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Cdc42bpg CDC42 binding protein kinase gamma [ Mus musculus (house mouse) ]

Gene ID: 240505, updated on 27-Nov-2024

Summary

Official Symbol
Cdc42bpgprovided by MGI
Official Full Name
CDC42 binding protein kinase gammaprovided by MGI
Primary source
MGI:MGI:2652845
See related
Ensembl:ENSMUSG00000024769 AllianceGenome:MGI:2652845
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MRCKgamma
Summary
Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Predicted to be involved in actomyosin structure organization and protein phosphorylation. Predicted to be located in cell leading edge; centriolar satellite; and cytosol. Predicted to be active in cytoplasm and cytoskeleton. Orthologous to human CDC42BPG (CDC42 binding protein kinase gamma). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in lung adult (RPKM 55.3), colon adult (RPKM 31.8) and 16 other tissues See more
Orthologs
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Genomic context

See Cdc42bpg in Genome Data Viewer
Location:
19 A; 19 4.43 cM
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6356465..6375682)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6306253..6325653)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene 14963 Neighboring gene STARR-positive B cell enhancer ABC_E8732 Neighboring gene EH-domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_45427 Neighboring gene predicted gene, 52380 Neighboring gene STARR-positive B cell enhancer ABC_E5682 Neighboring gene STARR-positive B cell enhancer ABC_E11670 Neighboring gene STARR-positive B cell enhancer ABC_E3239 Neighboring gene STARR-positive B cell enhancer ABC_E11015 Neighboring gene multiple endocrine neoplasia 1 Neighboring gene mitogen-activated protein kinase kinase kinase kinase 2 Neighboring gene microRNA 6989

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
 
located_in cell leading edge ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
 
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase MRCK gamma
Names
CDC42 binding protein kinase gamma (DMPK-like)
DMPK-like gamma
MRCK gamma
myotonic dystrophy kinase-related CDC42-binding kinase gamma
myotonic dystrophy protein kinase-like alpha
myotonic dystrophy protein kinase-like gamma
NP_001028514.1
XP_036017481.1
XP_036017482.1
XP_036017483.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033342.1NP_001028514.1  serine/threonine-protein kinase MRCK gamma

    See identical proteins and their annotated locations for NP_001028514.1

    Status: VALIDATED

    Source sequence(s)
    AC127556
    Consensus CDS
    CCDS50365.1
    UniProtKB/Swiss-Prot
    Q80UW5
    Related
    ENSMUSP00000025681.8, ENSMUST00000025681.8
    Conserved Domains (7) summary
    pfam08826
    Location:743798
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:71337
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01243
    Location:9371069
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:69399
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:878926
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:10961359
    CNH; CNH domain
    pfam09728
    Location:452774
    Taxilin; Myosin-like coiled-coil protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    6356465..6375682
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161588.1XP_036017481.1  serine/threonine-protein kinase MRCK gamma isoform X1

    Conserved Domains (5) summary
    cd01243
    Location:9371069
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:69399
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    TIGR02168
    Location:444802
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00780
    Location:10961359
    CNH; CNH domain
    cd20866
    Location:878929
    C1_MRCKgamma; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase gamma (MRCK gamma) and similar proteins
  2. XM_036161589.1XP_036017482.1  serine/threonine-protein kinase MRCK gamma isoform X2

    Conserved Domains (5) summary
    cd01243
    Location:9361068
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:69399
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    TIGR02168
    Location:444802
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00780
    Location:10951358
    CNH; CNH domain
    cd20866
    Location:877928
    C1_MRCKgamma; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase gamma (MRCK gamma) and similar proteins
  3. XM_036161590.1XP_036017483.1  serine/threonine-protein kinase MRCK gamma isoform X3

    Conserved Domains (4) summary
    cd01243
    Location:9371069
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:69399
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    TIGR02168
    Location:444802
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd20866
    Location:878929
    C1_MRCKgamma; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase gamma (MRCK gamma) and similar proteins