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Ik IK cytokine [ Mus musculus (house mouse) ]

Gene ID: 24010, updated on 30-Apr-2024

Summary

Official Symbol
Ikprovided by MGI
Official Full Name
IK cytokineprovided by MGI
Primary source
MGI:MGI:1345142
See related
Ensembl:ENSMUSG00000024474 AllianceGenome:MGI:1345142
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MuRED
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in mRNA splicing, via spliceosome; mitotic spindle assembly checkpoint signaling; and protein localization to kinetochore. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nuclear speck. Predicted to be part of U2-type precatalytic spliceosome. Predicted to be active in nucleus. Predicted to colocalize with mitotic spindle pole and nuclear chromosome. Is expressed in testis. Orthologous to human IK (IK cytokine). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 65.1), CNS E14 (RPKM 39.9) and 24 other tissues See more
Orthologs
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Genomic context

Location:
18 B2; 18 19.46 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (36877709..36890692)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (36744656..36757639)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene CD14 antigen Neighboring gene STARR-positive B cell enhancer ABC_E2505 Neighboring gene STARR-positive B cell enhancer ABC_E8709 Neighboring gene transmembrane and coiled-coil domains 6 Neighboring gene STARR-positive B cell enhancer ABC_E617 Neighboring gene NADH:ubiquinone oxidoreductase subunit A2 Neighboring gene WD repeat domain 55 Neighboring gene DND microRNA-mediated repression inhibitor 1 Neighboring gene histidyl-tRNA synthetase 1 Neighboring gene STARR-positive B cell enhancer ABC_E8710 Neighboring gene histidyl-tRNA synthetase 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic spindle assembly checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to kinetochore ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of U2-type precatalytic spliceosome ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with mitotic spindle pole ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with nuclear chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein Red
Names
IK factor
arginine/glutamic acid/aspartic acid repeat containing protein
cytokine IK

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011879.2NP_036009.1  protein Red

    See identical proteins and their annotated locations for NP_036009.1

    Status: VALIDATED

    Source sequence(s)
    BC029694, BG084120, BM211698
    Consensus CDS
    CCDS57119.1
    UniProtKB/Swiss-Prot
    Q8R0P0, Q95H93, Q9Z1M8
    UniProtKB/TrEMBL
    Q8C2T9
    Related
    ENSMUST00000224284.3
    Conserved Domains (2) summary
    pfam07807
    Location:445554
    RED_C; RED-like protein C-terminal region
    pfam07808
    Location:83295
    RED_N; RED-like protein N-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    36877709..36890692
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)