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Arhgap22 Rho GTPase activating protein 22 [ Mus musculus (house mouse) ]

Gene ID: 239027, updated on 12-May-2024

Summary

Official Symbol
Arhgap22provided by MGI
Official Full Name
Rho GTPase activating protein 22provided by MGI
Primary source
MGI:MGI:2443418
See related
Ensembl:ENSMUSG00000063506 AllianceGenome:MGI:2443418
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RHOGAP2; p68RacGAP; B230341L19Rik
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity and regulation of postsynapse organization. Predicted to act upstream of or within angiogenesis and cell differentiation. Predicted to be located in cytoplasm and nucleus. Predicted to be active in glutamatergic synapse. Orthologous to human ARHGAP22 (Rho GTPase activating protein 22). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 3.9), ovary adult (RPKM 3.8) and 27 other tissues See more
Orthologs
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Genomic context

See Arhgap22 in Genome Data Viewer
Location:
14 B; 14 20.15 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (32935952..33091893)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (33213994..33369936)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36348 Neighboring gene predicted gene, 25498 Neighboring gene predicted pseudogene 6340 Neighboring gene predicted gene, 41130 Neighboring gene STARR-seq mESC enhancer starr_36351 Neighboring gene mitogen-activated protein kinase 8 Neighboring gene STARR-seq mESC enhancer starr_36353 Neighboring gene FERM and PDZ domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC47316

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of postsynapse organization ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
rho GTPase-activating protein 22
Names
rho-type GTPase-activating protein 22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153800.4NP_722495.3  rho GTPase-activating protein 22

    See identical proteins and their annotated locations for NP_722495.3

    Status: VALIDATED

    Source sequence(s)
    AK046097, AK078218, BB370610
    Consensus CDS
    CCDS26926.2
    UniProtKB/Swiss-Prot
    Q6QHH6, Q8BL80, Q8BVH4, Q8CHY5
    Related
    ENSMUSP00000107587.3, ENSMUST00000111956.9
    Conserved Domains (4) summary
    cd04390
    Location:157355
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    pfam07111
    Location:602683
    HCR; Alpha helical coiled-coil rod protein (HCR)
    pfam09726
    Location:493683
    Macoilin; Macoilin family
    cl17171
    Location:42157
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    32935952..33091893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518956.5XP_006519019.1  rho GTPase-activating protein 22 isoform X3

    Conserved Domains (3) summary
    cd04390
    Location:173371
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    TIGR02168
    Location:610698
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl17171
    Location:42157
    PH-like; Pleckstrin homology-like domain
  2. XM_011245053.4XP_011243355.1  rho GTPase-activating protein 22 isoform X5

    See identical proteins and their annotated locations for XP_011243355.1

    UniProtKB/Swiss-Prot
    Q6QHH6, Q8BL80, Q8BVH4, Q8CHY5
    Conserved Domains (4) summary
    cd04390
    Location:157355
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    pfam07111
    Location:602683
    HCR; Alpha helical coiled-coil rod protein (HCR)
    pfam09726
    Location:493683
    Macoilin; Macoilin family
    cl17171
    Location:42157
    PH-like; Pleckstrin homology-like domain
  3. XM_036158588.1XP_036014481.1  rho GTPase-activating protein 22 isoform X3

    Conserved Domains (3) summary
    cd04390
    Location:173371
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    TIGR02168
    Location:610698
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl17171
    Location:42157
    PH-like; Pleckstrin homology-like domain
  4. XM_006518957.5XP_006519020.1  rho GTPase-activating protein 22 isoform X4

    Conserved Domains (4) summary
    cd04390
    Location:167365
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    pfam07111
    Location:612693
    HCR; Alpha helical coiled-coil rod protein (HCR)
    pfam09726
    Location:503693
    Macoilin; Macoilin family
    cl17171
    Location:36151
    PH-like; Pleckstrin homology-like domain
  5. XM_030247787.2XP_030103647.1  rho GTPase-activating protein 22 isoform X6

    Conserved Domains (4) summary
    cd04390
    Location:151349
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    pfam07111
    Location:596677
    HCR; Alpha helical coiled-coil rod protein (HCR)
    pfam09726
    Location:487677
    Macoilin; Macoilin family
    cl17171
    Location:36151
    PH-like; Pleckstrin homology-like domain
  6. XM_006518954.5XP_006519017.1  rho GTPase-activating protein 22 isoform X1

