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Taf10 TATA-box binding protein associated factor 10 [ Mus musculus (house mouse) ]

Gene ID: 24075, updated on 8-Dec-2022

Summary

Official Symbol
Taf10provided by MGI
Official Full Name
TATA-box binding protein associated factor 10provided by MGI
Primary source
MGI:MGI:1346320
See related
Ensembl:ENSMUSG00000043866 AllianceGenome:MGI:1346320
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
30kDa; Taf2h; TAFII30
Summary
Enables DNA binding activity and promoter-specific chromatin binding activity. Acts upstream of or within several processes, including G1/S transition of mitotic cell cycle; hepatocyte differentiation; and regulation of DNA binding activity. Located in nucleus. Is expressed in several structures, including blastocyst; embryo mesenchyme; gut; nervous system; and sensory organ epithelium. Orthologous to human TAF10 (TATA-box binding protein associated factor 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 258.4), duodenum adult (RPKM 245.3) and 28 other tissues See more
Orthologs
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Genomic context

See Taf10 in Genome Data Viewer
Location:
7; 7 E3
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (105392101..105393586, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (105742894..105744375, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene dynein heavy chain domain 1 Neighboring gene mitochondrial ribosomal protein S36, pseudogene 2 Neighboring gene ribosomal RNA processing 8 Neighboring gene integrin linked kinase Neighboring gene tripeptidyl peptidase I Neighboring gene uncharacterized LOC118567524 Neighboring gene dachsous cadherin related 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to RNA polymerase II general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to histone acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables promoter-specific chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription initiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in RNA polymerase II preinitiation complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in RNA polymerase II preinitiation complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in SAGA complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in allantois development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryo development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hepatocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in histone H3 acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in histone H3 acetylation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in histone acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone acetylation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lateral mesodermal cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in limb development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within liver development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in monoubiquitinated histone H2A deubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in monoubiquitinated histone deubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of transcription initiation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA repair NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of RNA splicing NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in somitogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transcription initiation at RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transcription initiation at RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of SAGA complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of SAGA complex ISO
Inferred from Sequence Orthology
more info
 
part_of SAGA complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IPI
Inferred from Physical Interaction
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of transcription factor TFIID complex ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of transcription factor TFIID complex TAS
Traceable Author Statement
more info
PubMed 
part_of transcription factor TFTC complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription factor TFTC complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of transcription preinitiation complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transcription initiation factor TFIID subunit 10
Names
TAF(II)30
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30 kDa
TAFII-30
TATA box binding protein (TBP)-associated factor, RNA polymerase II, H, 30 kDa
mTAFII30
transcription initiation factor TFIID 30 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020024.3NP_064408.2  transcription initiation factor TFIID subunit 10

    See identical proteins and their annotated locations for NP_064408.2

    Status: PROVISIONAL

    Source sequence(s)
    BC031418
    Consensus CDS
    CCDS21660.1
    UniProtKB/Swiss-Prot
    Q8K0H5, Q9QYY5
    Related
    ENSMUSP00000118105.2, ENSMUST00000141116.2
    Conserved Domains (1) summary
    cd07982
    Location:115217
    TAF10; The TATA Binding Protein (TBP) Associated Factor 10

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    105392101..105393586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507814.5XP_006507877.1  transcription initiation factor TFIID subunit 10 isoform X1

    Conserved Domains (2) summary
    PRK12323
    Location:4115
    PRK12323; DNA polymerase III subunit gamma/tau
    cl02150
    Location:115152
    TAF10; The TATA Binding Protein (TBP) Associated Factor 10