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Mrtfb myocardin related transcription factor B [ Mus musculus (house mouse) ]

Gene ID: 239719, updated on 9-Oct-2021

Summary

Official Symbol
Mrtfbprovided by MGI
Official Full Name
myocardin related transcription factor Bprovided by MGI
Primary source
MGI:MGI:3050795
See related
Ensembl:ENSMUSG00000009569
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mkl; Mkl2; Mrtf; Gt4-1; MRTF-; MRTF-B; SOLOIST; mKIAA1243
Expression
Ubiquitous expression in frontal lobe adult (RPKM 9.3), cortex adult (RPKM 9.3) and 28 other tissues See more
Orthologs
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Genomic context

See Mrtfb in Genome Data Viewer
Location:
16; 16 A1
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (13073913..13235393)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (13256056..13417529)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (13256574..13417622)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene excision repair cross-complementing rodent repair deficiency, complementation group 4 Neighboring gene predicted gene, 32596 Neighboring gene uncharacterized LOC115488652 Neighboring gene predicted gene 15738 Neighboring gene nuclear encoded tRNA threonine 5 (anticodon CGT) Neighboring gene predicted gene, 41421 Neighboring gene predicted gene 53058 Neighboring gene predicted gene, 32817 Neighboring gene microRNA 193b

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1243, MGC41582

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables actin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within embryonic organ development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within forebrain development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within liver development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within muscle organ development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neuron migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuron projection development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of pri-miRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of striated muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in smooth muscle cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within smooth muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
myocardin-related transcription factor B
Names
MKL/myocardin-like 2
MKL/myocardin-like protein 2
gene trap insertion site 4-1
megakaryoblastic leukemia 2
megakaryoblastic leukemia 2 isoform named SOLOIST
myocardial related transcription factor B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122667.2NP_001116139.1  myocardin-related transcription factor B isoform 3

    See identical proteins and their annotated locations for NP_001116139.1

    Status: VALIDATED

    Source sequence(s)
    AC160961, AC163640
    Consensus CDS
    CCDS49768.1
    UniProtKB/TrEMBL
    G3X8R8
    Related
    ENSMUSP00000009713.8, ENSMUST00000009713.14
    Conserved Domains (5) summary
    PHA03247
    Location:197321
    PHA03247; large tegument protein UL36; Provisional
    pfam02037
    Location:394427
    SAP; SAP domain
    pfam02755
    Location:141163
    RPEL; RPEL repeat
    cl20817
    Location:565605
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl29414
    Location:5276
    RPEL; RPEL repeat
  2. NM_153588.3NP_705816.2  myocardin-related transcription factor B isoform 1

    See identical proteins and their annotated locations for NP_705816.2

    Status: VALIDATED

    Source sequence(s)
    AC163640, AF532598, CJ126058, CK639342
    Consensus CDS
    CCDS37258.1
    UniProtKB/Swiss-Prot
    P59759
    UniProtKB/TrEMBL
    Q5DTZ3
    Related
    ENSMUSP00000122815.2, ENSMUST00000149359.2
    Conserved Domains (4) summary
    smart00707
    Location:128153
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02037
    Location:383416
    SAP; SAP domain
    pfam02755
    Location:86107
    RPEL; RPEL repeat
    pfam09903
    Location:551588
    DUF2130; Uncharacterized protein conserved in bacteria (DUF2130)
  3. NM_181860.1NP_862908.1  myocardin-related transcription factor B isoform 2

    See identical proteins and their annotated locations for NP_862908.1

    Status: VALIDATED

    Source sequence(s)
    BC028459
    Consensus CDS
    CCDS37257.1
    UniProtKB/TrEMBL
    Q8R2L3
    Related
    ENSMUSP00000054993.7, ENSMUST00000056715.7

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    13073913..13235393
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522109.5XP_006522172.1  myocardin-related transcription factor B isoform X1

    See identical proteins and their annotated locations for XP_006522172.1

    Conserved Domains (5) summary
    PHA03247
    Location:218342
    PHA03247; large tegument protein UL36; Provisional
    pfam02037
    Location:415448
    SAP; SAP domain
    pfam02755
    Location:162184
    RPEL; RPEL repeat
    cl20817
    Location:586626
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl29414
    Location:7397
    RPEL; RPEL repeat
  2. XM_030249105.2XP_030104965.1  myocardin-related transcription factor B isoform X2

    Conserved Domains (5) summary
    PHA03247
    Location:197321
    PHA03247; large tegument protein UL36; Provisional
    pfam02037
    Location:394427
    SAP; SAP domain
    pfam02755
    Location:141163
    RPEL; RPEL repeat
    cl20817
    Location:565605
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl29414
    Location:5276
    RPEL; RPEL repeat
  3. XM_006522108.4XP_006522171.1  myocardin-related transcription factor B isoform X1

    See identical proteins and their annotated locations for XP_006522171.1

    Conserved Domains (5) summary
    PHA03247
    Location:218342
    PHA03247; large tegument protein UL36; Provisional
    pfam02037
    Location:415448
    SAP; SAP domain
    pfam02755
    Location:162184
    RPEL; RPEL repeat
    cl20817
    Location:586626
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl29414
    Location:7397
    RPEL; RPEL repeat
  4. XM_006522111.3XP_006522174.1  myocardin-related transcription factor B isoform X3

    See identical proteins and their annotated locations for XP_006522174.1

    UniProtKB/TrEMBL
    Q8R2L3
    Related
    ENSMUSP00000111476.2, ENSMUST00000115809.8
  5. XM_030249106.2XP_030104966.1  myocardin-related transcription factor B isoform X2

    Conserved Domains (5) summary
    PHA03247
    Location:197321
    PHA03247; large tegument protein UL36; Provisional
    pfam02037
    Location:394427
    SAP; SAP domain
    pfam02755
    Location:141163
    RPEL; RPEL repeat
    cl20817
    Location:565605
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl29414
    Location:5276
    RPEL; RPEL repeat
  6. XM_036159917.1XP_036015810.1  myocardin-related transcription factor B isoform X1

    Conserved Domains (5) summary
    PHA03247
    Location:218342
    PHA03247; large tegument protein UL36; Provisional
    pfam02037
    Location:415448
    SAP; SAP domain
    pfam02755
    Location:162184
    RPEL; RPEL repeat
    cl20817
    Location:586626
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl29414
    Location:7397
    RPEL; RPEL repeat
  7. XM_030249104.2XP_030104964.1  myocardin-related transcription factor B isoform X1

    Conserved Domains (5) summary
    PHA03247
    Location:218342
    PHA03247; large tegument protein UL36; Provisional
    pfam02037
    Location:415448
    SAP; SAP domain
    pfam02755
    Location:162184
    RPEL; RPEL repeat
    cl20817
    Location:586626
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl29414
    Location:7397
    RPEL; RPEL repeat
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