Ensembl:ENSMUSG00000026447 AllianceGenome:MGI:2685045
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm199; PI3KC2beta; PI3K-C2beta; C330011J12Rik
Summary: Enables lipid kinase activity. Acts upstream of or within several processes, including autophagosome organization; phosphatidylinositol-3-phosphate biosynthetic process; and protein kinase B signaling. Located in endocytic vesicle. Is expressed in eye; limb; nervous system; and skeleton. Orthologous to human PIK3C2B (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in colon adult (RPKM 14.0), spleen adult (RPKM 10.9) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 57.75 cM

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (132973410..133036429)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (133045672..133108691)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PI3K-C2beta limits mTORC1 signaling and angiogenic growth.
Title: PI3K-C2β limits mTORC1 signaling and angiogenic growth.
[PI3KC2beta: A promising therapeutic target in myotubular myopathy].
Title: [PI3KC2β: A promising therapeutic target in myotubular myopathy].
Inactivating the lipid kinase activity of PI3KC2beta is sufficient to rescue myotubular myopathy in mice.
Title: Inactivating the lipid kinase activity of PI3KC2β is sufficient to rescue myotubular myopathy in mice.
Uninephrectomy and class II PI3K-C2beta inactivation synergistically protect against obesity, insulin resistance and liver steatosis in mice.
Title: Uninephrectomy and class II PI3K-C2β inactivation synergistically protect against obesity, insulin resistance and liver steatosis in mice.
Class II phosphatidylinositol 3-kinase alpha and beta isoforms are required for vascular smooth muscle Rho activation, contraction and blood pressure regulation in mice.
Title: Class II phosphatidylinositol 3-kinase α and β isoforms are required for vascular smooth muscle Rho activation, contraction and blood pressure regulation in mice.
Both PI3K-C2alpha and PI3K-C2beta are required for normal uterine smooth muscle contraction and parturition mainly through their involvement in Rhoa activation.
Title: Class II PI3Ks α and β Are Required for Rho-Dependent Uterine Smooth Muscle Contraction and Parturition in Mice.
Pik3c2b is a genetic modifier of Mtm1 mutation with a role in function and survival in myotubular myopathy animal models
Title: PIK3C2B inhibition improves function and prolongs survival in myotubular myopathy animal models.
Modulation of PKA and PI3KC2beta activity to control of KCa3.1 channel expression can be an alternative important target to attenuate ascending thoracic aortic aneurysms in Fabry disease.
Title: Role of protein kinase A and class II phosphatidylinositol 3-kinase C2β in the downregulation of KCa3.1 channel synthesis and membrane surface expression by lyso-globotriaosylceramide.
study found that TRIM27 negatively regulates FcepsilonRI activation of KCa3.1 and downstream signaling by ubiquitinating and inhibiting PI3KC2beta
Title: Phosphatidylinositol-3-kinase C2β and TRIM27 function to positively and negatively regulate IgE receptor activation of mast cells.
These findings provide a unique mechanism for regulating class II PI3Ks, and identify TRIM27 as a previously undescribed negative regulator of CD4 T cells.
Title: Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2β.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-3-kinase activity	ISO Inferred from Sequence Orthology more info
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	ISO Inferred from Sequence Orthology more info
enables lipid kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within autophagosome organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to starvation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within macroautophagy	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphatidylinositol-3-phosphate biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of phosphatidylinositol 3-kinase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

Names: phosphoinositide-3-kinase, class 2, beta polypeptide

NP_001092746.2

EC 2.7.1.154

XP_006529594.1

EC 2.7.1.154

XP_006529595.1

EC 2.7.1.154

XP_006529596.1

EC 2.7.1.154

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001099276.2 → NP_001092746.2 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

See identical proteins and their annotated locations for NP_001092746.2

Status: VALIDATED

Source sequence(s)

AC107842, AC137948

Consensus CDS

CCDS48360.1

UniProtKB/TrEMBL

E9QAN8

Related

ENSMUSP00000076911.6, ENSMUST00000077730.7

Conserved Domains (6) summary

cd00895
Location:986 → 1339

PI3Kc_C2_beta; Catalytic domain of Class II Phosphoinositide 3-kinase beta

cd07290
Location:1368 → 1476

PX_PI3K_C2_beta; The phosphoinositide binding Phox Homology Domain of the Beta Isoform of Class II Phosphoinositide 3-Kinases

cd04012
Location:621 → 793

C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cd08381
Location:1504 → 1626

C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cd00869
Location:812 → 980

PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...

pfam00794
Location:363 → 465

PI3K_rbd; PI3-kinase family, ras-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

132973410..133036429

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006529532.2 → XP_006529595.1 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X1

See identical proteins and their annotated locations for XP_006529595.1

UniProtKB/TrEMBL

E9QAN8

Conserved Domains (6) summary

cd00895
Location:986 → 1339

PI3Kc_C2_beta; Catalytic domain of Class II Phosphoinositide 3-kinase beta

cd07290
Location:1368 → 1476

PX_PI3K_C2_beta; The phosphoinositide binding Phox Homology Domain of the Beta Isoform of Class II Phosphoinositide 3-Kinases

cd04012
Location:621 → 793

C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cd08381
Location:1504 → 1626

C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cd00869
Location:812 → 980

PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...

pfam00794
Location:363 → 465

PI3K_rbd; PI3-kinase family, ras-binding domain
XM_006529531.5 → XP_006529594.1 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X1

See identical proteins and their annotated locations for XP_006529594.1

UniProtKB/TrEMBL

E9QAN8

Conserved Domains (6) summary

cd00895
Location:986 → 1339

PI3Kc_C2_beta; Catalytic domain of Class II Phosphoinositide 3-kinase beta

cd07290
Location:1368 → 1476

PX_PI3K_C2_beta; The phosphoinositide binding Phox Homology Domain of the Beta Isoform of Class II Phosphoinositide 3-Kinases

cd04012
Location:621 → 793

C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cd08381
Location:1504 → 1626

C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cd00869
Location:812 → 980

PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...

pfam00794
Location:363 → 465

PI3K_rbd; PI3-kinase family, ras-binding domain
XM_006529533.5 → XP_006529596.1 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X2

Conserved Domains (6) summary

cd00895
Location:765 → 1118

PI3Kc_C2_beta; Catalytic domain of Class II Phosphoinositide 3-kinase beta

cd07290
Location:1147 → 1255

PX_PI3K_C2_beta; The phosphoinositide binding Phox Homology Domain of the Beta Isoform of Class II Phosphoinositide 3-Kinases

cd04012
Location:400 → 572

C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cd08381
Location:1283 → 1405

C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cd00869
Location:591 → 759

PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...

pfam00794
Location:142 → 244

PI3K_rbd; PI3-kinase family, ras-binding domain