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Lamp3 lysosomal-associated membrane protein 3 [ Mus musculus (house mouse) ]

Gene ID: 239739, updated on 18-Jun-2024

Summary

Official Symbol
Lamp3provided by MGI
Official Full Name
lysosomal-associated membrane protein 3provided by MGI
Primary source
MGI:MGI:2441659
See related
Ensembl:ENSMUSG00000041247 AllianceGenome:MGI:2441659
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LAMP; Cd208; DCLAMP; TSC403; DC-LAMP; 1200002D17Rik
Summary
Predicted to be involved in several processes, including negative regulation of proteolysis; regulation of viral life cycle; and response to interferon-alpha. Predicted to act upstream of or within adaptive immune response. Located in alveolar lamellar body membrane and lysosomal membrane. Is expressed in lung. Orthologous to human LAMP3 (lysosomal associated membrane protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward lung adult (RPKM 35.6) See more
Orthologs
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Genomic context

See Lamp3 in Genome Data Viewer
Location:
16 A3; 16 12.17 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (19472131..19525115, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (19653381..19706365, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily AJ member 5 Neighboring gene olfactory receptor family 2 subfamily AJ member 6 Neighboring gene STARR-seq mESC enhancer starr_40303 Neighboring gene STARR-seq mESC enhancer starr_40304 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_40305 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in alveolar lamellar body membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in alveolar lamellar body membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
lysosome-associated membrane glycoprotein 3
Names
DC LAMP
DC-lysosome-associated membrane glycoprotein
LAMP-3
dendritic cells-lysosome associated membrane glycoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177356.3NP_796330.2  lysosome-associated membrane glycoprotein 3 precursor

    See identical proteins and their annotated locations for NP_796330.2

    Status: VALIDATED

    Source sequence(s)
    AK028039, AK033379, BY067461, BY388271
    Consensus CDS
    CCDS37285.1
    UniProtKB/Swiss-Prot
    Q7TST5, Q8C1F6
    Related
    ENSMUSP00000080556.6, ENSMUST00000081880.7
    Conserved Domains (1) summary
    pfam01299
    Location:95411
    Lamp; Lysosome-associated membrane glycoprotein (Lamp)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    19472131..19525115 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)