U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ppwd1 peptidylprolyl isomerase domain and WD repeat containing 1 [ Mus musculus (house mouse) ]

Gene ID: 238831, updated on 5-Mar-2024

Summary

Official Symbol
Ppwd1provided by MGI
Official Full Name
peptidylprolyl isomerase domain and WD repeat containing 1provided by MGI
Primary source
MGI:MGI:2443069
See related
Ensembl:ENSMUSG00000021713 AllianceGenome:MGI:2443069
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4632422M10Rik; A330090G21Rik
Summary
Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein peptidyl-prolyl isomerization. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nuclear body. Predicted to be part of catalytic step 2 spliceosome. Orthologous to human PPWD1 (peptidylprolyl isomerase domain and WD repeat containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 6.8), liver E14 (RPKM 4.5) and 20 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Ppwd1 in Genome Data Viewer
Location:
13 D1; 13 56.39 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (104340102..104365378, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (104203594..104228844, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex 13 Neighboring gene STARR-positive B cell enhancer ABC_E8896 Neighboring gene STARR-positive B cell enhancer ABC_E385 Neighboring gene STARR-seq mESC enhancer starr_35535 Neighboring gene shieldin complex subunit 3 Neighboring gene tripartite motif-containing 23 Neighboring gene STARR-positive B cell enhancer ABC_E4090 Neighboring gene centromere protein K Neighboring gene STARR-positive B cell enhancer ABC_E9887 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:105076891-105077195 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 6 Neighboring gene STARR-seq mESC enhancer starr_35536 Neighboring gene STARR-seq mESC enhancer starr_35537 Neighboring gene predicted gene 8680

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclosporin A binding ISO
Inferred from Sequence Orthology
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peptidyl-prolyl cis-trans isomerase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in protein peptidyl-prolyl isomerization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein peptidyl-prolyl isomerization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
peptidylprolyl isomerase domain and WD repeat-containing protein 1
NP_766395.2
XP_011242960.1
XP_017171002.1
XP_017171003.1
XP_017171004.1
XP_036013937.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172807.4NP_766395.2  peptidylprolyl isomerase domain and WD repeat-containing protein 1

    See identical proteins and their annotated locations for NP_766395.2

    Status: VALIDATED

    Source sequence(s)
    AC154216, AK028532, AK043316
    Consensus CDS
    CCDS26748.1
    UniProtKB/Swiss-Prot
    Q0VEA0, Q8CEC6
    Related
    ENSMUSP00000022226.5, ENSMUST00000022226.6
    Conserved Domains (4) summary
    COG2319
    Location:89311
    WD40; WD40 repeat [General function prediction only]
    cd01927
    Location:495643
    cyclophilin_WD40; cyclophilin_WD40: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a WD40 domain. This group consists of several hypothetical and putative eukaryotic and bacterial proteins which have a cyclophilin domain and a WD40 domain. ...
    sd00039
    Location:136177
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:89318
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    104340102..104365378 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244658.3XP_011242960.1  peptidylprolyl isomerase domain and WD repeat-containing protein 1 isoform X4

    Conserved Domains (4) summary
    COG2319
    Location:19176
    WD40; WD40 repeat [General function prediction only]
    cd01927
    Location:355503
    cyclophilin_WD40; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a WD40 domain. This group consists of several hypothetical and putative eukaryotic and bacterial proteins which have a cyclophilin domain and a WD40 domain. Function of the ...
    sd00039
    Location:3981
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:125252
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_017315515.3XP_017171004.1  peptidylprolyl isomerase domain and WD repeat-containing protein 1 isoform X3

    Conserved Domains (1) summary
    cd01927
    Location:172320
    cyclophilin_WD40; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a WD40 domain. This group consists of several hypothetical and putative eukaryotic and bacterial proteins which have a cyclophilin domain and a WD40 domain. Function of the ...
  3. XM_017315514.3XP_017171003.1  peptidylprolyl isomerase domain and WD repeat-containing protein 1 isoform X3

    Conserved Domains (1) summary
    cd01927
    Location:172320
    cyclophilin_WD40; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a WD40 domain. This group consists of several hypothetical and putative eukaryotic and bacterial proteins which have a cyclophilin domain and a WD40 domain. Function of the ...
  4. XM_036158044.1XP_036013937.1  peptidylprolyl isomerase domain and WD repeat-containing protein 1 isoform X1

    Conserved Domains (3) summary
    cd01927
    Location:414562
    cyclophilin_WD40; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a WD40 domain. This group consists of several hypothetical and putative eukaryotic and bacterial proteins which have a cyclophilin domain and a WD40 domain. Function of the ...
    sd00039
    Location:5596
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:8237
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. XM_017315513.2XP_017171002.1  peptidylprolyl isomerase domain and WD repeat-containing protein 1 isoform X2

    Conserved Domains (4) summary
    COG2319
    Location:39160
    WD40; WD40 repeat [General function prediction only]
    cd01927
    Location:339487
    cyclophilin_WD40; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a WD40 domain. This group consists of several hypothetical and putative eukaryotic and bacterial proteins which have a cyclophilin domain and a WD40 domain. Function of the ...
    sd00039
    Location:2365
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:109236
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. XR_001780782.3 RNA Sequence

  2. XR_003950450.2 RNA Sequence

  3. XR_873754.3 RNA Sequence