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H2-M5 histocompatibility 2, M region locus 5 [ Mus musculus (house mouse) ]

Gene ID: 240095, updated on 8-Feb-2024

Summary

Official Symbol
H2-M5provided by MGI
Official Full Name
histocompatibility 2, M region locus 5provided by MGI
Primary source
MGI:MGI:95917
See related
Ensembl:ENSMUSG00000024459 AllianceGenome:MGI:95917
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CRW2; H-2M5; D130003B22Rik
Summary
Predicted to enable several functions, including 14-3-3 protein binding activity; TAP binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and positive regulation of T cell mediated cytotoxicity. Predicted to be located in several cellular components, including bounding membrane of organelle; cell surface; and endoplasmic reticulum. Predicted to be part of MHC class I protein complex and MHC class Ib protein complex. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in brain and thymus. Human ortholog(s) of this gene implicated in asthma; hepatitis C; and occupational asthma. Orthologous to human HLA-E (major histocompatibility complex, class I, E); HLA-F (major histocompatibility complex, class I, F); and HLA-G (major histocompatibility complex, class I, G). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E14 (RPKM 5.5), whole brain E14.5 (RPKM 5.1) and 9 other tissues See more
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Genomic context

See H2-M5 in Genome Data Viewer
Location:
17 B1; 17 19.16 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (37294677..37308847, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (36983785..36997955, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42496 Neighboring gene histocompatibility 2, M region locus 6, pseudogene Neighboring gene RIKEN cDNA 2410137M14 gene Neighboring gene histocompatibility 2, M region locus 4, pseudogene Neighboring gene STARR-seq mESC enhancer starr_42498 Neighboring gene STARR-seq mESC enhancer starr_42499 Neighboring gene zinc finger protein 57 Neighboring gene myelin oligodendrocyte glycoprotein Neighboring gene STARR-seq mESC enhancer starr_42503 Neighboring gene STARR-seq mESC enhancer starr_42504 Neighboring gene gamma-aminobutyric acid type B receptor subunit 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables CD8 receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables MHC class I protein binding ISO
Inferred from Sequence Orthology
more info
 
enables T cell receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables TAP1 binding ISO
Inferred from Sequence Orthology
more info
 
enables TAP2 binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-2-microglobulin binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables natural killer cell lectin-like receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables peptide antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peptide antigen binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in CD8-positive, alpha-beta T cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in adaptive immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in antibacterial humoral response ISO
Inferred from Sequence Orthology
more info
 
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib ISO
Inferred from Sequence Orthology
more info
 
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class Ib ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in natural killer cell tolerance induction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of natural killer cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of CD8-positive, alpha-beta T cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of CD8-positive, alpha-beta T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell mediated cytotoxicity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of T cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of TRAIL production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of antibody-dependent cellular cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of immunoglobulin production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-13 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-4 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of natural killer cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of natural killer cell cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of natural killer cell mediated immunity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of natural killer cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in protection from natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of natural killer cell mediated immunity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
part_of MHC class I protein complex ISO
Inferred from Sequence Orthology
more info
 
part_of MHC class Ib protein complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cis-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
histocompatibility 2, M region locus 5
Names
MHC class I like protein M5
MHC classIb protein M5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001115075.2NP_001108547.1  histocompatibility 2, M region locus 5 precursor

    See identical proteins and their annotated locations for NP_001108547.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AB359228, CR956641
    Consensus CDS
    CCDS50105.1
    UniProtKB/TrEMBL
    A7VMS3, H3BK58
    Related
    ENSMUSP00000131365.2, ENSMUST00000169189.8
    Conserved Domains (2) summary
    cd07698
    Location:208300
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam00129
    Location:26204
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RNA

  1. NR_160897.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CR956641
  2. NR_160898.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CR956641

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    37294677..37308847 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249800.2XP_030105660.1  histocompatibility 2, M region locus 5 isoform X1

    UniProtKB/TrEMBL
    H3BK58
    Related
    ENSMUSP00000135262.2, ENSMUST00000176784.8
    Conserved Domains (2) summary
    cd07698
    Location:172264
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam00129
    Location:1168
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2