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Gtf2h2 general transcription factor II H, polypeptide 2 [ Mus musculus (house mouse) ]

Gene ID: 23894, updated on 26-Sep-2022

Summary

Official Symbol
Gtf2h2provided by MGI
Official Full Name
general transcription factor II H, polypeptide 2provided by MGI
Primary source
MGI:MGI:1345669
See related
Ensembl:ENSMUSG00000021639 AllianceGenome:MGI:1345669
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p44; 44kDa; Btf2p44; BTF2 p44; BTF2-p44
Summary
Predicted to enable RNA polymerase II general transcription initiation factor activity and protein N-terminus binding activity. Predicted to be involved in nucleotide-excision repair and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within DNA repair. Predicted to be located in nuclear speck. Predicted to be part of core TFIIH complex portion of holo TFIIH complex and transcription factor TFIID complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; integumental system; and nervous system. Orthologous to several human genes including GTF2H2C (GTF2H2 family member C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 10.7), limb E14.5 (RPKM 9.8) and 28 other tissues See more
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Genomic context

See Gtf2h2 in Genome Data Viewer
Location:
13 D1; 13 53.21 cM
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (100596726..100629123, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (100460218..100492609, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 38 pseudogene Neighboring gene ribosomal protein L31, pseudogene 13 Neighboring gene NLR family, apoptosis inhibitory protein 1 Neighboring gene occludin Neighboring gene small nucleolar RNA SNORA48 Neighboring gene eukaryotic translation initiation factor 4, gamma 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the Gtf2h2 gene: The Gtf2h2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of core TFIIH complex portion of holo TFIIH complex ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription factor TFIID complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription factor TFIIH core complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription factor TFIIH holo complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of transcription factor TFIIH holo complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
general transcription factor IIH subunit 2
Names
TFIIH basal transcription factor complex p44 subunit
basal transcription factor 2, p44 subunit
basic transcription factor 2 44 kDa subunit
general transcription factor II H, polypeptide 2 (44 kDa subunit)
general transcription factor IIH, polypeptide 2 (44 kDa subunit)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360706.1NP_001347635.1  general transcription factor IIH subunit 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC158536
    UniProtKB/TrEMBL
    A0A8C6IBB8
    Conserved Domains (2) summary
    cl06838
    Location:289389
    C1_4; TFIIH C1-like domain
    pfam04056
    Location:64255
    Ssl1; Ssl1-like
  2. NM_022011.4NP_071294.3  general transcription factor IIH subunit 2 isoform 1

    See identical proteins and their annotated locations for NP_071294.3

    Status: VALIDATED

    Source sequence(s)
    BC053382, BY277671, BY480509, DV662169
    Consensus CDS
    CCDS26730.1
    UniProtKB/Swiss-Prot
    Q9JIB4
    UniProtKB/TrEMBL
    Q7TPV0
    Related
    ENSMUSP00000065228.8, ENSMUST00000066984.14
    Conserved Domains (2) summary
    pfam04056
    Location:64255
    Ssl1; Ssl1-like
    cl06838
    Location:289389
    C1_4; TFIIH C1-like domain

RNA

  1. NR_153794.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC158536
    Related
    ENSMUST00000145266.8

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    100596726..100629123 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517662.3XP_006517725.1  general transcription factor IIH subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_006517725.1

    UniProtKB/TrEMBL
    A0A8C6IBB8
    Conserved Domains (2) summary
    cl06838
    Location:289389
    C1_4; TFIIH C1-like domain
    pfam04056
    Location:64255
    Ssl1; Ssl1-like

RNA

  1. XR_873756.4 RNA Sequence

  2. XR_873759.4 RNA Sequence

  3. XR_004938028.1 RNA Sequence

  4. XR_004938029.1 RNA Sequence