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Klhl6 kelch-like 6 [ Mus musculus (house mouse) ]

Gene ID: 239743, updated on 12-May-2024

Summary

Official Symbol
Klhl6provided by MGI
Official Full Name
kelch-like 6provided by MGI
Primary source
MGI:MGI:2686922
See related
Ensembl:ENSMUSG00000043008 AllianceGenome:MGI:2686922
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Involved in B cell receptor signaling pathway and germinal center formation. Acts upstream of or within response to bacterium. Is expressed in blood vessel; notochord; and thymus primordium. Orthologous to human KLHL6 (kelch like family member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 18.2), spleen adult (RPKM 14.8) and 17 other tissues See more
Orthologs
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Genomic context

See Klhl6 in Genome Data Viewer
Location:
16 A3; 16 12.32 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (19765242..19801766, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (19946492..19983049, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40305 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 Neighboring gene STARR-seq mESC enhancer starr_40307 Neighboring gene RIKEN cDNA A930003A15 gene Neighboring gene STARR-seq mESC enhancer starr_40308 Neighboring gene STARR-seq mESC enhancer starr_40309 Neighboring gene STARR-positive B cell enhancer ABC_E2456 Neighboring gene STARR-positive B cell enhancer ABC_E1183 Neighboring gene kelch-like 24 Neighboring gene YEATS domain containing 2 Neighboring gene SMT3 suppressor of mif two 3 homolog 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (9) 
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417212.1NP_001404141.1  kelch-like protein 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC165282
  2. NM_001417213.1NP_001404142.1  kelch-like protein 6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC165282
  3. NM_001417214.1NP_001404143.1  kelch-like protein 6 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC165282
  4. NM_001417215.1NP_001404144.1  kelch-like protein 6 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC165282
  5. NM_001417216.1NP_001404145.1  kelch-like protein 6 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC165282
  6. NM_183390.4NP_899246.2  kelch-like protein 6 isoform 1

    See identical proteins and their annotated locations for NP_899246.2

    Status: VALIDATED

    Source sequence(s)
    AC165282
    Consensus CDS
    CCDS28041.2
    UniProtKB/Swiss-Prot
    Q497G3, Q6V595
    Related
    ENSMUSP00000053023.9, ENSMUST00000058839.10
    Conserved Domains (6) summary
    smart00612
    Location:420466
    Kelch; Kelch domain
    smart00225
    Location:71163
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00038
    Location:368405
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:60163
    BTB; BTB/POZ domain
    pfam01344
    Location:457501
    Kelch_1; Kelch motif
    pfam07707
    Location:172274
    BACK; BTB And C-terminal Kelch

RNA

  1. NR_184432.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC165282

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    19765242..19801766 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159920.1XP_036015813.1  kelch-like protein 6 isoform X2

    Conserved Domains (5) summary
    PHA03098
    Location:11487
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:292329
    Kelch; KELCH repeat [structural motif]
    cl38908
    Location:2098
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam01344
    Location:470507
    Kelch_1; Kelch motif
    cl28903
    Location:91198
    BACK; BACK (BTB and C-terminal Kelch) domain