Format

Send to:

Choose Destination

Cacna1i calcium channel, voltage-dependent, alpha 1I subunit [ Mus musculus (house mouse) ]

Gene ID: 239556, updated on 29-Oct-2019

Summary

Official Symbol
Cacna1iprovided by MGI
Official Full Name
calcium channel, voltage-dependent, alpha 1I subunitprovided by MGI
Primary source
MGI:MGI:2178051
See related
Ensembl:ENSMUSG00000022416
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ca(V)3.3
Expression
Biased expression in spleen adult (RPKM 8.3), frontal lobe adult (RPKM 8.1) and 8 other tissues See more
Orthologs

Genomic context

See Cacna1i in Genome Data Viewer
Location:
15; 15 E1
Exon count:
37
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (80287238..80398292)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (80117668..80228722)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein S19 binding protein 1 Neighboring gene activating transcription factor 4 Neighboring gene predicted gene, 31319 Neighboring gene predicted gene, 41363 Neighboring gene predicted gene, 31369 Neighboring gene ENTH domain containing 1 Neighboring gene predicted gene, 23220

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • Aldosterone synthesis and secretion, organism-specific biosystem (from KEGG)
    Aldosterone synthesis and secretion, organism-specific biosystemAldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa. Aldosterone plays an important role in the regulation of systemic blood ...
  • Aldosterone synthesis and secretion, conserved biosystem (from KEGG)
    Aldosterone synthesis and secretion, conserved biosystemAldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa. Aldosterone plays an important role in the regulation of systemic blood ...
  • Calcium signaling pathway, organism-specific biosystem (from KEGG)
    Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Calcium signaling pathway, conserved biosystem (from KEGG)
    Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Circadian entrainment, organism-specific biosystem (from KEGG)
    Circadian entrainment, organism-specific biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
  • Circadian entrainment, conserved biosystem (from KEGG)
    Circadian entrainment, conserved biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
low voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
low voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
voltage-gated sodium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
calcium ion import IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion import ISO
Inferred from Sequence Orthology
more info
 
calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
calcium ion transport into cytosol ISO
Inferred from Sequence Orthology
more info
 
membrane depolarization during action potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuronal action potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuronal action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of calcium ion-dependent exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
sleep IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
voltage-gated sodium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
voltage-dependent T-type calcium channel subunit alpha-1I
Names
low voltage-activated T-type calcium channel alpha-1 subunit (CACNA1I)
low-voltage-activated calcium channel alpha13.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044308.2NP_001037773.2  voltage-dependent T-type calcium channel subunit alpha-1I

    Status: VALIDATED

    Source sequence(s)
    AC155313, AK147585, CJ259561
    Consensus CDS
    CCDS49670.1
    UniProtKB/TrEMBL
    E9Q7P2
    Related
    ENSMUSP00000125063.1, ENSMUST00000160424.7
    Conserved Domains (1) summary
    pfam00520
    Location:615824
    Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000081.6 Reference GRCm38.p6 C57BL/6J

    Range
    80287238..80398292
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520949.2XP_006521012.1  voltage-dependent T-type calcium channel subunit alpha-1I isoform X1

    Conserved Domains (1) summary
    pfam00520
    Location:615824
    Ion_trans; Ion transport protein
  2. XM_030248558.1XP_030104418.1  voltage-dependent T-type calcium channel subunit alpha-1I isoform X3

    Related
    ENSMUSP00000125229.1, ENSMUST00000162155.7
  3. XM_006520950.2XP_006521013.1  voltage-dependent T-type calcium channel subunit alpha-1I isoform X2

    Conserved Domains (1) summary
    pfam00520
    Location:615824
    Ion_trans; Ion transport protein
Support Center