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Esyt1 extended synaptotagmin-like protein 1 [ Mus musculus (house mouse) ]

Gene ID: 23943, updated on 1-Mar-2024

Summary

Official Symbol
Esyt1provided by MGI
Official Full Name
extended synaptotagmin-like protein 1provided by MGI
Primary source
MGI:MGI:1344426
See related
Ensembl:ENSMUSG00000025366 AllianceGenome:MGI:1344426
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mbc2; vp115; Fam62a
Summary
Predicted to enable calcium ion binding activity; identical protein binding activity; and phospholipid binding activity. Predicted to be involved in endoplasmic reticulum-plasma membrane tethering and lipid transport. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of endoplasmic reticulum membrane. Predicted to be extrinsic component of cytoplasmic side of plasma membrane and intrinsic component of endoplasmic reticulum membrane. Is expressed in several structures, including foregut; genitourinary system; nervous system; sensory organ; and spleen. Orthologous to human ESYT1 (extended synaptotagmin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in mammary gland adult (RPKM 71.2), subcutaneous fat pad adult (RPKM 68.6) and 25 other tissues See more
Orthologs
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Genomic context

See Esyt1 in Genome Data Viewer
Location:
10 D3; 10 76.85 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128346117..128361728, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128510248..128525859, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene Riken cDNA A430046D13 gene Neighboring gene STARR-positive B cell enhancer ABC_E8378 Neighboring gene myosin, light polypeptide 6B Neighboring gene microRNA 6916 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127962008-127962317 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127962362-127962471 Neighboring gene STARR-positive B cell enhancer ABC_E90 Neighboring gene STARR-positive B cell enhancer ABC_E3927 Neighboring gene STARR-positive B cell enhancer ABC_E8870 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127984844-127985032 Neighboring gene zinc finger CCCH type containing 10 Neighboring gene STARR-positive B cell enhancer ABC_E2973 Neighboring gene ribosomal protein L41

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (8)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylcholine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylethanolamine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phospholipid transfer activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in endoplasmic reticulum-plasma membrane tethering IEA
Inferred from Electronic Annotation
more info
 
involved_in intermembrane lipid transfer ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
extended synaptotagmin-1
Names
E-Syt1
family with sequence similarity 62 (C2 domain containing), member A
membrane-bound C2 domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011843.2NP_035973.1  extended synaptotagmin-1

    See identical proteins and their annotated locations for NP_035973.1

    Status: PROVISIONAL

    Source sequence(s)
    AC170752
    Consensus CDS
    CCDS24280.1
    UniProtKB/Swiss-Prot
    Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6
    Related
    ENSMUSP00000026427.7, ENSMUST00000026427.8
    Conserved Domains (4) summary
    cd04030
    Location:9591084
    C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
    cd04050
    Location:469573
    C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
    cd08391
    Location:635753
    C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
    pfam17047
    Location:125303
    SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    128346117..128361728 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)