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Homez homeodomain leucine zipper-encoding gene [ Mus musculus (house mouse) ]

Gene ID: 239099, updated on 4-Dec-2022

Summary

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Official Symbol
Homezprovided by MGI
Official Full Name
homeodomain leucine zipper-encoding geneprovided by MGI
Primary source
MGI:MGI:2678023
See related
Ensembl:ENSMUSG00000057156 AllianceGenome:MGI:2678023
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1443
Summary
Enables DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including enteric nervous system; future brain; genitourinary system; liver; and sensory organ. Orthologous to human HOMEZ (homeobox and leucine zipper encoding). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 6.4), ovary adult (RPKM 1.6) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Homez in Genome Data Viewer
Location:
14; 14 C3
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55090193..55109285, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54852736..54871728, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 Neighboring gene ring finger protein 212B Neighboring gene predicted gene, 17772 Neighboring gene protein phosphatase 1, regulatory subunit 3E Neighboring gene BCL2-like 2 Neighboring gene poly(A) binding protein, nuclear 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Homez, a homeobox leucine zipper gene specific to the vertebrate lineage. Bayarsaihan D, et al. Proc Natl Acad Sci U S A, 2003 Sep 2. PMID 12925734, Free PMC Article
  2. The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation. Carmona-Mora P, et al. Hum Genet, 2015 Oct. PMID 26275350
  3. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
  4. Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Memic F, et al. Gastroenterology, 2018 Feb. PMID 29031500, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295

See all (15) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
homeobox and leucine zipper protein Homez
Names
homeodomain leucine zipper-containing factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177705.1 → NP_001171176.1  homeobox and leucine zipper protein Homez

    See identical proteins and their annotated locations for NP_001171176.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC116591, BC094669, CJ068402
    Consensus CDS
    CCDS27102.1
    UniProtKB/Swiss-Prot
    Q80W88
    UniProtKB/TrEMBL
    A0A0R4J108
    Related
    ENSMUSP00000117828.2, ENSMUST00000142283.4
    Conserved Domains (3) summary
    COG5576
    Location:274 → 417
    COG5576; Homeodomain-containing transcription factor [Transcription]
    cd00086
    Location:328 → 385
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:430 → 476
    Homez; Homeodomain leucine-zipper encoding, Homez

  2. NM_183174.3 → NP_898997.2  homeobox and leucine zipper protein Homez

    See identical proteins and their annotated locations for NP_898997.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC116591, BC094669
    Consensus CDS
    CCDS27102.1
    UniProtKB/Swiss-Prot
    Q80W88
    UniProtKB/TrEMBL
    A0A0R4J108
    Related
    ENSMUSP00000079929.6, ENSMUST00000081162.6
    Conserved Domains (3) summary
    COG5576
    Location:274 → 417
    COG5576; Homeodomain-containing transcription factor [Transcription]
    cd00086
    Location:328 → 385
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:430 → 476
    Homez; Homeodomain leucine-zipper encoding, Homez

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    55090193..55109285 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316014.3 → XP_017171503.1  homeobox and leucine zipper protein Homez isoform X2

    Conserved Domains (3) summary
    COG5576
    Location:313 → 456
    COG5576; Homeodomain-containing transcription factor [Transcription]
    cd00086
    Location:367 → 424
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:469 → 515
    Homez; Homeodomain leucine-zipper encoding, Homez

  2. XM_006518977.5 → XP_006519040.1  homeobox and leucine zipper protein Homez isoform X1

    Conserved Domains (3) summary
    COG5576
    Location:396 → 539
    COG5576; Homeodomain-containing transcription factor [Transcription]
    cd00086
    Location:450 → 507
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:552 → 598
    Homez; Homeodomain leucine-zipper encoding, Homez

  3. XM_006518978.5 → XP_006519041.1  homeobox and leucine zipper protein Homez isoform X3

    Conserved Domains (3) summary
    COG5576
    Location:313 → 456
    COG5576; Homeodomain-containing transcription factor [Transcription]
    cd00086
    Location:367 → 424
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:469 → 515
    Homez; Homeodomain leucine-zipper encoding, Homez
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80W88.2 GenPept UniProtKB/Swiss-Prot:Q80W88

Gene LinkOut

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