Gadd45g growth arrest and DNA-damage-inducible 45 gamma [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gadd45gprovided by MGI
Official Full Name: growth arrest and DNA-damage-inducible 45 gammaprovided by MGI
Primary source: MGI:MGI:1346325
See related: Ensembl:ENSMUSG00000021453 AllianceGenome:MGI:1346325
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CR6; DDIT2; OIG37
Summary: Enables identical protein binding activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within negative regulation of protein kinase activity; positive regulation of MAPK cascade; and regulation of cell cycle. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human GADD45G (growth arrest and DNA damage inducible gamma). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 76.7), CNS E14 (RPKM 36.6) and 27 other tissues See more
Orthologs: all
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Genomic context

Location:: 13 A5; 13 26.36 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (52000711..52002511)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (51846675..51848475)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gadd45g insufficiency drives the pathogenesis of myeloproliferative neoplasms.
Title: Gadd45g insufficiency drives the pathogenesis of myeloproliferative neoplasms.
Gadd45g, A Novel Antidepressant Target, Mediates Metformin-Induced Neuronal Differentiation of Neural Stem Cells Via DNA Demethylation.
Title: Gadd45g, A Novel Antidepressant Target, Mediates Metformin-Induced Neuronal Differentiation of Neural Stem Cells Via DNA Demethylation.
MicroRNA-128-1-5p attenuates myocardial ischemia/reperfusion injury by suppressing Gadd45g-mediated apoptotic signaling.
Title: MicroRNA-128-1-5p attenuates myocardial ischemia/reperfusion injury by suppressing Gadd45g-mediated apoptotic signaling.
Non-cell Autonomous OTX2 Homeoprotein Regulates Visual Cortex Plasticity Through Gadd45b/g.
Title: Non-cell Autonomous OTX2 Homeoprotein Regulates Visual Cortex Plasticity Through Gadd45b/g.
Mimicking Age-Associated Gadd45gamma Dysregulation Results in Memory Impairments in Young Adult Mice.
Title: Mimicking Age-Associated Gadd45γ Dysregulation Results in Memory Impairments in Young Adult Mice.
during fear learning, Gadd45gamma serves to act as a coordinator of immediate early gene expression and subsequent memory consolidation by directing temporally specific changes in active DNA demethylation at the promoter of plasticity-related immediate early genes
Title: The DNA Repair-Associated Protein Gadd45γ Regulates the Temporal Coding of Immediate Early Gene Expression within the Prelimbic Prefrontal Cortex and Is Required for the Consolidation of Associative Fear Memory.
PAX5 was found to be an epigenetically inactivated tumor suppressor that inhibited non-small-cell lung proliferation and metastasis, through down-regulating the beta-catenin pathway and up-regulating GADD45G expression.
Title: Paired box 5 is a frequently methylated lung cancer tumour suppressor gene interfering β-catenin signalling and GADD45G expression.
accumulation during myocardial infarction promotes the development and persistence of heart failure by inducing cardiomyocyte apoptosis in a p38 MAPK-dependent manner
Title: Gadd45γ regulates cardiomyocyte death and post-myocardial infarction left ventricular remodelling.
Results suggest the possibility that differential Gadd45a, Gadd45b and Gadd45g expression during development affects neurons, contributing cortical evolution and diversity
Title: Comparative analysis of developmentally regulated expressions of Gadd45a, Gadd45b, and Gadd45g in the mouse and marmoset cerebral cortex.
The Gadd45g-d4Venus mice exhibited very similar labeling patterns in the ventricular zone (VZ), in Gadd45g-d4Venus mice cells could be visualized in more basal areas containing fully differentiated neurons.
Title: Neurogenin2-d4Venus and Gadd45g-d4Venus transgenic mice: visualizing mitotic and migratory behaviors of cells committed to the neuronal lineage in the developing mammalian brain.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (3) 1 citation

General gene information

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Markers

Gadd45g (e-PCR), detects polymorphism
- UniSTS:506920

C86281 (e-PCR)
- UniSTS:160301

AI327420 (e-PCR)
- UniSTS:180532

PMC86941P1 (e-PCR)
- UniSTS:273565

UniSTS:237015 (e-PCR)
- UniSTS:237015

NoName (e-PCR)
- UniSTS:546781

Gadd45g (e-PCR), detects polymorphism
- UniSTS:546781

Gadd45g (e-PCR), detects polymorphism
- UniSTS:546782

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within T-helper 1 cell differentiation	TAS Traceable Author Statement more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of p38MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: growth arrest and DNA damage-inducible protein GADD45 gamma

Names: cytokine-responsive protein CR6; growth arrest and DNA-damage-inducible, gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011817.2 → NP_035947.2 growth arrest and DNA damage-inducible protein GADD45 gamma

See identical proteins and their annotated locations for NP_035947.2

Status: VALIDATED

Source sequence(s)

AC126247

Consensus CDS

CCDS26515.1

UniProtKB/TrEMBL

Q99M58, Q9R0S0

Related

ENSMUSP00000021903.3, ENSMUST00000021903.3

Conserved Domains (1) summary

pfam01248
Location:24 → 106

Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family