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Abcc4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 [ Mus musculus (house mouse) ]

Gene ID: 239273, updated on 24-Dec-2019

Summary

Official Symbol
Abcc4provided by MGI
Official Full Name
ATP-binding cassette, sub-family C (CFTR/MRP), member 4provided by MGI
Primary source
MGI:MGI:2443111
See related
Ensembl:ENSMUSG00000032849
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MRP4; MOATB; ABCC4-N1; D630049P08Rik
Expression
Broad expression in kidney adult (RPKM 9.2), bladder adult (RPKM 8.4) and 21 other tissues See more
Orthologs

Genomic context

See Abcc4 in Genome Data Viewer
Location:
14; 14 E4
Exon count:
34
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (118482692..118707856, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (118881914..119105441, complement)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 32093 Neighboring gene RIKEN cDNA 1700044C05 gene Neighboring gene crystallin, zeta pseudogene Neighboring gene U6 spliceosomal RNA Neighboring gene microRNA 6391 Neighboring gene predicted gene, 52104 Neighboring gene predicted gene, 41247 Neighboring gene predicted gene 27198 Neighboring gene predicted gene, 46484

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATPase activity, coupled to transmembrane movement of substances IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
efflux transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
prostaglandin transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
PubMed 
xenobiotic transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cilium assembly ISO
Inferred from Sequence Orthology
more info
PubMed 
drug transmembrane transport TAS
Traceable Author Statement
more info
PubMed 
export across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
prostaglandin secretion ISO
Inferred from Sequence Orthology
more info
PubMed 
transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
NOT cilium IDA
Inferred from Direct Assay
more info
PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
platelet dense granule membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
multidrug resistance-associated protein 4
NP_001028508.2
NP_001157147.1
NP_001157148.1
XP_006519073.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033336.3NP_001028508.2  multidrug resistance-associated protein 4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC154419, AC167668, AK157723, CT025694
    Consensus CDS
    CCDS27335.1
    UniProtKB/TrEMBL
    E9Q236, Q3TZN9
    Related
    ENSMUSP00000042186.6, ENSMUST00000036554.13
    Conserved Domains (5) summary
    cd03244
    Location:10391258
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:410610
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:111269
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    pfam00664
    Location:718991
    ABC_membrane; ABC transporter transmembrane region
    cl00549
    Location:96365
    ABC_membrane; ABC transporter transmembrane region
  2. NM_001163675.1NP_001157147.1  multidrug resistance-associated protein 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC154419, AC167668, AK032802, AK052778, AK157723
    UniProtKB/TrEMBL
    Q3TZN9
    Conserved Domains (5) summary
    cd03244
    Location:9961215
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:367567
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:81226
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    pfam00664
    Location:675948
    ABC_membrane; ABC transporter transmembrane region
    cl00549
    Location:53322
    ABC_membrane; ABC transporter transmembrane region
  3. NM_001163676.1NP_001157148.1  multidrug resistance-associated protein 4 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC154419, AC167668, CT025694
    Consensus CDS
    CCDS49565.1
    UniProtKB/TrEMBL
    E9Q467
    Related
    ENSMUSP00000129677.1, ENSMUST00000166646.1
    Conserved Domains (5) summary
    cd03244
    Location:9641183
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:335535
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:111194
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    pfam00664
    Location:643916
    ABC_membrane; ABC transporter transmembrane region
    cl00549
    Location:104290
    ABC_membrane; ABC transporter transmembrane region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000080.6 Reference GRCm38.p6 C57BL/6J

    Range
    118482692..118707856 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519010.4XP_006519073.1  multidrug resistance-associated protein 4 isoform X1

    Conserved Domains (3) summary
    cd03250
    Location:410610
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    COG1132
    Location:90637
    MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
    cl00549
    Location:96365
    ABC_membrane; ABC transporter transmembrane region

RNA

  1. XR_874344.3 RNA Sequence

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