U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Arid1b AT rich interactive domain 1B (SWI-like) [ Mus musculus (house mouse) ]

Gene ID: 239985, updated on 28-Dec-2022

Summary

Official Symbol
Arid1bprovided by MGI
Official Full Name
AT rich interactive domain 1B (SWI-like)provided by MGI
Primary source
MGI:MGI:1926129
See related
Ensembl:ENSMUSG00000069729 AllianceGenome:MGI:1926129
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ardi1b; BAF250B; mKIAA1235; 8030481M12; 9330189K18Rik; B230217J03Rik
Summary
Predicted to enable DNA binding activity. Predicted to contribute to nucleosome binding activity. Acts upstream of or within dendritic cell dendrite assembly; dendritic spine development; and neuron-neuron synaptic transmission. Located in nucleus. Part of nBAF complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study Coffin-Siris syndrome 1 and autism spectrum disorder. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome; Coffin-Siris syndrome 1; intellectual disability; lung non-small cell carcinoma; and neuroblastoma. Orthologous to human ARID1B (AT-rich interaction domain 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 12.5), ovary adult (RPKM 11.0) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Arid1b in Genome Data Viewer
Location:
17; 17 A1
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (5044481..5397931)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (4994297..5347656)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34507 Neighboring gene predicted gene, 41517 Neighboring gene predicted gene, 34625 Neighboring gene tubulin, alpha 1B pseudogene Neighboring gene predicted gene, 34854 Neighboring gene transmembrane protein 242 Neighboring gene predicted gene 29050 Neighboring gene lactate dehydrogenase A-like 6B Neighboring gene non-SMC condensin II complex, subunit H2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chromatin remodeling IC
Inferred by Curator
more info
PubMed 
involved_in chromatin remodeling NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within dendritic cell dendrite assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dendritic spine development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neuron-neuron synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of T cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of double-strand break repair NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of myoblast differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of G0 to G1 transition NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of G1/S transition of mitotic cell cycle NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of mitotic metaphase/anaphase transition NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of nucleotide-excision repair NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of SWI/SNF complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of SWI/SNF complex ISO
Inferred from Sequence Orthology
more info
 
part_of SWI/SNF complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of SWI/SNF superfamily-type complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of bBAF complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of brahma complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in chromatin NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of nBAF complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of nBAF complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of nBAF complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of npBAF complex NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
AT-rich interactive domain-containing protein 1B
Names
ARID domain-containing protein 1B
AT rich interactive domain 1B (Swi1 like)
BRG1-associated factor 250b

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085355.1NP_001078824.1  AT-rich interactive domain-containing protein 1B

    Status: VALIDATED

    Source sequence(s)
    AC126929, AC166064, BF462904, CK389103
    Consensus CDS
    CCDS49929.1
    UniProtKB/Swiss-Prot
    E9Q4N7
    UniProtKB/TrEMBL
    A0A8Q0PK87
    Related
    ENSMUSP00000111463.3, ENSMUST00000115797.9
    Conserved Domains (4) summary
    smart00501
    Location:10621149
    BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain
    pfam09606
    Location:11741555
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam12031
    Location:19352190
    BAF250_C; SWI/SNF-like complex subunit BAF250/Osa
    cl26464
    Location:451863
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    5044481..5397931
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523223.5XP_006523286.1  AT-rich interactive domain-containing protein 1B isoform X2

    See identical proteins and their annotated locations for XP_006523286.1

    Related
    ENSMUSP00000111465.2, ENSMUST00000115799.2
    Conserved Domains (4) summary
    pfam09606
    Location:7051086
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd16877
    Location:593685
    ARID_ARID1B; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 1B (ARID1B) and similar proteins
    pfam12031
    Location:14661721
    BAF250_C; SWI/SNF-like complex subunit BAF250/Osa
    pfam15362
    Location:163363
    Enamelin
  2. XM_006523221.5XP_006523284.2  AT-rich interactive domain-containing protein 1B isoform X1

    UniProtKB/Swiss-Prot
    E9Q4N7
    Related
    ENSMUSP00000090398.5, ENSMUST00000092723.11
    Conserved Domains (4) summary
    PHA03307
    Location:568923
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam09606
    Location:12371617
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd16877
    Location:11241216
    ARID_ARID1B; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 1B (ARID1B) and similar proteins
    pfam12031
    Location:19972252
    BAF250_C; SWI/SNF-like complex subunit BAF250/Osa