Malt1 MALT1 paracaspase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Malt1provided by MGI
Official Full Name: MALT1 paracaspaseprovided by MGI
Primary source: MGI:MGI:2445027
See related: Ensembl:ENSMUSG00000032688 AllianceGenome:MGI:2445027
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pcasp1; A630046N12; D430033E09Rik
Summary: Enables protease binding activity. Involved in several processes, including innate immune response; lipopolysaccharide-mediated signaling pathway; and positive regulation of immune response. Acts upstream of or within several processes, including B-1 B cell differentiation; positive regulation of NF-kappaB transcription factor activity; and regulation of T cell receptor signaling pathway. Located in cytosol. Part of polkadots. Is expressed in nervous system and neural retina. Human ortholog(s) of this gene implicated in immunodeficiency 12; lymphoma; and non-Hodgkin lymphoma. Orthologous to human MALT1 (MALT1 paracaspase). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Ubiquitous expression in spleen adult (RPKM 11.3), mammary gland adult (RPKM 4.9) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 E1; 18 38.56 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (65564010..65612138)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (65430939..65478888)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of the MALT1-LPCAT3 axis protects cartilage degeneration and osteoarthritis.
Title: Inhibition of the MALT1-LPCAT3 axis protects cartilage degeneration and osteoarthritis.
Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity.
Title: Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity.
Normal lymphocyte homeostasis and function in MALT1 protease-resistant HOIL-1 knock-in mice.
Title: Normal lymphocyte homeostasis and function in MALT1 protease-resistant HOIL-1 knock-in mice.
TRAF6 controls T cell homeostasis by maintaining the equilibrium of MALT1 scaffolding and protease functions.
Title: TRAF6 controls T cell homeostasis by maintaining the equilibrium of MALT1 scaffolding and protease functions.
Card9 protects fungal peritonitis through regulating Malt1-mediated activation of autophagy in macrophage.
Title: Card9 protects fungal peritonitis through regulating Malt1-mediated activation of autophagy in macrophage.
Keratinocyte-intrinsic BCL10/MALT1 activity initiates and amplifies psoriasiform skin inflammation.
Title: Keratinocyte-intrinsic BCL10/MALT1 activity initiates and amplifies psoriasiform skin inflammation.
TRAF6 prevents fatal inflammation by homeostatic suppression of MALT1 protease.
Title: TRAF6 prevents fatal inflammation by homeostatic suppression of MALT1 protease.
MALT1 protease function in regulatory T cells induces MYC activity to promote mitochondrial function and cellular expansion.
Title: MALT1 protease function in regulatory T cells induces MYC activity to promote mitochondrial function and cellular expansion.
MALT-1 inhibition attenuates the inflammatory response of ankylosing spondylitis by targeting NF-kappaB activation.
Title: MALT-1 inhibition attenuates the inflammatory response of ankylosing spondylitis by targeting NF-κB activation.
Intrinsic Abnormalities of Keratinocytes Initiate Skin Inflammation through the IL-23/T17 Axis in a MALT1-Dependent Manner.
Title: Intrinsic Abnormalities of Keratinocytes Initiate Skin Inflammation through the IL-23/T17 Axis in a MALT1-Dependent Manner.

Submit: New GeneRIF Correction See all GeneRIFs (65)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (3)
Endonuclease-mediated (4) 1 citation
Targeted (12) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables endopeptidase activator activity	IEA Inferred from Electronic Annotation more info
enables endopeptidase activator activity	ISO Inferred from Sequence Orthology more info
enables endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
contributes_to kinase activator activity	IEA Inferred from Electronic Annotation more info
contributes_to kinase activator activity	ISO Inferred from Sequence Orthology more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small molecule binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell activation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within B cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within B-1 B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in T cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in T cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic process	RCA inferred from Reviewed Computational Analysis more info	PubMed
acts_upstream_of_or_within canonical NF-kappaB signal transduction	RCA inferred from Reviewed Computational Analysis more info	PubMed
involved_in cell development	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in immune system process	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IEP Inferred from Expression Pattern more info	PubMed
involved_in lipopolysaccharide-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in nuclear export	IEA Inferred from Electronic Annotation more info
involved_in nuclear export	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T cell cytokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 17 cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of immune effector process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-1 beta production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-2 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of multicellular organismal process	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis involved in protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteolysis involved in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteolysis involved in protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of T cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of apoptotic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of CBM complex	IEA Inferred from Electronic Annotation more info
part_of CBM complex	ISO Inferred from Sequence Orthology more info
part_of CBM complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
part_of polkadots	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog

Names: mucosa associated lymphoid tissue lymphoma translocation gene 1; paracaspase-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001365019.2 → NP_001351948.1 mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog isoform 2

Status: VALIDATED

Source sequence(s)

AC102240

Consensus CDS

CCDS89264.1

UniProtKB/Swiss-Prot

Q2TBA2, Q2TBA3, Q811E3, Q8BFT0, Q8C7N9

Related

ENSMUSP00000153585.2, ENSMUST00000224056.3

Conserved Domains (3) summary

cd08783
Location:36 → 132

Death_MALT1; Death domain similar to that found in Mucosa-associated lymphoid tissue-lymphoma-translocation gene 1

pfam00656
Location:351 → 568

Peptidase_C14; Caspase domain

pfam13927
Location:130 → 200

Ig_3; Immunoglobulin domain
NM_172833.4 → NP_766421.1 mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog isoform 1

See identical proteins and their annotated locations for NP_766421.1

Status: VALIDATED

Source sequence(s)

AC102240

Consensus CDS

CCDS29306.1

UniProtKB/Swiss-Prot

Q2TBA3

Related

ENSMUSP00000048376.6, ENSMUST00000049248.7

Conserved Domains (4) summary

smart00410
Location:139 → 207

IG_like; Immunoglobulin like

cd08783
Location:36 → 132

Death_MALT1; Death domain similar to that found in Mucosa-associated lymphoid tissue-lymphoma-translocation gene 1

pfam00656
Location:340 → 557

Peptidase_C14; Caspase domain

pfam13895
Location:133 → 207

Ig_2; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

65564010..65612138

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161142.1 → XP_036017035.1 mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog isoform X4
XM_006525941.4 → XP_006526004.1 mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog isoform X3

Conserved Domains (2) summary

pfam00656
Location:3 → 210

Peptidase_C14; Caspase domain

pfam18703
Location:233 → 369

MALT1_Ig; MALT1 Ig-like domain
XM_036161140.1 → XP_036017033.1 mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog isoform X1
XM_006525940.5 → XP_006526003.1 mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog isoform X2

Conserved Domains (2) summary

pfam00656
Location:13 → 230

Peptidase_C14; Caspase domain

pfam18703
Location:253 → 389

MALT1_Ig; MALT1 Ig-like domain