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Sh3bp5 SH3-domain binding protein 5 (BTK-associated) [ Mus musculus (house mouse) ]

Gene ID: 24056, updated on 8-May-2024

Summary

Official Symbol
Sh3bp5provided by MGI
Official Full Name
SH3-domain binding protein 5 (BTK-associated)provided by MGI
Primary source
MGI:MGI:1344391
See related
Ensembl:ENSMUSG00000021892 AllianceGenome:MGI:1344391
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sab; SH3BP-5
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and protein kinase inhibitor activity. Involved in negative regulation of protein kinase activity. Predicted to be located in cytoplasmic vesicle membrane; mitochondrion; and nuclear body. Predicted to be active in cytoplasm. Orthologous to human SH3BP5 (SH3 domain binding protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 46.1), CNS E14 (RPKM 37.5) and 25 other tissues See more
Orthologs
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Genomic context

See Sh3bp5 in Genome Data Viewer
Location:
14 19.11 cM; 14 B
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (31094571..31158056, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (31372614..31436100, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene dynein, axonemal, heavy chain 1 Neighboring gene predicted gene, 35823 Neighboring gene STARR-positive B cell enhancer ABC_E10823 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:32149566-32149675 Neighboring gene calpain 7 Neighboring gene STARR-seq mESC enhancer starr_36314 Neighboring gene STARR-positive B cell enhancer mm9_chr14:32229701-32230002 Neighboring gene predicted gene, 35907 Neighboring gene STARR-positive B cell enhancer ABC_E7303 Neighboring gene PRELI domain-containing protein 2 pseudogene Neighboring gene methyltransferase 6, methylcytidine Neighboring gene STARR-seq mESC enhancer starr_36316 Neighboring gene ELL associated factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding TAS
Traceable Author Statement
more info
PubMed 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in negative regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IC
Inferred by Curator
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
SH3 domain-binding protein 5
Names
SH3 domain-binding protein that preferentially associates with BTK

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347585.2NP_001334514.1  SH3 domain-binding protein 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC108416, AC154616
    Consensus CDS
    CCDS84108.1
    UniProtKB/Swiss-Prot
    Q3TTD6, Q8C903, Q8VCZ0, Q9Z131
    Related
    ENSMUSP00000098296.4, ENSMUST00000100730.10
  2. NM_001404586.1NP_001391515.1  SH3 domain-binding protein 5 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC108416, AC154616
  3. NM_001404587.1NP_001391516.1  SH3 domain-binding protein 5 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC108416, AC154616
  4. NM_001404588.1NP_001391517.1  SH3 domain-binding protein 5 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC108416, AC154616
  5. NM_001404589.1NP_001391518.1  SH3 domain-binding protein 5 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC108416, AC154616
  6. NM_011894.4NP_036024.2  SH3 domain-binding protein 5 isoform 1

    See identical proteins and their annotated locations for NP_036024.2

    Status: VALIDATED

    Source sequence(s)
    AC108416, AC154616
    Consensus CDS
    CCDS36855.1
    UniProtKB/Swiss-Prot
    Q3TTD6, Q8C903, Q8VCZ0, Q9Z131
    Related
    ENSMUSP00000089517.5, ENSMUST00000091903.5
    Conserved Domains (1) summary
    pfam05276
    Location:44270
    SH3BP5; SH3 domain-binding protein 5 (SH3BP5)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    31094571..31158056 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247814.1XP_030103674.1  SH3 domain-binding protein 5 isoform X1

    Conserved Domains (1) summary
    pfam05276
    Location:1112
    SH3BP5; SH3 domain-binding protein 5 (SH3BP5)
  2. XM_030247815.1XP_030103675.1  SH3 domain-binding protein 5 isoform X1

    Conserved Domains (1) summary
    pfam05276
    Location:1112
    SH3BP5; SH3 domain-binding protein 5 (SH3BP5)