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Kif20b kinesin family member 20B [ Mus musculus (house mouse) ]

Gene ID: 240641, updated on 18-Apr-2024

Summary

Official Symbol
Kif20bprovided by MGI
Official Full Name
kinesin family member 20Bprovided by MGI
Primary source
MGI:MGI:2444576
See related
Ensembl:ENSMUSG00000024795 AllianceGenome:MGI:2444576
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MPP1; 33cex; magoo; Mphosph1; C330014J10Rik
Summary
Predicted to enable several functions, including ATP hydrolysis activity; WW domain binding activity; and plus-end-directed microtubule motor activity. Involved in several processes, including positive regulation of mitotic cytokinetic process; positive regulation of neuron migration; and protein localization to microtubule. Acts upstream of or within neural tube closure; regulation of establishment of protein localization; and regulation of neuron migration. Located in several cellular components, including midbody; perinuclear region of cytoplasm; and spindle midzone. Is expressed in cerebral cortex marginal layer; cerebral cortex ventricular layer; cortical plate; and cortical subplate. Used to study microcephaly. Orthologous to human KIF20B (kinesin family member 20B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 8.8), liver E14 (RPKM 6.1) and 8 other tissues See more
Orthologs
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Genomic context

Location:
19 C1; 19 29.79 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (34899735..34953150)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (34922335..34975750)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22082 Neighboring gene pantothenate kinase 1 Neighboring gene microRNA 107 Neighboring gene STARR-positive B cell enhancer ABC_E2525 Neighboring gene STARR-seq mESC enhancer starr_46008 Neighboring gene STARR-seq mESC enhancer starr_46009 Neighboring gene STARR-seq mESC enhancer starr_46010 Neighboring gene microRNA 1950 Neighboring gene STARR-seq mESC enhancer starr_46011 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 5 pseudogene Neighboring gene predicted gene, 50137

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Chemically induced (ENU) (3)  1 citation
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • B130024C23

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
 
enables WW domain binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables plus-end-directed microtubule motor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mitotic cytokinetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to microtubule IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of establishment of cell polarity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of establishment of protein localization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of neuron migration IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in contractile ring ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle midzone ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle pole ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle midzone IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
kinesin-like protein KIF20B
Names
M-phase phosphoprotein 1
N-6 kinesin
kinesin-related motor interacting with PIN1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362434.1NP_001349363.1  kinesin-like protein KIF20B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113244, BC172148
    Consensus CDS
    CCDS89382.1
    UniProtKB/TrEMBL
    B7ZWN1
    Related
    ENSMUSP00000153034.2, ENSMUST00000223907.2
    Conserved Domains (3) summary
    cd01368
    Location:58475
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
    cl25574
    Location:14151701
    TOP2c; TopoisomeraseII
    cl25732
    Location:5271323
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_183046.2NP_898867.1  kinesin-like protein KIF20B isoform 1

    See identical proteins and their annotated locations for NP_898867.1

    Status: VALIDATED

    Source sequence(s)
    AC113244, AK045067, AK135856, AK143629, AK145779, AY259532
    Consensus CDS
    CCDS37967.1
    UniProtKB/Swiss-Prot
    E9QPW5, Q3V347, Q80VC0, Q80WE4, Q8BLI2, Q99PT5
    Related
    ENSMUSP00000084599.6, ENSMUST00000087341.7
    Conserved Domains (3) summary
    COG1196
    Location:6271492
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PTZ00108
    Location:14551741
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    cd01368
    Location:58475
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    34899735..34953150
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527082.4XP_006527145.1  kinesin-like protein KIF20B isoform X2

    Conserved Domains (3) summary
    COG1196
    Location:6271492
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PTZ00108
    Location:14551707
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    cd01368
    Location:58475
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
  2. XM_036161594.1XP_036017487.1  kinesin-like protein KIF20B isoform X3

    Conserved Domains (4) summary
    PTZ00121
    Location:10851512
    PTZ00121; MAEBL; Provisional
    PTZ00108
    Location:14151667
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    TIGR02168
    Location:5271291
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01368
    Location:58475
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
  3. XM_006527081.4XP_006527144.1  kinesin-like protein KIF20B isoform X1

    See identical proteins and their annotated locations for XP_006527144.1

    UniProtKB/Swiss-Prot
    E9QPW5, Q3V347, Q80VC0, Q80WE4, Q8BLI2, Q99PT5
    Conserved Domains (3) summary
    COG1196
    Location:6271492
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PTZ00108
    Location:14551741
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    cd01368
    Location:58475
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
  4. XM_030250939.2XP_030106799.1  kinesin-like protein KIF20B isoform X5

    Conserved Domains (3) summary
    PTZ00108
    Location:10291315
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    TIGR02168
    Location:141937
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl22853
    Location:189
    Motor_domain; Myosin and Kinesin motor domain
  5. XM_006527084.5XP_006527147.1  kinesin-like protein KIF20B isoform X4

    See identical proteins and their annotated locations for XP_006527147.1

    Conserved Domains (4) summary
    COG5059
    Location:2257
    KIP1; Kinesin-like protein [Cytoskeleton]
    PTZ00108
    Location:10691355
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    TIGR02168
    Location:287977
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl22853
    Location:189
    Motor_domain; Myosin and Kinesin motor domain
  6. XM_006527080.3XP_006527143.1  kinesin-like protein KIF20B isoform X1

    See identical proteins and their annotated locations for XP_006527143.1

    UniProtKB/Swiss-Prot
    E9QPW5, Q3V347, Q80VC0, Q80WE4, Q8BLI2, Q99PT5
    Conserved Domains (3) summary
    COG1196
    Location:6271492
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PTZ00108
    Location:14551741
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    cd01368
    Location:58475
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup

RNA

  1. XR_004940144.1 RNA Sequence

  2. XR_004940145.1 RNA Sequence

  3. XR_004940147.1 RNA Sequence