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Lmln leishmanolysin-like (metallopeptidase M8 family) [ Mus musculus (house mouse) ]

Gene ID: 239833, updated on 26-Sep-2022

Summary

Official Symbol
Lmlnprovided by MGI
Official Full Name
leishmanolysin-like (metallopeptidase M8 family)provided by MGI
Primary source
MGI:MGI:2444736
See related
Ensembl:ENSMUSG00000022802 AllianceGenome:MGI:2444736
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5330415H22Rik
Summary
Predicted to enable peptidase activity. Predicted to be involved in cell adhesion. Predicted to act upstream of or within cell division. Predicted to be located in cytosol and focal adhesion. Predicted to be active in cytoplasm. Orthologous to human LMLN (leishmanolysin like peptidase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 2.2), testis adult (RPKM 2.1) and 28 other tissues See more
Orthologs
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Genomic context

See Lmln in Genome Data Viewer
Location:
16; 16 B3
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (32881974..32948065)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (33061870..33127695)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene leucine-rich repeats and calponin homology (CH) domain containing 3 Neighboring gene IQ motif containing G Neighboring gene ribosomal protein L35A Neighboring gene microRNA 1947 Neighboring gene predicted gene, 38540 Neighboring gene predicted gene, 41447 Neighboring gene predicted gene, 53950

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leishmanolysin-like peptidase
NP_766411.1
XP_030104970.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172823.2NP_766411.1  leishmanolysin-like peptidase precursor

    See identical proteins and their annotated locations for NP_766411.1

    Status: PROVISIONAL

    Source sequence(s)
    AK030463
    Consensus CDS
    CCDS28127.1
    UniProtKB/Swiss-Prot
    Q8BMN4
    Related
    ENSMUSP00000023497.3, ENSMUST00000023497.3
    Conserved Domains (1) summary
    cl19482
    Location:96628
    Peptidase_M8; Leishmanolysin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    32881974..32948065
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249110.1XP_030104970.1  leishmanolysin-like peptidase isoform X1

    Conserved Domains (1) summary
    cl19482
    Location:2385
    Peptidase_M8; Leishmanolysin

RNA

  1. XR_384560.4 RNA Sequence

  2. XR_384561.4 RNA Sequence

  3. XR_384563.4 RNA Sequence

  4. XR_384562.4 RNA Sequence