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Dusp5 dual specificity phosphatase 5 [ Mus musculus (house mouse) ]

Gene ID: 240672, updated on 21-Apr-2024

Summary

Official Symbol
Dusp5provided by MGI
Official Full Name
dual specificity phosphatase 5provided by MGI
Primary source
MGI:MGI:2685183
See related
Ensembl:ENSMUSG00000034765 AllianceGenome:MGI:2685183
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm337
Summary
Predicted to enable MAP kinase tyrosine/serine/threonine phosphatase activity and protein tyrosine/threonine phosphatase activity. Predicted to be involved in several processes, including endoderm formation; protein dephosphorylation; and regulation of blood circulation. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; cerebellum; lung; retina layer; and telencephalon mantle layer. Orthologous to human DUSP5 (dual specificity phosphatase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 25.5), duodenum adult (RPKM 24.5) and 19 other tissues See more
Orthologs
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Genomic context

Location:
19 D2; 19 47.98 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (53517576..53530240)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (53529145..53541809)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene myocardial infarction associated transcript 1 Neighboring gene RIKEN cDNA 4833407H14 gene Neighboring gene STARR-seq mESC enhancer starr_46456 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:53539230-53539416 Neighboring gene predicted gene, 30826 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:53577410-53577623 Neighboring gene STARR-positive B cell enhancer mm9_chr19:53603336-53603637 Neighboring gene predicted gene, 54049 Neighboring gene nuclear transport factor 2, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MAP kinase tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables MAP kinase tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables MAP kinase tyrosine/serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine/serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in endoderm formation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-threonine dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-tyrosine dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in peptidyl-tyrosine dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cerebral blood circulation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
dual specificity protein phosphatase 5
NP_001078859.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085390.2NP_001078859.1  dual specificity protein phosphatase 5

    See identical proteins and their annotated locations for NP_001078859.1

    Status: VALIDATED

    Source sequence(s)
    AC137853
    Consensus CDS
    CCDS38024.1
    UniProtKB/TrEMBL
    Q1HL35
    Related
    ENSMUSP00000047900.7, ENSMUST00000038287.7
    Conserved Domains (3) summary
    COG2453
    Location:227318
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
    cd00127
    Location:178314
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    cd01446
    Location:5140
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    53517576..53530240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)