    Conserved Domains (4) summary
    cd04390
    Location:193391
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    pfam07111
    Location:638719
    HCR; Alpha helical coiled-coil rod protein (HCR)
    pfam09726
    Location:529719
    Macoilin; Macoilin family
    cl17171
    Location:62177
    PH-like; Pleckstrin homology-like domain
  7. XM_017316004.3XP_017171493.1  rho GTPase-activating protein 22 isoform X2

    Conserved Domains (4) summary
    cd04390
    Location:177375
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    pfam07111
    Location:622703
    HCR; Alpha helical coiled-coil rod protein (HCR)
    pfam09726
    Location:513703
    Macoilin; Macoilin family
    cl17171
    Location:62177
    PH-like; Pleckstrin homology-like domain
  8. XM_017316006.3XP_017171495.1  rho GTPase-activating protein 22 isoform X7

    Conserved Domains (4) summary
    cd04390
    Location:134332
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    pfam07111
    Location:579660
    HCR; Alpha helical coiled-coil rod protein (HCR)
    pfam09726
    Location:470660
    Macoilin; Macoilin family
    cl17171
    Location:62147
    PH-like; Pleckstrin homology-like domain
  9. XM_006518959.3XP_006519022.1  rho GTPase-activating protein 22 isoform X8

    UniProtKB/TrEMBL
    D3Z1Y5
    Conserved Domains (4) summary
    cd04390
    Location:77275
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    pfam07111
    Location:522603
    HCR; Alpha helical coiled-coil rod protein (HCR)
    pfam09726
    Location:413603
    Macoilin; Macoilin family
    cl17171
    Location:1861
    PH-like; Pleckstrin homology-like domain
  10. XM_006518961.5XP_006519024.1  rho GTPase-activating protein 22 isoform X10

    UniProtKB/TrEMBL
    D3Z1Y5
    Related
    ENSMUSP00000107586.2, ENSMUST00000111955.2
    Conserved Domains (4) summary
    cd04390
    Location:61259
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    pfam07111
    Location:506587
    HCR; Alpha helical coiled-coil rod protein (HCR)
    pfam09726
    Location:397587
    Macoilin; Macoilin family
    cl17171
    Location:1861
    PH-like; Pleckstrin homology-like domain
  11. XM_036158589.1XP_036014482.1  rho GTPase-activating protein 22 isoform X13

    UniProtKB/TrEMBL
    D3Z1Y5
    Conserved Domains (2) summary
    cd04390
    Location:18216
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    TIGR02168
    Location:455543
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  12. XM_006518960.4XP_006519023.1  rho GTPase-activating protein 22 isoform X9

    UniProtKB/TrEMBL
    D3Z1Y5
    Conserved Domains (4) summary
    cd04390
    Location:77275
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    pfam07111
    Location:522603
    HCR; Alpha helical coiled-coil rod protein (HCR)
    pfam09726
    Location:413603
    Macoilin; Macoilin family
    cl17171
    Location:1861
    PH-like; Pleckstrin homology-like domain
  13. XM_006518962.4XP_006519025.1  rho GTPase-activating protein 22 isoform X11

    UniProtKB/TrEMBL
    D3Z1Y5
    Related
    ENSMUST00000137590.8
    Conserved Domains (4) summary
    cd04390
    Location:61259
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    pfam07111
    Location:506587
    HCR; Alpha helical coiled-coil rod protein (HCR)
    pfam09726
    Location:397587
    Macoilin; Macoilin family
    cl17171
    Location:1861
    PH-like; Pleckstrin homology-like domain
  14. XM_006518963.5XP_006519026.1  rho GTPase-activating protein 22 isoform X12

    UniProtKB/TrEMBL
    D3Z1Y5
    Conserved Domains (3) summary
    cd04390
    Location:33231
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    pfam07111
    Location:478559
    HCR; Alpha helical coiled-coil rod protein (HCR)
    pfam09726
    Location:369559
    Macoilin; Macoilin family
  15. XM_011245054.1XP_011243356.1  rho GTPase-activating protein 22 isoform X14

    Conserved Domains (3) summary
    TIGR02168
    Location:286374
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam09726
    Location:185375
    Macoilin; Macoilin family
    cl02570
    Location:147
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

RNA

  1. XR_004938394.1 RNA Sequence

  2. XR_003950847.2 RNA Sequence

  3. XR_004938393.1 RNA Sequence