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Tenm4 teneurin transmembrane protein 4 [ Mus musculus (house mouse) ]

Gene ID: 23966, updated on 5-Apr-2024

Summary

Official Symbol
Tenm4provided by MGI
Official Full Name
teneurin transmembrane protein 4provided by MGI
Primary source
MGI:MGI:2447063
See related
Ensembl:ENSMUSG00000048078 AllianceGenome:MGI:2447063
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Doc4; ELM2; Odz4; l7Rn3; Ten-m4; l(7)-3Rn; mKIAA1302
Summary
Enables protein homodimerization activity. Involved in central nervous system myelin formation; positive regulation of gastrulation; and regulation of nervous system development. Acts upstream of or within cardiac cell fate specification; cardiac muscle cell proliferation; and gastrulation with mouth forming second. Located in cytoplasm; neuron projection; and nucleus. Is integral component of plasma membrane. Is expressed in several structures, including branchial arch; central nervous system; forelimb bud; future brain; and somite. Human ortholog(s) of this gene implicated in essential tremor 5. Orthologous to human TENM4 (teneurin transmembrane protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary adult (RPKM 25.2), subcutaneous fat pad adult (RPKM 11.8) and 10 other tissues See more
Orthologs
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Genomic context

See Tenm4 in Genome Data Viewer
Location:
7 E1; 7 52.53 cM
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (95550262..96560300)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (96171244..96911093)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57510 Neighboring gene STARR-seq mESC enhancer starr_19553 Neighboring gene predicted gene, 39049 Neighboring gene STARR-seq mESC enhancer starr_19555 Neighboring gene frataxin pseudogene Neighboring gene STARR-seq mESC enhancer starr_19557 Neighboring gene STARR-seq mESC enhancer starr_19558 Neighboring gene STARR-seq mESC enhancer starr_19562 Neighboring gene STARR-seq mESC enhancer starr_19563 Neighboring gene STARR-seq mESC enhancer starr_19564 Neighboring gene STARR-seq mESC enhancer starr_19567 Neighboring gene predicted gene 8319 Neighboring gene STARR-seq mESC enhancer starr_19570 Neighboring gene microRNA 708 Neighboring gene microRNA 6394 Neighboring gene predicted gene 15412 Neighboring gene STARR-seq mESC enhancer starr_19572 Neighboring gene ribosomal protein S11, pseudogene 5 Neighboring gene VISTA enhancer mm2003 Neighboring gene STARR-seq mESC enhancer starr_19576 Neighboring gene STARR-seq mESC enhancer starr_19579 Neighboring gene STARR-seq mESC enhancer starr_19580 Neighboring gene predicted gene 15413 Neighboring gene STARR-seq mESC enhancer starr_19583 Neighboring gene STARR-positive B cell enhancer mm9_chr7:104099810-104100111 Neighboring gene STARR-positive B cell enhancer mm9_chr7:104119017-104119317 Neighboring gene STARR-seq mESC enhancer starr_19585 Neighboring gene predicted gene, 22226 Neighboring gene asparaginyl-tRNA synthetase 2 (mitochondrial)(putative)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
lethal, Chr 7, Rinchik 3
GeneReviews: Not available

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cardiac cell fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in central nervous system myelin formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in central nervous system myelin formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within gastrulation with mouth forming second IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neuron development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gastrulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of myelination ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
teneurin-4
Names
downstream of CHOP4
odd Oz/ten-m homolog 4
protein Odd Oz/ten-m homolog 4
ten-4
tenascin-M4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310760.1NP_001297689.1  teneurin-4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC073599, AC162370, AK147579, BE980985
    Consensus CDS
    CCDS80753.1
    UniProtKB/Swiss-Prot
    Q3UHK6
    Related
    ENSMUSP00000102783.2, ENSMUST00000107165.8
    Conserved Domains (8) summary
    COG3209
    Location:16662362
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:12961335
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:24462525
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:12861627
    NHL; NHL repeat unit of beta-propeller proteins
    pfam01414
    Location:808850
    DSL; Delta serrate ligand
    pfam01500
    Location:691839
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam06484
    Location:36402
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:27492826
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
  2. NM_001310762.1NP_001297691.1  teneurin-4 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, uses a downstream start codon, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AC073599, AC116683, AC158136, AC162370, AK147579, BE980985
    Consensus CDS
    CCDS80754.1
    UniProtKB/Swiss-Prot
    Q3UHK6
    Related
    ENSMUSP00000102780.2, ENSMUST00000107162.8
    Conserved Domains (10) summary
    COG3209
    Location:17382494
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:13331382
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:17321772
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:24382517
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:699847
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam06484
    Location:11410
    Ten_N; Teneurin Intracellular Region
    pfam07974
    Location:703729
    EGF_2; EGF-like domain
    pfam15636
    Location:27432818
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:12851619
    NHL; NHL repeat unit of beta-propeller proteins
    cl19567
    Location:817858
    DSL; Delta serrate ligand
  3. NM_011858.4NP_035988.2  teneurin-4 isoform 2

