Dmxl1 Dmx-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dmxl1provided by MGI
Official Full Name: Dmx-like 1provided by MGI
Primary source: MGI:MGI:2443926
See related: Ensembl:ENSMUSG00000037416 AllianceGenome:MGI:2443926
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D030030C22; C630007L23Rik
Summary: Predicted to be involved in vacuolar acidification. Predicted to be part of RAVE complex. Orthologous to human DMXL1 (Dmx like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 4.7), cerebellum adult (RPKM 3.5) and 28 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 18; 18 D1

Exon count:: 45

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (49965657..50098540)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (49832590..49965473)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

px-31f3 (e-PCR)
- UniSTS:257585

D18Mit24 (e-PCR), detects polymorphism
- UniSTS:116574

D3Mit262.1 (e-PCR), detects polymorphism
- UniSTS:129691

Homology

Homologs of the Dmxl1 gene: The Dmxl1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 339 organisms have orthologs with human gene Dmxl1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in vacuolar acidification	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
part_of RAVE complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: dmX-like protein 1

Names: X-like 1 protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081371.2 → NP_001074840.2 dmX-like protein 1

See identical proteins and their annotated locations for NP_001074840.2

Status: VALIDATED

Source sequence(s)

AC113451, AC166570, AEKQ02092752

Consensus CDS

CCDS37816.2

UniProtKB/Swiss-Prot

Q6PNC0, Q8BQF2

Related

ENSMUSP00000137871.2, ENSMUST00000180611.8

Conserved Domains (4) summary

COG2319
Location:2766 → 3008

WD40; WD40 repeat [General function prediction only]

pfam12234
Location:1139 → 1875

Rav1p_C; RAVE protein 1 C terminal

sd00039
Location:2777 → 2822

7WD40; WD40 repeat [structural motif]

cl02567
Location:2733 → 2990

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

49965657..50098540

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006525916.4 → XP_006525979.1 dmX-like protein 1 isoform X1

Conserved Domains (3) summary

sd00039
Location:2836 → 2881

7WD40; WD40 repeat [structural motif]

pfam12234
Location:1139 → 1875

Rav1p_C; RAVE protein 1 C terminal

cl29593
Location:2792 → 3049

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006525917.4 → XP_006525980.1 dmX-like protein 1 isoform X2

Conserved Domains (3) summary

sd00039
Location:2815 → 2860

7WD40; WD40 repeat [structural motif]

pfam12234
Location:1139 → 1875

Rav1p_C; RAVE protein 1 C terminal

cl29593
Location:2771 → 3028

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006525918.4 → XP_006525981.1 dmX-like protein 1 isoform X3

Conserved Domains (3) summary

sd00039
Location:2798 → 2843

7WD40; WD40 repeat [structural motif]

pfam12234
Location:1139 → 1875

Rav1p_C; RAVE protein 1 C terminal

cl29593
Location:2754 → 3011

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_030250455.1 → XP_030106315.1 dmX-like protein 1 isoform X4

Conserved Domains (3) summary

sd00039
Location:2679 → 2724

7WD40; WD40 repeat [structural motif]

pfam12234
Location:982 → 1718

Rav1p_C; RAVE protein 1 C terminal

cl29593
Location:2635 → 2892

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...