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Apol8 apolipoprotein L 8 [ Mus musculus (house mouse) ]

Gene ID: 239552, updated on 26-Sep-2022

Summary

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Official Symbol
Apol8provided by MGI
Official Full Name
apolipoprotein L 8provided by MGI
Primary source
MGI:MGI:2444921
See related
Ensembl:ENSMUSG00000056656 AllianceGenome:MGI:2444921
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Apol2; APOL-II; 9830006J20Rik
Summary
Predicted to enable chloride channel activity and lipid binding activity. Predicted to be located in extracellular space and intracellular membrane-bounded organelle. Predicted to be part of high-density lipoprotein particle and very-low-density lipoprotein particle. Is expressed in liver. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis and schizophrenia. Orthologous to human APOL1 (apolipoprotein L1); APOL3 (apolipoprotein L3); and APOL4 (apolipoprotein L4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14.5 (RPKM 24.1), liver E14 (RPKM 23.0) and 3 other tissues See more
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Genomic context

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See Apol8 in Genome Data Viewer
Location:
15; 15 E1
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (77629309..77641306, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (77745109..77757062, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene apolipoprotein L 7e Neighboring gene predicted gene, 36329 Neighboring gene apolipoprotein L 9b Neighboring gene myosin, heavy polypeptide 9, non-muscle Neighboring gene VISTA enhancer mm1644 Neighboring gene predicted gene, 22107

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chloride channel activity ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables lipid binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
part_of high-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
part_of very-low-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
apolipoprotein L2
Names
apolipoprotein L, 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081970.2 → NP_001075439.1  apolipoprotein L2

    See identical proteins and their annotated locations for NP_001075439.1

    Status: VALIDATED

    Source sequence(s)
    AL583886
    Consensus CDS
    CCDS56989.1
    UniProtKB/TrEMBL
    A2VDH7, F7B5U4
    Related
    ENSMUSP00000086873.5, ENSMUST00000089450.5
    Conserved Domains (1) summary
    pfam05461
    Location:29 → 333
    ApoL; Apolipoprotein L

  2. NM_001357895.1 → NP_001344824.1  apolipoprotein L2

    Status: VALIDATED

    Source sequence(s)
    AL583886
    Consensus CDS
    CCDS56989.1
    UniProtKB/TrEMBL
    F7B5U4
    Related
    ENSMUSP00000064237.3, ENSMUST00000070911.4
    Conserved Domains (1) summary
    pfam05461
    Location:29 → 333
    ApoL; Apolipoprotein L

  3. NM_001357896.1 → NP_001344825.1  apolipoprotein L2

    Status: VALIDATED

    Source sequence(s)
    AL583886
    Consensus CDS
    CCDS56989.1
    UniProtKB/TrEMBL
    F7B5U4
    Conserved Domains (1) summary
    pfam05461
    Location:29 → 333
    ApoL; Apolipoprotein L

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    77629309..77641306 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520939.5 → XP_006521002.1  apolipoprotein L2 isoform X1

    See identical proteins and their annotated locations for XP_006521002.1

    Conserved Domains (1) summary
    pfam05461
    Location:29 → 423
    ApoL; Apolipoprotein L

  2. XM_006520937.5 → XP_006521000.1  apolipoprotein L2 isoform X1

    See identical proteins and their annotated locations for XP_006521000.1

    Conserved Domains (1) summary
    pfam05461
    Location:29 → 423
    ApoL; Apolipoprotein L

  3. XM_030248554.2 → XP_030104414.1  apolipoprotein L2 isoform X3

    UniProtKB/TrEMBL
    F7B5U4
    Conserved Domains (1) summary
    pfam05461
    Location:29 → 333
    ApoL; Apolipoprotein L

  4. XM_006520934.5 → XP_006520997.3  apolipoprotein L2 isoform X2

    Conserved Domains (1) summary
    pfam05461
    Location:129 → 433
    ApoL; Apolipoprotein L

  5. XM_006520932.4 → XP_006520995.2  apolipoprotein L2 isoform X1

    Conserved Domains (1) summary
    pfam05461
    Location:29 → 423
    ApoL; Apolipoprotein L

  6. XM_030248553.1 → XP_030104413.1  apolipoprotein L2 isoform X1

    Conserved Domains (1) summary
    pfam05461
    Location:29 → 423
    ApoL; Apolipoprotein L

  7. XM_006520938.4 → XP_006521001.1  apolipoprotein L2 isoform X1

    See identical proteins and their annotated locations for XP_006521001.1

    Conserved Domains (1) summary
    pfam05461
    Location:29 → 423
    ApoL; Apolipoprotein L

  8. XM_006520936.4 → XP_006520999.1  apolipoprotein L2 isoform X1

    See identical proteins and their annotated locations for XP_006520999.1

    Conserved Domains (1) summary
    pfam05461
    Location:29 → 423
    ApoL; Apolipoprotein L

  9. XM_011245619.3 → XP_011243921.1  apolipoprotein L2 isoform X1

    See identical proteins and their annotated locations for XP_011243921.1

    Conserved Domains (1) summary
    pfam05461
    Location:29 → 423
    ApoL; Apolipoprotein L

RNA

  1. XR_003951390.1 RNA Sequence

  2. XR_003951389.1 RNA Sequence

  3. XR_003951388.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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