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Cadm2 cell adhesion molecule 2 [ Mus musculus (house mouse) ]

Gene ID: 239857, updated on 22-May-2018

Summary

Official Symbol
Cadm2provided by MGI
Official Full Name
cell adhesion molecule 2provided by MGI
Primary source
MGI:MGI:2442722
See related
Ensembl:ENSMUSG00000064115 Vega:OTTMUSG00000017090
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NECL3; Igdf4d; Igsf4d; SynCAM2; SynCAM 2; 9330131D06; 2900078E11Rik; A830029E02Rik
Expression
Biased expression in frontal lobe adult (RPKM 12.4), cortex adult (RPKM 11.9) and 5 other tissues See more
Orthologs

Genomic context

See Cadm2 in Genome Data Viewer
Location:
16; 16 C1.3-C2
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (66655416..67621202, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (66655666..67621153, complement)

Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene epidermal growth factor pseudogene Neighboring gene ribosomal protein 10 pseudogene Neighboring gene RIKEN cDNA 1700010K23 gene Neighboring gene RIKEN cDNA 9330155M09 gene Neighboring gene crumbs homolog 1 pseudogene Neighboring gene 40S ribosomal protein S27-like pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
axon ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cell adhesion molecule 2
Names
NECL-3
immunoglobulin superfamily member 4D
immunoglobulin superfamily, member 4
nectin-like protein 3
synaptic cell adhesion molecule 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145977.1NP_001139449.1  cell adhesion molecule 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001139449.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) is missing an in-frame coding exon compared to transcript variant 1, resulting in a shorter isoform (2) missing a 9 aa segment compared to isoform 1.
    Source sequence(s)
    AK033973, AK043760, AK165030, BB667048, BF458515, CT010571
    Consensus CDS
    CCDS49885.1
    UniProtKB/Swiss-Prot
    Q8BLQ9
    Related
    ENSMUSP00000113178.1, OTTMUSP00000032719, ENSMUST00000120898.7, OTTMUST00000065609
    Conserved Domains (4) summary
    smart00294
    Location:348366
    4.1m; putative band 4.1 homologues' binding motif
    pfam13927
    Location:227300
    Ig_3; Immunoglobulin domain
    cd05884
    Location:141223
    Ig2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
    cd07701
    Location:26120
    Ig1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
  2. NM_001347247.1NP_001334176.1  cell adhesion molecule 2 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' coding region and contains an exon in the 3' coding region compared to variant 1. The encoded isoform (3) is longer than isoform 1.
    Source sequence(s)
    AC105980, AC109233, AC154196, AC154428, CJ259603, CT010571
    Consensus CDS
    CCDS84251.1
    UniProtKB/Swiss-Prot
    Q8BLQ9
    Conserved Domains (4) summary
    smart00294
    Location:388406
    4.1m; putative band 4.1 homologues' binding motif
    pfam13927
    Location:227300
    Ig_3; Immunoglobulin domain
    cd05884
    Location:141223
    Ig2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
    cd07701
    Location:26120
    Ig1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
  3. NM_178721.4NP_848836.2  cell adhesion molecule 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_848836.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AK043760, AK165030, BB667048, BF458515, CT010571
    Consensus CDS
    CCDS28270.1
    UniProtKB/Swiss-Prot
    Q8BLQ9
    Related
    ENSMUSP00000109931.1, OTTMUSP00000018568, ENSMUST00000114292.7, OTTMUST00000041387
    Conserved Domains (4) summary
    smart00294
    Location:357375
    4.1m; putative band 4.1 homologues' binding motif
    pfam13927
    Location:236309
    Ig_3; Immunoglobulin domain
    cd05884
    Location:150232
    Ig2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
    cd07701
    Location:35129
    Ig1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

    Range
    66655416..67621202 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246128.2XP_011244430.1  cell adhesion molecule 2 isoform X1

    Conserved Domains (6) summary
    smart00294
    Location:411429
    4.1m; putative band 4.1 homologues' binding motif
    cd05884
    Location:164246
    Ig2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
    smart00408
    Location:263326
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:262336
    IG_like; Immunoglobulin like
    cl04449
    Location:956
    MtrA; Tetrahydromethanopterin S-methyltransferase, subunit A
    cl11960
    Location:49143
    Ig; Immunoglobulin domain
  2. XM_006523028.3XP_006523091.1  cell adhesion molecule 2 isoform X3

    Related
    ENSMUSP00000113500.1, OTTMUSP00000032720, ENSMUST00000120594.7, OTTMUST00000065610
    Conserved Domains (4) summary
    smart00294
    Location:388406
    4.1m; putative band 4.1 homologues' binding motif
    pfam13927
    Location:227300
    Ig_3; Immunoglobulin domain
    cd05884
    Location:141223
    Ig2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
    cd07701
    Location:26120
    Ig1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
  3. XM_006523026.3XP_006523089.1  cell adhesion molecule 2 isoform X2

    Related
    ENSMUSP00000134554.1, OTTMUSP00000053386, ENSMUST00000128168.2, OTTMUST00000065611
    Conserved Domains (5) summary
    smart00294
    Location:397415
    4.1m; putative band 4.1 homologues' binding motif
    cd05884
    Location:150232
    Ig2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
    smart00408
    Location:249312
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:248322
    IG_like; Immunoglobulin like
    cl11960
    Location:35129
    Ig; Immunoglobulin domain
  4. XM_011246129.2XP_011244431.1  cell adhesion molecule 2 isoform X4

    Conserved Domains (6) summary
    smart00294
    Location:371389
    4.1m; putative band 4.1 homologues' binding motif
    cd05884
    Location:164246
    Ig2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
    cd07701
    Location:49143
    Ig1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
    smart00408
    Location:263326
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:262336
    IG_like; Immunoglobulin like
    cl04449
    Location:956
    MtrA; Tetrahydromethanopterin S-methyltransferase, subunit A

RNA

  1. XR_001781826.1 RNA Sequence

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