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Hs2st1 heparan sulfate 2-O-sulfotransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 23908, updated on 5-Jan-2023

Summary

Official Symbol
Hs2st1provided by MGI
Official Full Name
heparan sulfate 2-O-sulfotransferase 1provided by MGI
Primary source
MGI:MGI:1346049
See related
Ensembl:ENSMUSG00000040151 AllianceGenome:MGI:1346049
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2OST; Hs2st; mKIAA0448
Summary
Enables heparan sulfate 2-O-sulfotransferase activity. Acts upstream of or within several processes, including heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; heparin metabolic process; and ureteric bud formation. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Is expressed in brain and future brain. Orthologous to human HS2ST1 (heparan sulfate 2-O-sulfotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 8.3), whole brain E14.5 (RPKM 6.1) and 28 other tissues See more
Orthologs
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Genomic context

See Hs2st1 in Genome Data Viewer
Location:
3; 3 H2
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (144135462..144275977, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (144429701..144570216, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54186 Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene predicted gene 43560 Neighboring gene predicted gene, 46829 Neighboring gene selenoprotein F Neighboring gene ribosomal protein L9, pseudogene 8

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heparan sulfate 2-O-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables heparan sulfate 2-O-sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables heparan sulfate 2-O-sulfotransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
heparan sulfate 2-O-sulfotransferase 1
Names
2-O-sulfotransferase
NP_001342163.1
NP_035958.3
XP_006501513.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355234.1NP_001342163.1  heparan sulfate 2-O-sulfotransferase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC123880, AC159976, BC059008
    Conserved Domains (1) summary
    pfam03567
    Location:76327
    Sulfotransfer_2; Sulfotransferase family
  2. NM_011828.4NP_035958.3  heparan sulfate 2-O-sulfotransferase 1 isoform 2

    See identical proteins and their annotated locations for NP_035958.3

    Status: VALIDATED

    Source sequence(s)
    AC123880, AC159976, BC059008
    Consensus CDS
    CCDS17883.1
    UniProtKB/Swiss-Prot
    Q8R3H7, Q9JLK2
    Related
    ENSMUSP00000043066.8, ENSMUST00000043325.9
    Conserved Domains (1) summary
    pfam03567
    Location:76326
    Sulfotransfer_2; Sulfotransferase family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    144135462..144275977 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501450.5XP_006501513.1  heparan sulfate 2-O-sulfotransferase 1 isoform X1

    Conserved Domains (1) summary
    pfam03567
    Location:18269
    Sulfotransfer_2; Sulfotransferase family