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Nek3 NIMA (never in mitosis gene a)-related expressed kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 23954, updated on 26-Sep-2022

Summary

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Official Symbol
Nek3provided by MGI
Official Full Name
NIMA (never in mitosis gene a)-related expressed kinase 3provided by MGI
Primary source
MGI:MGI:1344371
See related
Ensembl:ENSMUSG00000031478 AllianceGenome:MGI:1344371
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable ATP binding activity; metal ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including neuron projection morphogenesis; protein phosphorylation; and regulation of tubulin deacetylation. Predicted to be located in cell projection and cytoplasm. Is expressed in several structures, including brain; genitourinary system; intestine; and spleen. Orthologous to human NEK3 (NIMA related kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 2.5), CNS E11.5 (RPKM 2.4) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Nek3 in Genome Data Viewer
Location:
8 A2; 8 11.07 cM
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (22618299..22657009, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (22128283..22166997, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene asparagine-linked glycosylation 11 (alpha-1,2-mannosyltransferase) Neighboring gene NIMA (never in mitosis gene a)-related expressed kinase 5 Neighboring gene small nucleolar RNA U13 Neighboring gene cytoskeleton associated protein 2 Neighboring gene predicted gene, 29878

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The NIMA-family kinase Nek3 regulates microtubule acetylation in neurons. Chang J, et al. J Cell Sci, 2009 Jul 1. PMID 19509051, Free PMC Article
  2. Cloning and characterization of the murine Nek3 protein kinase, a novel member of the NIMA family of putative cell cycle regulators. Tanaka K, et al. J Biol Chem, 1999 May 7. PMID 10224116
  3. The murine orthologue of the Golgi-localized TPTE protein provides clues to the evolutionary history of the human TPTE gene family. Guipponi M, et al. Hum Genet, 2001 Dec. PMID 11810268
  4. NIMA-related kinases: isolation and characterization of murine nek3 and nek4 cDNAs, and chromosomal localization of nek1, nek2 and nek3. Chen A, et al. Gene, 1999 Jun 24. PMID 10393247
  5. Age-associated alteration of gene expression patterns in mouse oocytes. Hamatani T, et al. Hum Mol Genet, 2004 Oct 1. PMID 15317747

See all (10) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that Nek3 influences neuronal morphogenesis and polarity through effects on microtubules.
    Title: The NIMA-family kinase Nek3 regulates microtubule acetylation in neurons.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of tubulin deacetylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase Nek3
Names
NIMA-related expressed kinase 3
never in mitosis A-related kinase 3
nimA-related protein kinase 3
NP_001156419.1
NP_035978.2
XP_006509174.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162947.1 → NP_001156419.1  serine/threonine-protein kinase Nek3 isoform 1

    See identical proteins and their annotated locations for NP_001156419.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC117665
    Consensus CDS
    CCDS52519.1
    UniProtKB/Swiss-Prot
    Q9R0A5, Q9Z0X9
    Related
    ENSMUSP00000136876.2, ENSMUST00000178324.2
    Conserved Domains (1) summary
    cl21453
    Location:3 → 255
    PKc_like; Protein Kinases, catalytic domain

  2. NM_011848.4 → NP_035978.2  serine/threonine-protein kinase Nek3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. This results in a shorter isoform (2) compared to isoform 1.
    Source sequence(s)
    AC117665, BU058938, CV560683
    Consensus CDS
    CCDS22169.1
    UniProtKB/TrEMBL
    F8WGD4
    Related
    ENSMUSP00000033865.10, ENSMUST00000033865.16
    Conserved Domains (2) summary
    smart00220
    Location:4 → 250
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:3 → 255
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    22618299..22657009 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509111.5 → XP_006509174.1  serine/threonine-protein kinase Nek3 isoform X1

    See identical proteins and their annotated locations for XP_006509174.1

    UniProtKB/Swiss-Prot
    Q9R0A5, Q9Z0X9
    Related
    ENSMUSP00000106358.4, ENSMUST00000110730.10
    Conserved Domains (1) summary
    cl21453
    Location:3 → 255
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_378785.5 RNA Sequence

  2. XR_003947272.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R0A5.2 GenPept UniProtKB/Swiss-Prot:Q9R0A5

Gene LinkOut

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