    See identical proteins and their annotated locations for NP_035988.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC162370, AK147329, BE980985
    Consensus CDS
    CCDS40024.1
    UniProtKB/Swiss-Prot
    Q3UHK6
    Related
    ENSMUSP00000102784.2, ENSMUST00000107166.8
    Conserved Domains (8) summary
    COG3209
    Location:16292325
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:12591298
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:24092488
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:12491590
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:36365
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:27122789
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:593728
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:772813
    DSL; Delta serrate ligand

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    95550262..96560300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153061.1XP_036008954.1  teneurin-4 isoform X10

    Conserved Domains (8) summary
    COG3209
    Location:16992395
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:13291368
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:24792558
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:13191660
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:36435
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:27822859
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:663798
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:842883
    DSL; Delta serrate ligand
  2. XM_006507806.4XP_006507869.1  teneurin-4 isoform X10

    See identical proteins and their annotated locations for XP_006507869.1

    Conserved Domains (8) summary
    COG3209
    Location:16992395
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:13291368
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:24792558
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:13191660
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:36435
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:27822859
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:663798
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:842883
    DSL; Delta serrate ligand
  3. XM_030242548.1XP_030098408.1  teneurin-4 isoform X14

    Conserved Domains (8) summary
    COG3209
    Location:16292325
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:12591298
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:24092488
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:12491590
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:36365
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:27122789
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:593728
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:772813
    DSL; Delta serrate ligand
  4. XM_036153067.1XP_036008960.1  teneurin-4 isoform X16

    Conserved Domains (8) summary
    COG3209
    Location:15962292
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:12261265
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:23762455
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:12161557
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:36332
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:26792756
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:560695
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:739780
    DSL; Delta serrate ligand
  5. XM_036153070.1XP_036008963.1  teneurin-4 isoform X17

    Conserved Domains (7) summary
    COG3209
    Location:15872283
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:12171256
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:23672446
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:12071548
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:36332
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:26702747
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:560821
    exchanger_TraA; outer membrane exchange protein TraA
  6. XM_006507804.2XP_006507867.1  teneurin-4 isoform X10

    See identical proteins and their annotated locations for XP_006507867.1

    Conserved Domains (8) summary
    COG3209
    Location:16992395
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:13291368
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:24792558
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:13191660
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:36435
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:27822859
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:663798
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:842883
    DSL; Delta serrate ligand
  7. XM_030242546.1XP_030098406.1  teneurin-4 isoform X13

    Conserved Domains (8) summary
    COG3209
    Location:16662362
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:12961335
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:24462525
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:12861627
    NHL; NHL repeat unit of beta-propeller proteins
    pfam01414
    Location:808850
    DSL; Delta serrate ligand
    pfam01500
    Location:691839
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam06484
    Location:36402
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:27492826
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
  8. XM_030242544.1XP_030098404.1  teneurin-4 isoform X11

    Conserved Domains (8) summary
    COG3209
    Location:16742370
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:13041343
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:24542533
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:12941635
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:11410
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:27572834
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:638773
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:817858
    DSL; Delta serrate ligand
  9. XM_030242550.1XP_030098410.1  teneurin-4 isoform X15

    UniProtKB/Swiss-Prot
    O70465, Q3TSI0, Q3UH52, Q3UHK6, Q80TF5, Q9WTS7
    Conserved Domains (8) summary
    COG3209
    Location:16042300
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:12341273
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:23842463
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:12241565
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:11340
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:26872764
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:568703
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:747788
    DSL; Delta serrate ligand
  10. XM_030242545.1XP_030098405.1  teneurin-4 isoform X11

    Conserved Domains (8) summary
    COG3209
    Location:16742370
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:13041343
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:24542533
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:12941635
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:11410
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:27572834
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:638773
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:817858
    DSL; Delta serrate ligand
  11. XM_030242551.1XP_030098411.1  teneurin-4 isoform X15

    UniProtKB/Swiss-Prot
    O70465, Q3TSI0, Q3UH52, Q3UHK6, Q80TF5, Q9WTS7
    Conserved Domains (8) summary
    COG3209
    Location:16042300
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:12341273
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:23842463
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:12241565
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:11340
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:26872764
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:568703
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:747788
    DSL; Delta serrate ligand
  12. XM_036153062.1XP_036008955.1  teneurin-4 isoform X11

