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Card6 caspase recruitment domain family, member 6 [ Mus musculus (house mouse) ]

Gene ID: 239319, updated on 8-Nov-2022

Summary

Official Symbol
Card6provided by MGI
Official Full Name
caspase recruitment domain family, member 6provided by MGI
Primary source
MGI:MGI:3032959
See related
Ensembl:ENSMUSG00000041849 AllianceGenome:MGI:3032959
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D730008L15
Summary
Predicted to act upstream of or within regulation of I-kappaB kinase/NF-kappaB signaling. Predicted to be located in cytoplasm. Is expressed in heart ventricle; lung; upper arm muscle; upper leg muscle; and vertebral axis musculature. Orthologous to human CARD6 (caspase recruitment domain family member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 1.0), testis adult (RPKM 0.6) and 27 other tissues See more
Orthologs
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Genomic context

See Card6 in Genome Data Viewer
Location:
15; 15 A1
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (5126402..5146762, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (5096920..5116562, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene complement component 7 Neighboring gene predicted gene, 25652 Neighboring gene caspase recruitment domain family, member 6 pseudogene Neighboring gene small nucleolar RNA, C/D box 72 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d pseudogene Neighboring gene ribosomal protein L37

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of I-kappaB kinase/NF-kappaB signaling ISA
Inferred from Sequence Alignment
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISA
Inferred from Sequence Alignment
more info
PubMed 

General protein information

Preferred Names
caspase recruitment domain-containing protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163138.1NP_001156610.1  caspase recruitment domain-containing protein 6

    See identical proteins and their annotated locations for NP_001156610.1

    Status: VALIDATED

    Source sequence(s)
    AC131919
    Consensus CDS
    CCDS49573.1
    UniProtKB/TrEMBL
    E9PWH2
    Related
    ENSMUSP00000112833.3, ENSMUST00000118365.3
    Conserved Domains (2) summary
    PHA03247
    Location:7891166
    PHA03247; large tegument protein UL36; Provisional
    pfam00619
    Location:988
    CARD; Caspase recruitment domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    5126402..5146762 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519987.5XP_006520050.2  caspase recruitment domain-containing protein 6 isoform X1

    Conserved Domains (2) summary
    PHA03247
    Location:9391316
    PHA03247; large tegument protein UL36; Provisional
    cd01671
    Location:161229
    CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
  2. XM_030248533.1XP_030104393.1  caspase recruitment domain-containing protein 6 isoform X2

    UniProtKB/TrEMBL
    E9PWH2
    Conserved Domains (2) summary
    PHA03247
    Location:7891166
    PHA03247; large tegument protein UL36; Provisional
    pfam00619
    Location:988
    CARD; Caspase recruitment domain