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Kcnv2 potassium channel, subfamily V, member 2 [ Mus musculus (house mouse) ]

Gene ID: 240595, updated on 18-Sep-2024

Summary

Official Symbol
Kcnv2provided by MGI
Official Full Name
potassium channel, subfamily V, member 2provided by MGI
Primary source
MGI:MGI:2670981
See related
Ensembl:ENSMUSG00000047298 AllianceGenome:MGI:2670981
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KV11.1
Summary
Predicted to enable voltage-gated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to act upstream of or within potassium ion transport and regulation of ion transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be integral component of membrane. Is expressed in several structures, including central nervous system; heart; and retina. Orthologous to human KCNV2 (potassium voltage-gated channel modifier subfamily V member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 1.7), testis adult (RPKM 0.5) and 3 other tissues See more
Orthologs
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Genomic context

See Kcnv2 in Genome Data Viewer
Location:
19 C1; 19 21.88 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (27299461..27314579)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (27322061..27337179)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35438 Neighboring gene STARR-seq mESC enhancer starr_45839 Neighboring gene very low density lipoprotein receptor Neighboring gene STARR-seq mESC enhancer starr_45840 Neighboring gene STARR-seq mESC enhancer starr_45841 Neighboring gene STARR-seq mESC enhancer starr_45842 Neighboring gene predicted gene, 35268 Neighboring gene STARR-seq mESC enhancer starr_45843 Neighboring gene predicted gene, 35554 Neighboring gene predicted gene, 50113

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Clone Names

  • MGC38990

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of voltage-gated potassium channel complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
potassium voltage-gated channel subfamily V member 2
Names
voltage-gated potassium channel subunit Kv8.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183179.1NP_899002.1  potassium voltage-gated channel subfamily V member 2

    See identical proteins and their annotated locations for NP_899002.1

    Status: VALIDATED

    Source sequence(s)
    BC039042
    Consensus CDS
    CCDS29722.1
    UniProtKB/Swiss-Prot
    Q8CFS6
    Related
    ENSMUSP00000055091.4, ENSMUST00000056708.4
    Conserved Domains (4) summary
    smart00225
    Location:107198
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:305521
    Ion_trans; Ion transport protein
    pfam07885
    Location:434509
    Ion_trans_2; Ion channel
    cl02518
    Location:107198
    BTB; BTB/POZ domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    27299461..27314579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527067.4XP_006527130.1  potassium voltage-gated channel subfamily V member 2 isoform X1

    Conserved Domains (2) summary
    cl38908
    Location:107214
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:276361
    Ion_trans; Ion transport protein