Zpld1 zona pellucida like domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zpld1provided by MGI
Official Full Name: zona pellucida like domain containing 1provided by MGI
Primary source: MGI:MGI:2443415
See related: Ensembl:ENSMUSG00000064310 AllianceGenome:MGI:2443415
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 9430016A21Rik
Summary: Predicted to be an extracellular matrix structural constituent. Acts upstream of or within vestibular reflex. Predicted to be located in cytoplasmic vesicle; extracellular region; and membrane. Predicted to be integral component of membrane. Predicted to be active in cell surface and extracellular space. Is expressed in axial skeleton; cochlea; femur; fibula; and tibia. Orthologous to human ZPLD1 (zona pellucida like domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 16; 16 C1.1

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (55044488..55142403, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (55224125..55322025, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Spontaneous mutations of the Zpld1 gene in mice cause semicircular canal dysfunction but do not impair gravity receptor or hearing functions.
Title: Spontaneous mutations of the Zpld1 gene in mice cause semicircular canal dysfunction but do not impair gravity receptor or hearing functions.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (2) 1 citation
Endonuclease-mediated (2)

General gene information

Go to the top of the page Help

Markers

D16Mit221 (e-PCR), detects polymorphism
- UniSTS:127856

Homology

Homologs of the Zpld1 gene: The Zpld1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 344 organisms have orthologs with human gene Zpld1
Orthologs

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within vestibular reflex	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: zona pellucida-like domain-containing protein 1

Names: ZP domain-containing protein 1; cupulin

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417872.1 → NP_001404801.1 zona pellucida-like domain-containing protein 1 precursor

Status: VALIDATED

Source sequence(s)

AC155271
NM_178720.5 → NP_848835.1 zona pellucida-like domain-containing protein 1 precursor

See identical proteins and their annotated locations for NP_848835.1

Status: VALIDATED

Source sequence(s)

AC155271

Consensus CDS

CCDS28215.1

UniProtKB/Swiss-Prot

Q14BA1, Q8BGZ8

UniProtKB/TrEMBL

A0A8C6IEQ5

Related

ENSMUSP00000049012.4, ENSMUST00000036412.4

Conserved Domains (1) summary

pfam00100
Location:44 → 305

Zona_pellucida; Zona pellucida-like domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

55044488..55142403 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006522132.3 → XP_006522195.1 zona pellucida-like domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

Q14BA1, Q8BGZ8

UniProtKB/TrEMBL

A0A8C6IEQ5

Conserved Domains (1) summary

pfam00100
Location:44 → 305

Zona_pellucida; Zona pellucida-like domain