    Conserved Domains (8) summary
    COG3209
    Location:16742370
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:13041343
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:24542533
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:12941635
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:11410
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:27572834
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:638773
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:817858
    DSL; Delta serrate ligand
  13. XM_036153066.1XP_036008959.1  teneurin-4 isoform X15

    UniProtKB/Swiss-Prot
    O70465, Q3TSI0, Q3UH52, Q3UHK6, Q80TF5, Q9WTS7
    Conserved Domains (8) summary
    COG3209
    Location:16042300
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:12341273
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:23842463
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:12241565
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:11340
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:26872764
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:568703
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:747788
    DSL; Delta serrate ligand
  14. XM_036153052.1XP_036008945.1  teneurin-4 isoform X1

    Conserved Domains (8) summary
    COG3209
    Location:18172513
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:14471486
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:25972676
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:14371778
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:154553
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:29002977
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:781916
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:9601001
    DSL; Delta serrate ligand
  15. XM_036153053.1XP_036008946.1  teneurin-4 isoform X2

    Conserved Domains (8) summary
    COG3209
    Location:18102506
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:14471475
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:25902669
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:14371771
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:154553
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:28932970
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:781916
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:9601001
    DSL; Delta serrate ligand
  16. XM_036153054.1XP_036008947.1  teneurin-4 isoform X3

    Conserved Domains (7) summary
    COG3209
    Location:18082504
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:14381477
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:25882667
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:14281769
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:154553
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:28912968
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:7811042
    exchanger_TraA; outer membrane exchange protein TraA
  17. XM_036153055.1XP_036008948.1  teneurin-4 isoform X4

    Conserved Domains (7) summary
    COG3209
    Location:18012497
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:14381466
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:25812660
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:14281762
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:154553
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:28842961
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:7811042
    exchanger_TraA; outer membrane exchange protein TraA
  18. XM_036153056.1XP_036008949.1  teneurin-4 isoform X5

    Conserved Domains (8) summary
    COG3209
    Location:17842480
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:14141453
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:25642643
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:14041745
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:154520
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:28672944
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:748883
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:927968
    DSL; Delta serrate ligand
  19. XM_036153072.1XP_036008965.1  teneurin-4 isoform X21

    Conserved Domains (8) summary
    COG3209
    Location:17772473
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:14141442
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:25572636
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:14041738
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:154520
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:28602937
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:748883
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:927968
    DSL; Delta serrate ligand
  20. XM_036153057.1XP_036008950.1  teneurin-4 isoform X6

    Conserved Domains (7) summary
    COG3209
    Location:17752471
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:14051444
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:25552634
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:13951736
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:154520
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:28582935
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:7481009
    exchanger_TraA; outer membrane exchange protein TraA
  21. XM_036153058.1XP_036008951.1  teneurin-4 isoform X7

    Conserved Domains (8) summary
    COG3209
    Location:17472443
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:13771416
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:25272606
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:13671708
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:154483
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:28302907
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:711846
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:890931
    DSL; Delta serrate ligand
  22. XM_036153059.1XP_036008952.1  teneurin-4 isoform X9

    Conserved Domains (8) summary
    COG3209
    Location:17142410
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:13441383
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:24942573
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:13341675
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:154450
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:27972874
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:678813
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:857898
    DSL; Delta serrate ligand
  23. XM_030242552.1XP_030098412.1  teneurin-4 isoform X18

    Conserved Domains (8) summary
    COG3209
    Location:15712267
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:12011240
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:23512430
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:11911532
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:11307
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:26542731
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:535670
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:714755
    DSL; Delta serrate ligand
  24. XM_006507805.3XP_006507868.1  teneurin-4 isoform X10

    See identical proteins and their annotated locations for XP_006507868.1

    Conserved Domains (8) summary
    COG3209
    Location:16992395
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:13291368
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:24792558
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:13191660
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:36435
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:27822859
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:663798
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:842883
    DSL; Delta serrate ligand
  25. XM_030242549.2XP_030098409.1  teneurin-4 isoform X14

    Conserved Domains (8) summary
    COG3209
    Location:16292325
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:12591298
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:24092488
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:12491590
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:36365
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:27122789
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:593728
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:772813
    DSL; Delta serrate ligand
  26. XM_036153060.1XP_036008953.1  teneurin-4 isoform X10

    Conserved Domains (8) summary
    COG3209
    Location:16992395
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:13291368
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:24792558
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:13191660
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:36435
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:27822859
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:663798
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:842883
    DSL; Delta serrate ligand
  27. XM_036153069.1XP_036008962.1  teneurin-4 isoform X16

