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St6gal2 beta galactoside alpha 2,6 sialyltransferase 2 [ Mus musculus (house mouse) ]

Gene ID: 240119, updated on 5-Mar-2024

Summary

Official Symbol
St6gal2provided by MGI
Official Full Name
beta galactoside alpha 2,6 sialyltransferase 2provided by MGI
Primary source
MGI:MGI:2445190
See related
Ensembl:ENSMUSG00000024172 AllianceGenome:MGI:2445190
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
St6galII; mKIAA1877; C230064G14Rik
Summary
Enables sialyltransferase activity. Predicted to be involved in oligosaccharide metabolic process. Predicted to act upstream of or within N-acetylneuraminate metabolic process. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Is expressed in several structures, including brain; genitourinary system; lung; skeletal muscle; and spleen. Orthologous to human ST6GAL2 (ST6 beta-galactoside alpha-2,6-sialyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 9.2), whole brain E14.5 (RPKM 5.1) and 6 other tissues See more
Orthologs
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Genomic context

See St6gal2 in Genome Data Viewer
Location:
17 C; 17 28.82 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (55752071..55821582)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (55445118..55514581)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42865 Neighboring gene nuclear transport factor 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_42866 Neighboring gene STARR-seq mESC enhancer starr_42867 Neighboring gene predicted gene 4471 Neighboring gene STARR-seq mESC enhancer starr_42868 Neighboring gene vomeronasal 2, receptor 118 Neighboring gene predicted gene, 22654 Neighboring gene protection of telomeres 1B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-galactoside alpha-2,6-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables beta-galactoside alpha-2,6-sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables sialyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within N-acetylneuraminate metabolic process IC
Inferred by Curator
more info
PubMed 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in oligosaccharide metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
 
involved_in sialylation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
beta-galactoside alpha-2,6-sialyltransferase 2
Names
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2
beta-galactoside alpha-2,6-sialyltransferase II
NP_001334332.1
XP_006524330.1
XP_006524331.1
XP_006524332.1
XP_030105661.1
XP_030105662.1
XP_036016499.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347403.1NP_001334332.1  beta-galactoside alpha-2,6-sialyltransferase 2

    Status: VALIDATED

    Source sequence(s)
    BE991433, CT009635
    Consensus CDS
    CCDS84324.1
    UniProtKB/Swiss-Prot
    A9C434, Q6ZPG5, Q76K27, Q8BUU4
    UniProtKB/TrEMBL
    B2RQY9
    Related
    ENSMUSP00000025000.4, ENSMUST00000025000.4
    Conserved Domains (1) summary
    pfam00777
    Location:276506
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    55752071..55821582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524267.4XP_006524330.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_006524330.1

    UniProtKB/Swiss-Prot
    A9C434, Q6ZPG5, Q76K27, Q8BUU4
    UniProtKB/TrEMBL
    B2RQY9
    Conserved Domains (1) summary
    pfam00777
    Location:276506
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. XM_030249801.2XP_030105661.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1

    UniProtKB/Swiss-Prot
    A9C434, Q6ZPG5, Q76K27, Q8BUU4
    UniProtKB/TrEMBL
    B2RQY9
    Conserved Domains (1) summary
    pfam00777
    Location:276506
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  3. XM_006524268.4XP_006524331.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_006524331.1

    UniProtKB/Swiss-Prot
    A9C434, Q6ZPG5, Q76K27, Q8BUU4
    UniProtKB/TrEMBL
    B2RQY9
    Conserved Domains (1) summary
    pfam00777
    Location:276506
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  4. XM_030249802.2XP_030105662.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1

    UniProtKB/Swiss-Prot
    A9C434, Q6ZPG5, Q76K27, Q8BUU4
    UniProtKB/TrEMBL
    B2RQY9
    Conserved Domains (1) summary
    pfam00777
    Location:276506
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  5. XM_006524269.3XP_006524332.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_006524332.1

    UniProtKB/Swiss-Prot
    A9C434, Q6ZPG5, Q76K27, Q8BUU4
    UniProtKB/TrEMBL
    B2RQY9
    Conserved Domains (1) summary
    pfam00777
    Location:276506
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  6. XM_036160606.1XP_036016499.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1

    UniProtKB/Swiss-Prot
    A9C434, Q6ZPG5, Q76K27, Q8BUU4
    UniProtKB/TrEMBL
    B2RQY9
    Conserved Domains (1) summary
    pfam00777
    Location:276506
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RNA

  1. XR_004939531.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_172829.2: Suppressed sequence

    Description
    NM_172829.2: This RefSeq was removed because currently there is insufficient support for the transcript and protein.