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Rspo2 R-spondin 2 [ Mus musculus (house mouse) ]

Gene ID: 239405, updated on 8-Feb-2024

Summary

Official Symbol
Rspo2provided by MGI
Official Full Name
R-spondin 2provided by MGI
Primary source
MGI:MGI:1922667
See related
Ensembl:ENSMUSG00000051920 AllianceGenome:MGI:1922667
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ftls; D430027K22; 2610028F08Rik
Summary
Enables heparin binding activity. Acts upstream of or within several processes, including embryonic limb morphogenesis; negative regulation of odontogenesis of dentin-containing tooth; and respiratory system development. Located in cell surface and extracellular region. Is expressed in several structures, including brain; jaw; limb bud; pelvic urethra; and sensory organ. Human ortholog(s) of this gene implicated in tetraamelia syndrome 2. Orthologous to human RSPO2 (R-spondin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 3.5), CNS E18 (RPKM 1.5) and 8 other tissues See more
Orthologs
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Genomic context

See Rspo2 in Genome Data Viewer
Location:
15 B3.1; 15 16.73 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (42884184..43034990, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (43020788..43171594, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene angiopoietin 1 Neighboring gene predicted gene, 17473 Neighboring gene STARR-seq mESC enhancer starr_38545 Neighboring gene predicted gene, 46505 Neighboring gene STARR-seq mESC enhancer starr_38546 Neighboring gene STARR-seq mESC enhancer starr_38547 Neighboring gene STARR-seq mESC enhancer starr_38548 Neighboring gene predicted gene, 41315 Neighboring gene STARR-seq mESC enhancer starr_38549 Neighboring gene STARR-seq mESC enhancer starr_38550 Neighboring gene STARR-seq mESC enhancer starr_38551 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene eukaryotic translation initiation factor 3, subunit E

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within bone mineralization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dopaminergic neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic forelimb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic forelimb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic hindlimb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic hindlimb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in limb development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lung growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of odontogenesis of dentin-containing tooth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within osteoblast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within trachea cartilage morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
R-spondin-2
Names
R-spondin 2 homolog
cristin-2
cysteine-rich and single thrombospondin domain-containing protein 2
mCristin-2
roof plate-specific spondin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357956.1NP_001344885.1  R-spondin-2 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC121609, AC161450
    Consensus CDS
    CCDS27451.1
    UniProtKB/Swiss-Prot
    Q7TPX3, Q8BFU0
    Related
    ENSMUSP00000154600.2, ENSMUST00000226810.2
    Conserved Domains (1) summary
    pfam15913
    Location:40144
    Furin-like_2; Furin-like repeat, cysteine-rich
  2. NM_001357957.1NP_001344886.1  R-spondin-2 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC121609, AC161450
    Conserved Domains (1) summary
    pfam15913
    Location:47151
    Furin-like_2; Furin-like repeat, cysteine-rich
  3. NM_172815.3NP_766403.1  R-spondin-2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_766403.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC121609, AC161450
    Consensus CDS
    CCDS27451.1
    UniProtKB/Swiss-Prot
    Q7TPX3, Q8BFU0
    Related
    ENSMUSP00000067325.7, ENSMUST00000063492.8
    Conserved Domains (1) summary
    pfam15913
    Location:40144
    Furin-like_2; Furin-like repeat, cysteine-rich

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    42884184..43034990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245607.2XP_011243909.1  R-spondin-2 isoform X5

    See identical proteins and their annotated locations for XP_011243909.1

    Conserved Domains (1) summary
    pfam15913
    Location:47151
    Furin-like_2; Furin-like repeat, cysteine-rich
  2. XM_017316596.3XP_017172085.2  R-spondin-2 isoform X4

    Conserved Domains (2) summary
    pfam15913
    Location:40141
    Furin-like_2; Furin-like repeat, cysteine-rich
    pfam19028
    Location:144197
    TSP1_spondin; Spondin-like TSP1 domain
  3. XM_011245609.3XP_011243911.2  R-spondin-2 isoform X2

    Conserved Domains (2) summary
    pfam15913
    Location:47148
    Furin-like_2; Furin-like repeat, cysteine-rich
    pfam19028
    Location:151204
    TSP1_spondin; Spondin-like TSP1 domain
  4. XM_030248538.2XP_030104398.2  R-spondin-2 isoform X4

    Conserved Domains (2) summary
    pfam15913
    Location:40141
    Furin-like_2; Furin-like repeat, cysteine-rich
    pfam19028
    Location:144197
    TSP1_spondin; Spondin-like TSP1 domain
  5. XM_036159394.1XP_036015287.1  R-spondin-2 isoform X3

    Conserved Domains (2) summary
    pfam15913
    Location:40141
    Furin-like_2; Furin-like repeat, cysteine-rich
    pfam19028
    Location:145198
    TSP1_spondin; Spondin-like TSP1 domain
  6. XM_036159393.1XP_036015286.1  R-spondin-2 isoform X1

    Conserved Domains (2) summary
    pfam15913
    Location:47148
    Furin-like_2; Furin-like repeat, cysteine-rich
    pfam19028
    Location:152205
    TSP1_spondin; Spondin-like TSP1 domain