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Slc30a8 solute carrier family 30 (zinc transporter), member 8 [ Mus musculus (house mouse) ]

Gene ID: 239436, updated on 27-Nov-2024

Summary

Official Symbol
Slc30a8provided by MGI
Official Full Name
solute carrier family 30 (zinc transporter), member 8provided by MGI
Primary source
MGI:MGI:2442682
See related
Ensembl:ENSMUSG00000022315 AllianceGenome:MGI:2442682
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ZnT8; ZnT-8; C820002P14Rik
Summary
Enables protein homodimerization activity and zinc ion transmembrane transporter activity. Involved in several processes, including insulin processing; insulin secretion; and intracellular zinc ion homeostasis. Located in cytoplasmic vesicle. Is active in secretory granule membrane. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human SLC30A8 (solute carrier family 30 member 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Slc30a8 in Genome Data Viewer
Location:
15 C; 15 19.88 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (52158949..52199194)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (52295553..52335798)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein 10; DNA segment, Chr X, human DXS648E; 24.6 kDa protein Neighboring gene predicted gene 7543 Neighboring gene STARR-seq mESC enhancer starr_38666 Neighboring gene predicted gene, 41321 Neighboring gene predicted gene, 41322

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (7)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables zinc ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion transmembrane transporter activity TAS
Traceable Author Statement
more info
 
enables zinc:proton antiporter activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc:proton antiporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
NOT involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in insulin processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in insulin secretion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular zinc ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular zinc ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
 
involved_in response to glucose IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to glucose IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to glucose ISO
Inferred from Sequence Orthology
more info
 
involved_in response to interleukin-1 IEA
Inferred from Electronic Annotation
more info
 
involved_in response to type II interferon IEA
Inferred from Electronic Annotation
more info
 
involved_in response to zinc ion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in zinc ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in zinc ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in zinc ion import into organelle ISO
Inferred from Sequence Orthology
more info
 
involved_in zinc ion import into organelle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in zinc ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in zinc ion transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in secretory granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 
is_active_in secretory granule membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule membrane ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
proton-coupled zinc antiporter SLC30A8
Names
zinc transporter 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172816.4NP_766404.1  proton-coupled zinc antiporter SLC30A8

    See identical proteins and their annotated locations for NP_766404.1

    Status: VALIDATED

    Source sequence(s)
    AC127562
    Consensus CDS
    CCDS27464.1
    UniProtKB/Swiss-Prot
    Q8BGG0
    Related
    ENSMUSP00000035257.3, ENSMUST00000037240.3
    Conserved Domains (2) summary
    TIGR01297
    Location:82352
    CDF; cation diffusion facilitator family transporter
    pfam01545
    Location:82273
    Cation_efflux; Cation efflux family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    52158949..52199194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)