    Conserved Domains (8) summary
    COG3209
    Location:15962292
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:12261265
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:23762455
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:12161557
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:36332
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:26792756
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:560695
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:739780
    DSL; Delta serrate ligand
  28. XM_006507807.5XP_006507870.1  teneurin-4 isoform X11

    See identical proteins and their annotated locations for XP_006507870.1

    Conserved Domains (8) summary
    COG3209
    Location:16742370
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:13041343
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:24542533
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:12941635
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:11410
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:27572834
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:638773
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:817858
    DSL; Delta serrate ligand
  29. XM_036153065.1XP_036008958.1  teneurin-4 isoform X15

    UniProtKB/Swiss-Prot
    O70465, Q3TSI0, Q3UH52, Q3UHK6, Q80TF5, Q9WTS7
    Conserved Domains (8) summary
    COG3209
    Location:16042300
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:12341273
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:23842463
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:12241565
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:11340
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:26872764
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:568703
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:747788
    DSL; Delta serrate ligand
  30. XM_036153071.1XP_036008964.1  teneurin-4 isoform X18

    Conserved Domains (8) summary
    COG3209
    Location:15712267
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:12011240
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:23512430
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:11911532
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:11307
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:26542731
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:535670
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:714755
    DSL; Delta serrate ligand
  31. XM_006507803.5XP_006507866.1  teneurin-4 isoform X10

    See identical proteins and their annotated locations for XP_006507866.1

    Conserved Domains (8) summary
    COG3209
    Location:16992395
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:13291368
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:24792558
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:13191660
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:36435
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:27822859
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:663798
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:842883
    DSL; Delta serrate ligand
  32. XM_036153064.1XP_036008957.1  teneurin-4 isoform X14

    Conserved Domains (8) summary
    COG3209
    Location:16292325
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:12591298
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:24092488
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:12491590
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:36365
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:27122789
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:593728
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:772813
    DSL; Delta serrate ligand
  33. XM_036153068.1XP_036008961.1  teneurin-4 isoform X16

    Conserved Domains (8) summary
    COG3209
    Location:15962292
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:12261265
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:23762455
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:12161557
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:36332
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:26792756
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:560695
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:739780
    DSL; Delta serrate ligand
  34. XM_006507808.5XP_006507871.1  teneurin-4 isoform X11

    See identical proteins and their annotated locations for XP_006507871.1

    Conserved Domains (8) summary
    COG3209
    Location:16742370
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:13041343
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:24542533
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:12941635
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:11410
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:27572834
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:638773
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:817858
    DSL; Delta serrate ligand
  35. XM_006507801.5XP_006507864.1  teneurin-4 isoform X8

    Conserved Domains (8) summary
    COG3209
    Location:17402436
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:13701409
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:25202599
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:13601701
    NHL; NHL repeat unit of beta-propeller proteins
    pfam01414
    Location:882924
    DSL; Delta serrate ligand
    pfam01500
    Location:765913
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam06484
    Location:77476
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:28232900
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
  36. XM_036153063.1XP_036008956.1  teneurin-4 isoform X12

    Conserved Domains (8) summary
    COG3209
    Location:16702366
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:13001339
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:24502529
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:12901631
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:77406
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:27532830
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:634769
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:813854
    DSL; Delta serrate ligand
  37. XM_011241793.1XP_011240095.1  teneurin-4 isoform X11

    See identical proteins and their annotated locations for XP_011240095.1

    Conserved Domains (8) summary
    COG3209
    Location:16742370
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:13041343
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:24542533
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:12941635
    NHL; NHL repeat unit of beta-propeller proteins
    pfam06484
    Location:11410
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:27572834
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:638773
    exchanger_TraA; outer membrane exchange protein TraA
    cl19567
    Location:817858
    DSL; Delta serrate ligand
  38. XM_006507812.5XP_006507875.1  teneurin-4 isoform X19

    Conserved Domains (7) summary
    COG3209
    Location:8521548
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:5180
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:482521
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:16321711
    Rhs_assc_core; RHS repeat-associated core domain
    pfam07974
    Location:1036
    EGF_2; EGF-like domain
    cl18310
    Location:472813
    NHL; NHL repeat unit of beta-propeller proteins
    pfam15636
    Location:19352012
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
  39. XM_006507813.5XP_006507876.1  teneurin-4 isoform X20

    Conserved Domains (7) summary
    COG3209
    Location:8431539
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:4271
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:473512
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:16231702
    Rhs_assc_core; RHS repeat-associated core domain
    pfam07974
    Location:1036
    EGF_2; EGF-like domain
    cl18310
    Location:463804
    NHL; NHL repeat unit of beta-propeller proteins
    pfam15636
    Location:19262003
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin