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Dip2b disco interacting protein 2 homolog B [ Mus musculus (house mouse) ]

Gene ID: 239667, updated on 8-May-2024

Summary

Official Symbol
Dip2bprovided by MGI
Official Full Name
disco interacting protein 2 homolog Bprovided by MGI
Primary source
MGI:MGI:2145977
See related
Ensembl:ENSMUSG00000023026 AllianceGenome:MGI:2145977
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1463; 4932422C22
Summary
Enables alpha-tubulin binding activity. Involved in negative regulation of axon extension and positive regulation of peptidyl-lysine acetylation. Located in axon; dendrite; and perikaryon. Is expressed in several structures, including central nervous system; liver; retina; spleen; and stomach. Orthologous to human DIP2B (disco interacting protein 2 homolog B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 10.4), whole brain E14.5 (RPKM 8.6) and 28 other tissues See more
Orthologs
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Genomic context

See Dip2b in Genome Data Viewer
Location:
15 F1; 15 56.14 cM
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (99935119..100117355)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (100037626..100219474)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 186, member A Neighboring gene predicted gene, 21917 Neighboring gene RIKEN cDNA 2310068J16 gene Neighboring gene STARR-positive B cell enhancer ABC_E3157 Neighboring gene La ribonucleoprotein 4 Neighboring gene STARR-seq mESC enhancer starr_39735 Neighboring gene STARR-positive B cell enhancer mm9_chr15:99890852-99891153 Neighboring gene STARR-seq mESC enhancer starr_39737 Neighboring gene STARR-seq mESC enhancer starr_39738 Neighboring gene STARR-seq mESC enhancer starr_39739 Neighboring gene STARR-seq mESC enhancer starr_39742 Neighboring gene STARR-seq mESC enhancer starr_39744 Neighboring gene STARR-seq mESC enhancer starr_39745 Neighboring gene activating transcription factor 1 Neighboring gene STARR-seq mESC enhancer starr_39746 Neighboring gene STARR-seq mESC enhancer starr_39747 Neighboring gene transmembrane (C-terminal) protease, serine 12

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA1463

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
disco-interacting protein 2 homolog B
Names
DIP2 disco-interacting protein 2 homolog B
DIP2 homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159361.3NP_001152833.1  disco-interacting protein 2 homolog B isoform 1

    See identical proteins and their annotated locations for NP_001152833.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC124479, AC125526, AC133868
    Consensus CDS
    CCDS49731.1
    UniProtKB/Swiss-Prot
    Q3UH60, Q8C1W5, Q8CDG9, Q8CHA2
    Related
    ENSMUSP00000097777.4, ENSMUST00000100203.10
    Conserved Domains (4) summary
    COG0318
    Location:334910
    CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
    pfam00501
    Location:9931468
    AMP-binding; AMP-binding enzyme
    pfam06464
    Location:14130
    DMAP_binding; DMAP1-binding Domain
    cl17068
    Location:358922
    AFD_class_I; Adenylate forming domain, Class I superfamily
  2. NM_001402901.1NP_001389830.1  disco-interacting protein 2 homolog B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC124479, AC125526, AC133868
  3. NM_172819.4NP_766407.2  disco-interacting protein 2 homolog B isoform 2

    See identical proteins and their annotated locations for NP_766407.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences causes translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC124479, AC125526
    Consensus CDS
    CCDS27831.1
    UniProtKB/TrEMBL
    B2RQC7, D3Z5G8
    Related
    ENSMUSP00000023768.8, ENSMUST00000023768.14
    Conserved Domains (3) summary
    COG0318
    Location:100676
    CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
    pfam00501
    Location:7591234
    AMP-binding; AMP-binding enzyme
    cl17068
    Location:124688
    AFD_class_I; Adenylate forming domain, Class I superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    99935119..100117355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245629.4XP_011243931.1  disco-interacting protein 2 homolog B isoform X1

    Conserved Domains (2) summary
    cd05905
    Location:10501615
    Dip2; Disco-interacting protein 2 (Dip2)
    pfam06464
    Location:14130
    DMAP_binding; DMAP1-binding Domain
  2. XM_011245630.4XP_011243932.1  disco-interacting protein 2 homolog B isoform X2

    Conserved Domains (2) summary
    cd05905
    Location:10491614
    Dip2; Disco-interacting protein 2 (Dip2)
    pfam06464
    Location:14130
    DMAP_binding; DMAP1-binding Domain
  3. XM_011245631.4XP_011243933.1  disco-interacting protein 2 homolog B isoform X4

    Conserved Domains (2) summary
    cd05905
    Location:9791544
    Dip2; Disco-interacting protein 2 (Dip2)
    pfam06464
    Location:14130
    DMAP_binding; DMAP1-binding Domain
  4. XM_011245632.4XP_011243934.1  disco-interacting protein 2 homolog B isoform X5

    Conserved Domains (2) summary
    cd05905
    Location:9781543
    Dip2; Disco-interacting protein 2 (Dip2)
    pfam06464
    Location:14130
    DMAP_binding; DMAP1-binding Domain